FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309600604> ?p ?o ?g. }

• W4309600604 abstract "Abstract Kidney renal clear cell carcinoma (KIRC) is one of the most common malignancies and PANoptosis is a unique inflammatory programmed cell death regulated by the PANoptosome. MicroRNAs (miRNAs) are important regulators of cancer occurrence and progress. However, the potential role of PANoptosis-related miRNAs (PRMs) in KIRC remains elusive. In this study, KIRC samples were collected from The Cancer Genome Atlas database and two Gene Expression Omnibus datasets and PRMs were identified by previous literature reports. Univariate Cox and Lasso Cox regression analyses were applied to identify prognosis PRMs and then construct a PANoptosis-related miRNA prognostic signature evaluated by the risk score. By a variety of R software packages and web analysis tools, we found the high-risk patients bear worse survival prognoses and were significantly associated with high-grade and advanced-stage tumors. Furthermore, we demonstrated the low-risk group had significant changes in metabolic pathways and the high-risk group was characterized by high immune cell infiltration and immune checkpoints expression as well as low IC50 values of chemotherapeutic agents, suggesting that the high-risk patients may benefit more from immunotherapy and chemotherapy. In short, we constructed a PANoptosis-related miRNA signature and revealed its potential significance on the clinicopathological features and tumor immunity, providing new strategies for precise treatment." @default.
• W4309600604 created "2022-11-28" @default.
• W4309600604 creator A5009318195 @default.
• W4309600604 creator A5021769901 @default.
• W4309600604 creator A5051099833 @default.
• W4309600604 creator A5066404216 @default.
• W4309600604 creator A5074622138 @default.
• W4309600604 creator A5077476508 @default.
• W4309600604 creator A5078313825 @default.
• W4309600604 creator A5080268249 @default.
• W4309600604 date "2022-11-22" @default.
• W4309600604 modified "2023-10-12" @default.
• W4309600604 title "A novel defined PANoptosis-related miRNA signature for predicting prognosis and immune characteristics in Kidney Renal Clear Cell Carcinoma" @default.
• W4309600604 cites W1971915082 @default.
• W4309600604 cites W1978008054 @default.
• W4309600604 cites W2066604995 @default.
• W4309600604 cites W2120052164 @default.
• W4309600604 cites W2133811295 @default.
• W4309600604 cites W2157503340 @default.
• W4309600604 cites W2170918307 @default.
• W4309600604 cites W2295202170 @default.
• W4309600604 cites W2338576144 @default.
• W4309600604 cites W2551911481 @default.
• W4309600604 cites W2578528809 @default.
• W4309600604 cites W2588025094 @default.
• W4309600604 cites W2726542547 @default.
• W4309600604 cites W2788640168 @default.
• W4309600604 cites W2805302875 @default.
• W4309600604 cites W2943293743 @default.
• W4309600604 cites W2956024695 @default.
• W4309600604 cites W3000339487 @default.
• W4309600604 cites W3005088442 @default.
• W4309600604 cites W3016145305 @default.
• W4309600604 cites W3046214398 @default.
• W4309600604 cites W3066271196 @default.
• W4309600604 cites W3096272935 @default.
• W4309600604 cites W3097228396 @default.
• W4309600604 cites W3118913605 @default.
• W4309600604 cites W3119005666 @default.
• W4309600604 cites W3121927206 @default.
• W4309600604 cites W3126305922 @default.
• W4309600604 cites W3176529968 @default.
• W4309600604 cites W3193190854 @default.
• W4309600604 cites W3203623718 @default.
• W4309600604 cites W3205475594 @default.
• W4309600604 cites W4282944040 @default.
• W4309600604 doi "https://doi.org/10.21203/rs.3.rs-2164940/v2" @default.
• W4309600604 hasPublicationYear "2022" @default.
• W4309600604 type Work @default.
• W4309600604 citedByCount "0" @default.
• W4309600604 crossrefType "posted-content" @default.
• W4309600604 hasAuthorship W4309600604A5009318195 @default.
• W4309600604 hasAuthorship W4309600604A5021769901 @default.
• W4309600604 hasAuthorship W4309600604A5051099833 @default.
• W4309600604 hasAuthorship W4309600604A5066404216 @default.
• W4309600604 hasAuthorship W4309600604A5074622138 @default.
• W4309600604 hasAuthorship W4309600604A5077476508 @default.
• W4309600604 hasAuthorship W4309600604A5078313825 @default.
• W4309600604 hasAuthorship W4309600604A5080268249 @default.
• W4309600604 hasBestOaLocation W43096006041 @default.
• W4309600604 hasConcept C104317684 @default.
• W4309600604 hasConcept C121608353 @default.
• W4309600604 hasConcept C126322002 @default.
• W4309600604 hasConcept C143998085 @default.
• W4309600604 hasConcept C145059251 @default.
• W4309600604 hasConcept C203014093 @default.
• W4309600604 hasConcept C2777472916 @default.
• W4309600604 hasConcept C2777701055 @default.
• W4309600604 hasConcept C2781068499 @default.
• W4309600604 hasConcept C2781278892 @default.
• W4309600604 hasConcept C50382708 @default.
• W4309600604 hasConcept C54355233 @default.
• W4309600604 hasConcept C60644358 @default.
• W4309600604 hasConcept C70721500 @default.
• W4309600604 hasConcept C71924100 @default.
• W4309600604 hasConcept C86803240 @default.
• W4309600604 hasConcept C8891405 @default.
• W4309600604 hasConceptScore W4309600604C104317684 @default.
• W4309600604 hasConceptScore W4309600604C121608353 @default.
• W4309600604 hasConceptScore W4309600604C126322002 @default.
• W4309600604 hasConceptScore W4309600604C143998085 @default.
• W4309600604 hasConceptScore W4309600604C145059251 @default.
• W4309600604 hasConceptScore W4309600604C203014093 @default.
• W4309600604 hasConceptScore W4309600604C2777472916 @default.
• W4309600604 hasConceptScore W4309600604C2777701055 @default.
• W4309600604 hasConceptScore W4309600604C2781068499 @default.
• W4309600604 hasConceptScore W4309600604C2781278892 @default.
• W4309600604 hasConceptScore W4309600604C50382708 @default.
• W4309600604 hasConceptScore W4309600604C54355233 @default.
• W4309600604 hasConceptScore W4309600604C60644358 @default.
• W4309600604 hasConceptScore W4309600604C70721500 @default.
• W4309600604 hasConceptScore W4309600604C71924100 @default.
• W4309600604 hasConceptScore W4309600604C86803240 @default.
• W4309600604 hasConceptScore W4309600604C8891405 @default.
• W4309600604 hasLocation W43096006041 @default.
• W4309600604 hasOpenAccess W4309600604 @default.
• W4309600604 hasPrimaryLocation W43096006041 @default.
• W4309600604 hasRelatedWork W1509042831 @default.
• W4309600604 hasRelatedWork W1969425504 @default.
• W4309600604 hasRelatedWork W1983427659 @default.

• next