FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309581292> ?p ?o ?g. }

• W4309581292 endingPage "1748" @default.
• W4309581292 startingPage "1735" @default.
• W4309581292 abstract "Prediction of antimicrobial target-site pharmacokinetics is of relevance to optimize treatment with antimicrobial agents. A physiologically based pharmacokinetic (PBPK) model framework was developed for prediction of pulmonary pharmacokinetics, including key pulmonary infection sites (i.e. the alveolar macrophages and the epithelial lining fluid).The modelling framework incorporated three lung PBPK models: a general passive permeability-limited model, a drug-specific permeability-limited model and a quantitative structure-property relationship (QSPR)-informed perfusion-limited model. We applied the modelling framework to three fluoroquinolone antibiotics. Incorporation of experimental drug-specific permeability data was found essential for accurate prediction.In the absence of drug-specific transport data, our QSPR-based model has generic applicability. Furthermore, we evaluated the impact of drug properties and pathophysiologically related changes on pulmonary pharmacokinetics. Pulmonary pharmacokinetics were highly affected by physiological changes, causing a shift in the main route of diffusion (i.e. paracellular or transcellular). Finally, we show that lysosomal trapping can cause an overestimation of cytosolic concentrations for basic compounds when measuring drug concentrations in cell homogenate.The developed lung PBPK model framework constitutes a promising tool for characterization of pulmonary exposure of systemically administrated antimicrobials." @default.
• W4309581292 created "2022-11-28" @default.
• W4309581292 creator A5008570912 @default.
• W4309581292 creator A5049073682 @default.
• W4309581292 creator A5075078998 @default.
• W4309581292 creator A5075422062 @default.
• W4309581292 creator A5077172862 @default.
• W4309581292 creator A5085233896 @default.
• W4309581292 creator A5086641499 @default.
• W4309581292 creator A5088109370 @default.
• W4309581292 date "2022-11-19" @default.
• W4309581292 modified "2023-10-09" @default.
• W4309581292 title "Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations" @default.
• W4309581292 cites W177236013 @default.
• W4309581292 cites W1900424145 @default.
• W4309581292 cites W1977698867 @default.
• W4309581292 cites W1985640372 @default.
• W4309581292 cites W1986907506 @default.
• W4309581292 cites W1988662140 @default.
• W4309581292 cites W2019988983 @default.
• W4309581292 cites W2033926558 @default.
• W4309581292 cites W2038812224 @default.
• W4309581292 cites W2042315357 @default.
• W4309581292 cites W2044851945 @default.
• W4309581292 cites W2053928920 @default.
• W4309581292 cites W2076461883 @default.
• W4309581292 cites W2082871367 @default.
• W4309581292 cites W2112694597 @default.
• W4309581292 cites W2124508140 @default.
• W4309581292 cites W2138412150 @default.
• W4309581292 cites W2145533061 @default.
• W4309581292 cites W2146984153 @default.
• W4309581292 cites W2152983548 @default.
• W4309581292 cites W2168418918 @default.
• W4309581292 cites W2178047135 @default.
• W4309581292 cites W2187707217 @default.
• W4309581292 cites W2338294989 @default.
• W4309581292 cites W2463831292 @default.
• W4309581292 cites W2566439396 @default.
• W4309581292 cites W2568762686 @default.
• W4309581292 cites W2592130591 @default.
• W4309581292 cites W2607289612 @default.
• W4309581292 cites W2620241325 @default.
• W4309581292 cites W2746579241 @default.
• W4309581292 cites W2752331950 @default.
• W4309581292 cites W2765271262 @default.
• W4309581292 cites W2782872532 @default.
• W4309581292 cites W2804524829 @default.
• W4309581292 cites W3009577418 @default.
• W4309581292 cites W3020839350 @default.
• W4309581292 cites W3023365912 @default.
• W4309581292 cites W3040114045 @default.
• W4309581292 cites W3085337735 @default.
• W4309581292 cites W3092382993 @default.
• W4309581292 cites W3111016761 @default.
• W4309581292 cites W3159527153 @default.
• W4309581292 cites W3171232861 @default.
• W4309581292 cites W3198853312 @default.
• W4309581292 cites W4206363338 @default.
• W4309581292 cites W4230070433 @default.
• W4309581292 doi "https://doi.org/10.1007/s40262-022-01186-3" @default.
• W4309581292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36401151" @default.
• W4309581292 hasPublicationYear "2022" @default.
• W4309581292 type Work @default.
• W4309581292 citedByCount "0" @default.
• W4309581292 crossrefType "journal-article" @default.
• W4309581292 hasAuthorship W4309581292A5008570912 @default.
• W4309581292 hasAuthorship W4309581292A5049073682 @default.
• W4309581292 hasAuthorship W4309581292A5075078998 @default.
• W4309581292 hasAuthorship W4309581292A5075422062 @default.
• W4309581292 hasAuthorship W4309581292A5077172862 @default.
• W4309581292 hasAuthorship W4309581292A5085233896 @default.
• W4309581292 hasAuthorship W4309581292A5086641499 @default.
• W4309581292 hasAuthorship W4309581292A5088109370 @default.
• W4309581292 hasBestOaLocation W43095812921 @default.
• W4309581292 hasConcept C112705442 @default.
• W4309581292 hasConcept C120882062 @default.
• W4309581292 hasConcept C164126121 @default.
• W4309581292 hasConcept C178790620 @default.
• W4309581292 hasConcept C185592680 @default.
• W4309581292 hasConcept C185867374 @default.
• W4309581292 hasConcept C2780035454 @default.
• W4309581292 hasConcept C41625074 @default.
• W4309581292 hasConcept C4937899 @default.
• W4309581292 hasConcept C501593827 @default.
• W4309581292 hasConcept C55493867 @default.
• W4309581292 hasConcept C60903277 @default.
• W4309581292 hasConcept C71240020 @default.
• W4309581292 hasConcept C71924100 @default.
• W4309581292 hasConcept C98274493 @default.
• W4309581292 hasConceptScore W4309581292C112705442 @default.
• W4309581292 hasConceptScore W4309581292C120882062 @default.
• W4309581292 hasConceptScore W4309581292C164126121 @default.
• W4309581292 hasConceptScore W4309581292C178790620 @default.
• W4309581292 hasConceptScore W4309581292C185592680 @default.
• W4309581292 hasConceptScore W4309581292C185867374 @default.
• W4309581292 hasConceptScore W4309581292C2780035454 @default.
• W4309581292 hasConceptScore W4309581292C41625074 @default.

• next