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- W4309607314 startingPage "14156" @default.
- W4309607314 abstract "Peroxisome proliferator-activated receptor alpha (PPARα) is expressed throughout the mammalian gut: in epithelial cells, in the villi of enterocytes and in Paneth cells of intestinal crypts, as well as in some immune cells (e.g., lamina propria macrophages, dendritic cells) of the mucosa. This review examines the reciprocal interaction between PPARα activation and intestinal microbiota. We refer to the published data confirming that microbiota products can influence PPARα signaling and, on the other hand, PPARα activation is able to affect microbiota profile, viability, and diversity. PPARα impact on the broad spectrum of events connected to metabolism, signaling (e.g., NO production), immunological tolerance to dietary antigens, immunity and permeability of the gut are also discussed. We believe that the phenomena described here play a prominent role in gut homeostasis. Therefore, in conclusion we propose future directions for research, including the application of synthetic activators and natural endogenous ligands of PPARα (i.e., endocannabinoids) as therapeutics for intestinal pathologies and systemic diseases assumed to be related to gut dysbiosis." @default.
- W4309607314 created "2022-11-28" @default.
- W4309607314 creator A5007156585 @default.
- W4309607314 creator A5044988784 @default.
- W4309607314 creator A5079778918 @default.
- W4309607314 date "2022-11-16" @default.
- W4309607314 modified "2023-09-26" @default.
- W4309607314 title "The PPARα Regulation of the Gut Physiology in Regard to Interaction with Microbiota, Intestinal Immunity, Metabolism, and Permeability" @default.
- W4309607314 cites W1560656231 @default.
- W4309607314 cites W1573681132 @default.
- W4309607314 cites W1595488088 @default.
- W4309607314 cites W1611522350 @default.
- W4309607314 cites W1819429514 @default.
- W4309607314 cites W1821918060 @default.
- W4309607314 cites W1968719918 @default.
- W4309607314 cites W1968917850 @default.
- W4309607314 cites W1971415551 @default.
- W4309607314 cites W1971450364 @default.
- W4309607314 cites W1972101838 @default.
- W4309607314 cites W1979698072 @default.
- W4309607314 cites W1984238073 @default.
- W4309607314 cites W1990731021 @default.
- W4309607314 cites W2005665370 @default.
- W4309607314 cites W2007968040 @default.
- W4309607314 cites W2008454176 @default.
- W4309607314 cites W2008539465 @default.
- W4309607314 cites W2010446492 @default.
- W4309607314 cites W2013142337 @default.
- W4309607314 cites W2015663542 @default.
- W4309607314 cites W2016366885 @default.
- W4309607314 cites W2016792399 @default.
- W4309607314 cites W2018745802 @default.
- W4309607314 cites W2019965911 @default.
- W4309607314 cites W2020929610 @default.
- W4309607314 cites W2021251015 @default.
- W4309607314 cites W2021798000 @default.
- W4309607314 cites W2023670351 @default.
- W4309607314 cites W2027268808 @default.
- W4309607314 cites W2028520715 @default.
- W4309607314 cites W2029204453 @default.
- W4309607314 cites W2041528712 @default.
- W4309607314 cites W2042172193 @default.
- W4309607314 cites W2042676931 @default.
- W4309607314 cites W2043928338 @default.
- W4309607314 cites W2044008757 @default.
- W4309607314 cites W2050609518 @default.
- W4309607314 cites W2052543150 @default.
- W4309607314 cites W2054459606 @default.
- W4309607314 cites W2055291719 @default.
- W4309607314 cites W2058347393 @default.
- W4309607314 cites W2062905130 @default.
- W4309607314 cites W2067834484 @default.
- W4309607314 cites W2068646907 @default.
- W4309607314 cites W2069098110 @default.
- W4309607314 cites W2069388628 @default.
- W4309607314 cites W2073332363 @default.
- W4309607314 cites W2077248729 @default.
- W4309607314 cites W2093632450 @default.
- W4309607314 cites W2097875133 @default.
- W4309607314 cites W2103137874 @default.
- W4309607314 cites W2104890139 @default.
- W4309607314 cites W2107066107 @default.
- W4309607314 cites W2110491379 @default.
- W4309607314 cites W2115153703 @default.
- W4309607314 cites W2115647000 @default.
- W4309607314 cites W2127005978 @default.
- W4309607314 cites W2129155846 @default.
- W4309607314 cites W2130921667 @default.
- W4309607314 cites W2136417551 @default.
- W4309607314 cites W2139334262 @default.
- W4309607314 cites W2142239894 @default.
- W4309607314 cites W2143535440 @default.
- W4309607314 cites W2147790901 @default.
- W4309607314 cites W2151528895 @default.
- W4309607314 cites W2155924614 @default.
- W4309607314 cites W2157010562 @default.
- W4309607314 cites W2159861680 @default.
- W4309607314 cites W2162913302 @default.
- W4309607314 cites W2167062509 @default.
- W4309607314 cites W2171784982 @default.
- W4309607314 cites W2172383460 @default.
- W4309607314 cites W2228952520 @default.
- W4309607314 cites W2267861477 @default.
- W4309607314 cites W2282766185 @default.
- W4309607314 cites W2298285274 @default.
- W4309607314 cites W2316287986 @default.
- W4309607314 cites W2342769209 @default.
- W4309607314 cites W2343917624 @default.
- W4309607314 cites W2344941018 @default.
- W4309607314 cites W2367535883 @default.
- W4309607314 cites W2406729335 @default.
- W4309607314 cites W2413966026 @default.
- W4309607314 cites W2485268076 @default.
- W4309607314 cites W2490132574 @default.
- W4309607314 cites W2559267012 @default.
- W4309607314 cites W2598697801 @default.
- W4309607314 cites W2626087669 @default.
- W4309607314 cites W2736229177 @default.