FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309571915> ?p ?o ?g. }

• W4309571915 endingPage "634" @default.
• W4309571915 startingPage "628" @default.
• W4309571915 abstract "Bisphenol A-glycidyl methacrylate (BisGMA) is a methacrylate monomer that is mainly used in three-dimensional structures to reconstruct dental and bony defects. BisGMA has toxic and proinflammatory effects on macrophages. Rutin is a natural flavonol glycoside that is present in various plants and has useful biological effects, such as anti-inflammatory, anticancer, and antioxidative effects. The aim of this study was to investigate the anti-inflammation of rutin in macrophages after exposure to BisGMA. Pretreatment of the RAW264.7 macrophage with rutin at 0, 10, 30, and 100 μM for 30 min before being incubated with BisGMA at 0 or 3 μM. Proinflammatory cytokines and prostaglandin (PG) E2 were detected by enzyme-linked immunosorbent assay (ELISA). Nitric oxide (NO) was detected by the Griess assay. Expression and phosphorylation of proteins were measured by Western blot assay. Pretreatment with rutin inhibited the BisGMA-induced generation of proinflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and PGE2, in macrophages. Rutin also suppressed the BisGMA-induced secretion of NO and expression of inducible nitric oxide synthase (iNOS) in a concentration-dependent manner. Furthermore, rutin suppressed the mitogen-activated protein kinase (MAPK) phosphorylation in a concentration-dependent manner. Finally, rutin suppressed the BisGMA-induced phosphorylation of nuclear factor (NF)-κB p65 and degradation of inhibitor of κB (IκB). These results indicate that the concentration of rutin has an inhibitory effect on proinflammatory mediator generation, MAPK phosphorylation, NF-κB p65 phosphorylation, and IκB degradation. In conclusion, rutin is a potential anti-inflammatory agent for BisGMA-stimulated macrophages through NF-κB p65 phosphorylation and IκB degradation resulting from MAPK phosphorylation." @default.
• W4309571915 created "2022-11-28" @default.
• W4309571915 creator A5000175806 @default.
• W4309571915 creator A5021900574 @default.
• W4309571915 creator A5033719743 @default.
• W4309571915 creator A5061017676 @default.
• W4309571915 creator A5076586905 @default.
• W4309571915 creator A5081898709 @default.
• W4309571915 date "2022-11-22" @default.
• W4309571915 modified "2023-10-18" @default.
• W4309571915 title "Rutin alleviates bisphenol <scp>A</scp> ‐glycidyl methacrylate‐induced generation of proinflammatory mediators through the <scp>MAPK</scp> and <scp>NF‐κB</scp> pathways in macrophages" @default.
• W4309571915 cites W1593504264 @default.
• W4309571915 cites W1775256576 @default.
• W4309571915 cites W1965522733 @default.
• W4309571915 cites W1978865096 @default.
• W4309571915 cites W1994976609 @default.
• W4309571915 cites W1996682782 @default.
• W4309571915 cites W1999361510 @default.
• W4309571915 cites W2009676666 @default.
• W4309571915 cites W2017653795 @default.
• W4309571915 cites W2045883164 @default.
• W4309571915 cites W2059548406 @default.
• W4309571915 cites W2096827433 @default.
• W4309571915 cites W2109862246 @default.
• W4309571915 cites W2270098854 @default.
• W4309571915 cites W2301038687 @default.
• W4309571915 cites W2342925175 @default.
• W4309571915 cites W2344819396 @default.
• W4309571915 cites W2807906301 @default.
• W4309571915 cites W2904886317 @default.
• W4309571915 cites W2908045338 @default.
• W4309571915 cites W2913460407 @default.
• W4309571915 cites W2914018305 @default.
• W4309571915 cites W2974291499 @default.
• W4309571915 cites W2995735301 @default.
• W4309571915 cites W3010690997 @default.
• W4309571915 cites W3080801322 @default.
• W4309571915 cites W3082430738 @default.
• W4309571915 cites W3096277299 @default.
• W4309571915 cites W3111621473 @default.
• W4309571915 cites W3127280406 @default.
• W4309571915 cites W3142053945 @default.
• W4309571915 cites W3171413354 @default.
• W4309571915 cites W3180817269 @default.
• W4309571915 cites W3186709725 @default.
• W4309571915 cites W3205212316 @default.
• W4309571915 cites W3207007108 @default.
• W4309571915 cites W3208569491 @default.
• W4309571915 cites W4220936623 @default.
• W4309571915 doi "https://doi.org/10.1002/tox.23711" @default.
• W4309571915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36413001" @default.
• W4309571915 hasPublicationYear "2022" @default.
• W4309571915 type Work @default.
• W4309571915 citedByCount "3" @default.
• W4309571915 countsByYear W43095719152023 @default.
• W4309571915 crossrefType "journal-article" @default.
• W4309571915 hasAuthorship W4309571915A5000175806 @default.
• W4309571915 hasAuthorship W4309571915A5021900574 @default.
• W4309571915 hasAuthorship W4309571915A5033719743 @default.
• W4309571915 hasAuthorship W4309571915A5061017676 @default.
• W4309571915 hasAuthorship W4309571915A5076586905 @default.
• W4309571915 hasAuthorship W4309571915A5081898709 @default.
• W4309571915 hasConcept C11960822 @default.
• W4309571915 hasConcept C164027704 @default.
• W4309571915 hasConcept C178790620 @default.
• W4309571915 hasConcept C17991360 @default.
• W4309571915 hasConcept C181199279 @default.
• W4309571915 hasConcept C185592680 @default.
• W4309571915 hasConcept C203014093 @default.
• W4309571915 hasConcept C2775963812 @default.
• W4309571915 hasConcept C2776914184 @default.
• W4309571915 hasConcept C2777622882 @default.
• W4309571915 hasConcept C2778004101 @default.
• W4309571915 hasConcept C519581460 @default.
• W4309571915 hasConcept C55493867 @default.
• W4309571915 hasConcept C57074206 @default.
• W4309571915 hasConcept C86803240 @default.
• W4309571915 hasConcept C98274493 @default.
• W4309571915 hasConceptScore W4309571915C11960822 @default.
• W4309571915 hasConceptScore W4309571915C164027704 @default.
• W4309571915 hasConceptScore W4309571915C178790620 @default.
• W4309571915 hasConceptScore W4309571915C17991360 @default.
• W4309571915 hasConceptScore W4309571915C181199279 @default.
• W4309571915 hasConceptScore W4309571915C185592680 @default.
• W4309571915 hasConceptScore W4309571915C203014093 @default.
• W4309571915 hasConceptScore W4309571915C2775963812 @default.
• W4309571915 hasConceptScore W4309571915C2776914184 @default.
• W4309571915 hasConceptScore W4309571915C2777622882 @default.
• W4309571915 hasConceptScore W4309571915C2778004101 @default.
• W4309571915 hasConceptScore W4309571915C519581460 @default.
• W4309571915 hasConceptScore W4309571915C55493867 @default.
• W4309571915 hasConceptScore W4309571915C57074206 @default.
• W4309571915 hasConceptScore W4309571915C86803240 @default.
• W4309571915 hasConceptScore W4309571915C98274493 @default.
• W4309571915 hasFunder F4320322795 @default.
• W4309571915 hasIssue "3" @default.
• W4309571915 hasLocation W43095719151 @default.
• W4309571915 hasLocation W43095719152 @default.

• next