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- W4309587562 abstract "We propose a continuum model for pattern formation, based on the multiphase model framework, to explore in vitro cell patterning within an extracellular matrix. We demonstrate that, within this framework, chemotaxis-driven cell migration can lead to formation of cell clusters and vascular-like structures in 1D and 2D respectively. The influence on pattern formation of additional mechanisms commonly included in multiphase tissue models, including cell-matrix traction, contact inhibition, and cell-cell aggregation, are also investigated. Using sensitivity analysis, the relative impact of each model parameter on the simulation outcomes is assessed to identify the key parameters involved. Chemoattractant-matrix binding is further included, motivated by previous experimental studies, and to augment the spatial scale of patterning to within a biologically plausible range. Key findings from the in-depth parameter analysis of the 1D models, both with and without chemoattractant-matrix binding, are demonstrated to translate well to the 2D model, obtaining vascular-like cell patterning for multiple parameter regimes. Overall, we demonstrate a biologically-motivated multiphase model capable of generating long-term pattern formation on a biologically plausible spatial scale both in 1D and 2D, with applications for modelling in vitro vascular network formation." @default.
- W4309587562 created "2022-11-28" @default.
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- W4309587562 date "2022-11-18" @default.
- W4309587562 modified "2023-09-27" @default.
- W4309587562 title "Formation of vascular-like structures using a chemotaxis-driven multiphase model" @default.
- W4309587562 doi "https://doi.org/10.48550/arxiv.2211.10205" @default.
- W4309587562 hasPublicationYear "2022" @default.
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