FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309609568> ?p ?o ?g. }

• W4309609568 abstract "Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disease caused by a multitude of underlying mechanisms, and molecular mechanistic modeling of COPD, especially at a multi-molecular level, is needed to facilitate the development of molecular diagnostic and prognostic tools and efficacious treatments. Objectives: To investigate the miRNA–mRNA–protein dysregulated network to facilitate prediction of biomarkers and disease subnetwork in COPD in women. Measurements and Results: Three omics data blocks (mRNA, miRNA, and protein) collected from BAL cells from female current-smoker COPD patients, smokers with normal lung function, and healthy never-smokers were integrated with miRNA–mRNA–protein regulatory networks to construct a COPD-specific dysregulated network. Furthermore, downstream network topology, literature annotation, and functional enrichment analysis identified both known and novel disease-related biomarkers and pathways. Both abnormal regulations in miRNA-induced mRNA transcription and protein translation repression play roles in COPD. Finally, the let-7-AIFM1-FKBP1A pathway is highlighted in COPD pathology. Conclusion: For the first time, a comprehensive miRNA–mRNA–protein dysregulated network of primary immune cells from the lung related to COPD in females was constructed to elucidate specific biomarkers and disease pathways. The multi-omics network provides a new molecular insight from a multi-molecular aspect and highlights dysregulated interactions. The highlighted let-7-AIFM1-FKBP1A pathway also indicates new hypotheses of COPD pathology." @default.
• W4309609568 created "2022-11-28" @default.
• W4309609568 creator A5015015915 @default.
• W4309609568 creator A5034382624 @default.
• W4309609568 creator A5082477865 @default.
• W4309609568 creator A5084313819 @default.
• W4309609568 date "2022-11-17" @default.
• W4309609568 modified "2023-10-17" @default.
• W4309609568 title "miRNA–mRNA–protein dysregulated network in COPD in women" @default.
• W4309609568 cites W144423133 @default.
• W4309609568 cites W1870141733 @default.
• W4309609568 cites W1925996676 @default.
• W4309609568 cites W1964895626 @default.
• W4309609568 cites W1972785590 @default.
• W4309609568 cites W1979783084 @default.
• W4309609568 cites W1989277387 @default.
• W4309609568 cites W1997861882 @default.
• W4309609568 cites W2010674002 @default.
• W4309609568 cites W2011376139 @default.
• W4309609568 cites W2048296798 @default.
• W4309609568 cites W2053039860 @default.
• W4309609568 cites W2062533676 @default.
• W4309609568 cites W2064876347 @default.
• W4309609568 cites W2094276973 @default.
• W4309609568 cites W2094433222 @default.
• W4309609568 cites W2101411920 @default.
• W4309609568 cites W2103017472 @default.
• W4309609568 cites W2109227959 @default.
• W4309609568 cites W2120372473 @default.
• W4309609568 cites W2130410032 @default.
• W4309609568 cites W2134629862 @default.
• W4309609568 cites W2136646648 @default.
• W4309609568 cites W2145361279 @default.
• W4309609568 cites W2146512944 @default.
• W4309609568 cites W2146858822 @default.
• W4309609568 cites W2158135353 @default.
• W4309609568 cites W2159482845 @default.
• W4309609568 cites W2167493710 @default.
• W4309609568 cites W2293780464 @default.
• W4309609568 cites W2417391013 @default.
• W4309609568 cites W2577490495 @default.
• W4309609568 cites W2607249259 @default.
• W4309609568 cites W2724907815 @default.
• W4309609568 cites W2744684750 @default.
• W4309609568 cites W2775328130 @default.
• W4309609568 cites W2787112610 @default.
• W4309609568 cites W2789904032 @default.
• W4309609568 cites W2790483441 @default.
• W4309609568 cites W2793364429 @default.
• W4309609568 cites W2811212358 @default.
• W4309609568 cites W2886514991 @default.
• W4309609568 cites W2887367079 @default.
• W4309609568 cites W2888746829 @default.
• W4309609568 cites W2898325858 @default.
• W4309609568 cites W2903540056 @default.
• W4309609568 cites W2946173685 @default.
• W4309609568 cites W2983166786 @default.
• W4309609568 cites W2990975805 @default.
• W4309609568 cites W3087444918 @default.
• W4309609568 cites W3102147110 @default.
• W4309609568 cites W3110825127 @default.
• W4309609568 cites W3112462656 @default.
• W4309609568 cites W3119089886 @default.
• W4309609568 cites W3127895258 @default.
• W4309609568 cites W3205203785 @default.
• W4309609568 cites W4200135473 @default.
• W4309609568 cites W4200385511 @default.
• W4309609568 cites W4205247356 @default.
• W4309609568 cites W4231254854 @default.
• W4309609568 cites W4246271082 @default.
• W4309609568 cites W4294216483 @default.
• W4309609568 doi "https://doi.org/10.3389/fgene.2022.1010048" @default.
• W4309609568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36468026" @default.
• W4309609568 hasPublicationYear "2022" @default.
• W4309609568 type Work @default.
• W4309609568 citedByCount "2" @default.
• W4309609568 crossrefType "journal-article" @default.
• W4309609568 hasAuthorship W4309609568A5015015915 @default.
• W4309609568 hasAuthorship W4309609568A5034382624 @default.
• W4309609568 hasAuthorship W4309609568A5082477865 @default.
• W4309609568 hasAuthorship W4309609568A5084313819 @default.
• W4309609568 hasBestOaLocation W43096095681 @default.
• W4309609568 hasConcept C104317684 @default.
• W4309609568 hasConcept C105580179 @default.
• W4309609568 hasConcept C126322002 @default.
• W4309609568 hasConcept C142724271 @default.
• W4309609568 hasConcept C145059251 @default.
• W4309609568 hasConcept C149364088 @default.
• W4309609568 hasConcept C2776780178 @default.
• W4309609568 hasConcept C2779134260 @default.
• W4309609568 hasConcept C54355233 @default.
• W4309609568 hasConcept C60644358 @default.
• W4309609568 hasConcept C70721500 @default.
• W4309609568 hasConcept C71924100 @default.
• W4309609568 hasConcept C86803240 @default.
• W4309609568 hasConceptScore W4309609568C104317684 @default.
• W4309609568 hasConceptScore W4309609568C105580179 @default.
• W4309609568 hasConceptScore W4309609568C126322002 @default.
• W4309609568 hasConceptScore W4309609568C142724271 @default.
• W4309609568 hasConceptScore W4309609568C145059251 @default.

• next