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• W4309609834 abstract "Human Immunodeficiency virus type 1 (HIV-1) relies on host cell metabolism for all aspects of viral replication. Efficient HIV-1 entry, reverse transcription, and integration occurs in activated T cells because HIV-1 proteins co-opt host metabolic pathways to fuel the anabolic requirements of virion production. The HIV-1 viral life cycle is especially dependent on mTOR, which drives signaling and metabolic pathways required for viral entry, replication, and latency. As a central regulator of host cell metabolism, mTOR and its downstream effectors help to regulate the expression of enzymes within the glycolytic and pentose phosphate pathways along with other metabolic pathways regulating amino acid uptake, lipid metabolism, and autophagy. In HIV-1 pathogenesis, mTOR, in addition to HIF-1α and Myc signaling pathways, alter host cell metabolism to create an optimal environment for viral replication. Increased glycolysis and pentose phosphate pathway activity are required in the early stages of the viral life cycle, such as providing sufficient dNTPs for reverse transcription. In later stages, fatty acid synthesis is required for creating cholesterol and membrane lipids required for viral budding. Epigenetics of the provirus fueled by metabolism and mTOR signaling likewise controls active and latent infection. Acetyl-CoA and methyl group abundance, supplied by the TCA cycle and amino acid uptake respectively, may regulate latent infection and reactivation. Thus, understanding and exploring new connections between cellular metabolism and HIV-1 pathogenesis may yield new insights into the latent viral reservoirs and fuel novel treatments and cure strategies." @default.
• W4309609834 created "2022-11-28" @default.
• W4309609834 creator A5061892862 @default.
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• W4309609834 date "2022-11-17" @default.
• W4309609834 modified "2023-10-05" @default.
• W4309609834 title "HIV-1 replication and latency are balanced by mTOR-driven cell metabolism" @default.
• W4309609834 cites W1503667331 @default.
• W4309609834 cites W1568529372 @default.
• W4309609834 cites W1624461902 @default.
• W4309609834 cites W1823429634 @default.
• W4309609834 cites W1980926787 @default.
• W4309609834 cites W1982219839 @default.
• W4309609834 cites W1992007798 @default.
• W4309609834 cites W1992962914 @default.
• W4309609834 cites W1995466259 @default.
• W4309609834 cites W2002226709 @default.
• W4309609834 cites W2002583208 @default.
• W4309609834 cites W2008239768 @default.
• W4309609834 cites W2013203169 @default.
• W4309609834 cites W2017335731 @default.
• W4309609834 cites W2021882008 @default.
• W4309609834 cites W2031778182 @default.
• W4309609834 cites W2031959283 @default.
• W4309609834 cites W2033803279 @default.
• W4309609834 cites W2061005894 @default.
• W4309609834 cites W2067164933 @default.
• W4309609834 cites W2067874044 @default.
• W4309609834 cites W2075162479 @default.
• W4309609834 cites W2075394689 @default.
• W4309609834 cites W2078673393 @default.
• W4309609834 cites W2079999658 @default.
• W4309609834 cites W2082895492 @default.
• W4309609834 cites W2083097178 @default.
• W4309609834 cites W2088607080 @default.
• W4309609834 cites W2093528359 @default.
• W4309609834 cites W2097200312 @default.
• W4309609834 cites W2105697998 @default.
• W4309609834 cites W2111724662 @default.
• W4309609834 cites W2117225238 @default.
• W4309609834 cites W2123778842 @default.
• W4309609834 cites W2135096349 @default.
• W4309609834 cites W2139987952 @default.
• W4309609834 cites W2142759365 @default.
• W4309609834 cites W2166978542 @default.
• W4309609834 cites W2181681557 @default.
• W4309609834 cites W2256397044 @default.
• W4309609834 cites W2341924879 @default.
• W4309609834 cites W2519255293 @default.
• W4309609834 cites W2529395414 @default.
• W4309609834 cites W2559233139 @default.
• W4309609834 cites W2564084609 @default.
• W4309609834 cites W2605743056 @default.
• W4309609834 cites W2735881021 @default.
• W4309609834 cites W2740538710 @default.
• W4309609834 cites W2761410950 @default.
• W4309609834 cites W2770715322 @default.
• W4309609834 cites W2781948754 @default.
• W4309609834 cites W2783692413 @default.
• W4309609834 cites W2800519954 @default.
• W4309609834 cites W2892020069 @default.
• W4309609834 cites W2906650498 @default.
• W4309609834 cites W2907310704 @default.
• W4309609834 cites W2916670168 @default.
• W4309609834 cites W2923624122 @default.
• W4309609834 cites W2951091314 @default.
• W4309609834 cites W2959448571 @default.
• W4309609834 cites W2990974738 @default.
• W4309609834 cites W2991727328 @default.
• W4309609834 cites W3011006802 @default.
• W4309609834 cites W3011976283 @default.
• W4309609834 cites W3012963517 @default.
• W4309609834 cites W3036964244 @default.
• W4309609834 cites W3042392407 @default.
• W4309609834 cites W3047004407 @default.
• W4309609834 cites W3048895235 @default.
• W4309609834 cites W3092257892 @default.
• W4309609834 cites W3128207667 @default.
• W4309609834 cites W3134857370 @default.
• W4309609834 cites W3138260440 @default.
• W4309609834 cites W3139303129 @default.
• W4309609834 cites W3144076125 @default.
• W4309609834 cites W3183194982 @default.
• W4309609834 cites W3200553918 @default.
• W4309609834 cites W4205625853 @default.
• W4309609834 cites W4220915852 @default.
• W4309609834 cites W4224936011 @default.
• W4309609834 doi "https://doi.org/10.3389/fcimb.2022.1068436" @default.
• W4309609834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36467738" @default.
• W4309609834 hasPublicationYear "2022" @default.
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