Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309606056> ?p ?o ?g. }
- W4309606056 abstract "Circulating-tumor DNA (ctDNA) has emerged as an important biomarker for monitoring disease status in cancer patients. Different ctDNA testing platforms have shown promising results in the early detection of disease, monitoring response to treatment, and prognostication in metastatic melanoma. However, several challenges exist, including the reduced shedding of ctDNA into the bloodstream in the metastatic setting, differences in sensitivity among various ctDNA assays, and the inherent inability to distinguish tumor-specific mutations from other mutations that are not related to the cancer of interest. Using a ctDNA assay that is designed to detect multiple single-nucleotide variants (SNVs) that are specific to the tumor itself may allow for more accurate monitoring of disease status in metastatic melanoma. In this case series, we describe a real-world experience using a personalized, tumor-informed ctDNA assay to monitor the clinical trajectories of four patients with metastatic melanoma. Our report highlights potential benefits and limitations using ctDNA in this setting to inform clinical decision-making. This report provides a proof of concept of the technique using an mPCR-NGS-based ctDNA assay (Signatera TM) in the clinical context and in adjunct with other radiological information. Large cohort prospective trials would be needed to validate the utility and validity of this approach." @default.
- W4309606056 created "2022-11-28" @default.
- W4309606056 creator A5001703836 @default.
- W4309606056 creator A5054735261 @default.
- W4309606056 creator A5068703491 @default.
- W4309606056 creator A5080536692 @default.
- W4309606056 creator A5089816080 @default.
- W4309606056 creator A5091279323 @default.
- W4309606056 date "2022-11-17" @default.
- W4309606056 modified "2023-10-14" @default.
- W4309606056 title "Case report: Real-world experience using a personalized cancer-specific circulating tumor DNA assay in different metastatic melanoma scenarios" @default.
- W4309606056 cites W2027735722 @default.
- W4309606056 cites W2060573548 @default.
- W4309606056 cites W2167806838 @default.
- W4309606056 cites W2179502834 @default.
- W4309606056 cites W2239118478 @default.
- W4309606056 cites W2258535515 @default.
- W4309606056 cites W2271392525 @default.
- W4309606056 cites W2296405075 @default.
- W4309606056 cites W2402146695 @default.
- W4309606056 cites W2483137767 @default.
- W4309606056 cites W2588078993 @default.
- W4309606056 cites W2608738563 @default.
- W4309606056 cites W2611081422 @default.
- W4309606056 cites W2765099905 @default.
- W4309606056 cites W2766764630 @default.
- W4309606056 cites W2769575972 @default.
- W4309606056 cites W2789072552 @default.
- W4309606056 cites W2790122515 @default.
- W4309606056 cites W2799502477 @default.
- W4309606056 cites W2805768122 @default.
- W4309606056 cites W2813050034 @default.
- W4309606056 cites W2897483101 @default.
- W4309606056 cites W2899311685 @default.
- W4309606056 cites W2921702329 @default.
- W4309606056 cites W2939548416 @default.
- W4309606056 cites W2944044607 @default.
- W4309606056 cites W2944318130 @default.
- W4309606056 cites W2972182678 @default.
- W4309606056 cites W2978554061 @default.
- W4309606056 cites W2982310169 @default.
- W4309606056 cites W3013544035 @default.
- W4309606056 cites W3018718832 @default.
- W4309606056 cites W3029735381 @default.
- W4309606056 cites W3088621202 @default.
- W4309606056 cites W3131642700 @default.
- W4309606056 cites W3181438909 @default.
- W4309606056 cites W3214513174 @default.
- W4309606056 cites W3216951708 @default.
- W4309606056 cites W4210886213 @default.
- W4309606056 cites W745076224 @default.
- W4309606056 doi "https://doi.org/10.3389/fonc.2022.978996" @default.
- W4309606056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36465349" @default.
- W4309606056 hasPublicationYear "2022" @default.
- W4309606056 type Work @default.
- W4309606056 citedByCount "3" @default.
- W4309606056 countsByYear W43096060562023 @default.
- W4309606056 crossrefType "journal-article" @default.
- W4309606056 hasAuthorship W4309606056A5001703836 @default.
- W4309606056 hasAuthorship W4309606056A5054735261 @default.
- W4309606056 hasAuthorship W4309606056A5068703491 @default.
- W4309606056 hasAuthorship W4309606056A5080536692 @default.
- W4309606056 hasAuthorship W4309606056A5089816080 @default.
- W4309606056 hasAuthorship W4309606056A5091279323 @default.
- W4309606056 hasBestOaLocation W43096060561 @default.
- W4309606056 hasConcept C121608353 @default.
- W4309606056 hasConcept C126322002 @default.
- W4309606056 hasConcept C143998085 @default.
- W4309606056 hasConcept C151730666 @default.
- W4309606056 hasConcept C2777658100 @default.
- W4309606056 hasConcept C2779134260 @default.
- W4309606056 hasConcept C2779343474 @default.
- W4309606056 hasConcept C2781197716 @default.
- W4309606056 hasConcept C2781335228 @default.
- W4309606056 hasConcept C2994587330 @default.
- W4309606056 hasConcept C32220436 @default.
- W4309606056 hasConcept C502942594 @default.
- W4309606056 hasConcept C535046627 @default.
- W4309606056 hasConcept C55493867 @default.
- W4309606056 hasConcept C60644358 @default.
- W4309606056 hasConcept C71924100 @default.
- W4309606056 hasConcept C86803240 @default.
- W4309606056 hasConceptScore W4309606056C121608353 @default.
- W4309606056 hasConceptScore W4309606056C126322002 @default.
- W4309606056 hasConceptScore W4309606056C143998085 @default.
- W4309606056 hasConceptScore W4309606056C151730666 @default.
- W4309606056 hasConceptScore W4309606056C2777658100 @default.
- W4309606056 hasConceptScore W4309606056C2779134260 @default.
- W4309606056 hasConceptScore W4309606056C2779343474 @default.
- W4309606056 hasConceptScore W4309606056C2781197716 @default.
- W4309606056 hasConceptScore W4309606056C2781335228 @default.
- W4309606056 hasConceptScore W4309606056C2994587330 @default.
- W4309606056 hasConceptScore W4309606056C32220436 @default.
- W4309606056 hasConceptScore W4309606056C502942594 @default.
- W4309606056 hasConceptScore W4309606056C535046627 @default.
- W4309606056 hasConceptScore W4309606056C55493867 @default.
- W4309606056 hasConceptScore W4309606056C60644358 @default.
- W4309606056 hasConceptScore W4309606056C71924100 @default.
- W4309606056 hasConceptScore W4309606056C86803240 @default.
- W4309606056 hasLocation W43096060561 @default.