Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309587781> ?p ?o ?g. }
- W4309587781 abstract "Abstract In healthy muscle, the rapid release of calcium ions (Ca2+) with excitation–contraction (E-C) coupling, results in elevations in Ca2+ concentrations which can exceed 10-fold that of resting values. The sizable transient changes in Ca2+ concentrations are necessary for the activation of signaling pathways, which rely on Ca2+ as a second messenger, including those involved with force generation, fiber type distribution and hypertrophy. However, prolonged elevations in intracellular Ca2+ can result in the unwanted activation of Ca2+ signaling pathways that cause muscle damage, dysfunction, and disease. Muscle employs several calcium handling and calcium transport proteins that function to rapidly return Ca2+ concentrations back to resting levels following contraction. This review will detail our current understanding of calcium handling during the decay phase of intracellular calcium transients in healthy skeletal and cardiac muscle. We will also discuss how impairments in Ca2+ transport can occur and how mishandling of Ca2+ can lead to the pathogenesis and/or progression of skeletal muscle myopathies and cardiomyopathies." @default.
- W4309587781 created "2022-11-28" @default.
- W4309587781 creator A5036358147 @default.
- W4309587781 creator A5064107837 @default.
- W4309587781 creator A5089244320 @default.
- W4309587781 date "2022-12-01" @default.
- W4309587781 modified "2023-10-18" @default.
- W4309587781 title "Skeletal and cardiac muscle calcium transport regulation in health and disease" @default.
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