Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309613376> ?p ?o ?g. }
- W4309613376 endingPage "14164" @default.
- W4309613376 startingPage "14164" @default.
- W4309613376 abstract "Glioblastoma is refractory to therapy and presents a significant oncological challenge. Promising immunotherapies have not shown the promise observed in other aggressive cancers. The reasons for this include the highly immuno-suppressive tumour microenvironment controlled by the glioblastoma cells and heterogeneous phenotype of the glioblastoma cells. Here, we wanted to better understand which glioblastoma phenotypes produced the regulatory cytokines, particularly those that are implicated in shaping the immune microenvironment. In this study, we employed nanoString analysis of the glioblastoma transcriptome, and proteomic analysis (proteome profiler arrays and cytokine profiling) of secreted cytokines by different glioblastoma phenotypes. These phenotypes were cultured to reflect a spectrum of glioblastoma cells present in tumours, by culturing an enhanced stem-like phenotype of glioblastoma cells or a more differentiated phenotype following culture with serum. Extensive secretome profiling reveals that there is considerable heterogeneity in secretion patterns between serum-derived and glioblastoma stem-like cells, as well as between individuals. Generally, however, the serum-derived phenotypes appear to be the primary producers of cytokines associated with immune cell recruitment into the tumour microenvironment. Therefore, these glioblastoma cells have considerable importance in shaping the immune landscape in glioblastoma and represent a valuable therapeutic target that should not be ignored." @default.
- W4309613376 created "2022-11-28" @default.
- W4309613376 creator A5010102166 @default.
- W4309613376 creator A5021856789 @default.
- W4309613376 creator A5031189811 @default.
- W4309613376 creator A5039857861 @default.
- W4309613376 creator A5043535405 @default.
- W4309613376 creator A5088686006 @default.
- W4309613376 date "2022-11-16" @default.
- W4309613376 modified "2023-10-17" @default.
- W4309613376 title "Comprehensive Assessment of Secreted Immuno-Modulatory Cytokines by Serum-Differentiated and Stem-like Glioblastoma Cells Reveals Distinct Differences between Glioblastoma Phenotypes" @default.
- W4309613376 cites W1481702625 @default.
- W4309613376 cites W1530763983 @default.
- W4309613376 cites W16521146 @default.
- W4309613376 cites W1680083592 @default.
- W4309613376 cites W1864919249 @default.
- W4309613376 cites W1876708341 @default.
- W4309613376 cites W1895277992 @default.
- W4309613376 cites W1898569975 @default.
- W4309613376 cites W1966107523 @default.
- W4309613376 cites W1985987855 @default.
- W4309613376 cites W1990788258 @default.
- W4309613376 cites W1991845503 @default.
- W4309613376 cites W1994447535 @default.
- W4309613376 cites W1996314416 @default.
- W4309613376 cites W1997294930 @default.
- W4309613376 cites W2003609395 @default.
- W4309613376 cites W2029174607 @default.
- W4309613376 cites W2035404015 @default.
- W4309613376 cites W2039144163 @default.
- W4309613376 cites W2045186570 @default.
- W4309613376 cites W2050007032 @default.
- W4309613376 cites W2051250007 @default.
- W4309613376 cites W2060420860 @default.
- W4309613376 cites W2061159965 @default.
- W4309613376 cites W2062783581 @default.
- W4309613376 cites W2073586533 @default.
- W4309613376 cites W2103944130 @default.
- W4309613376 cites W2114843025 @default.
- W4309613376 cites W2131286018 @default.
- W4309613376 cites W2149441684 @default.
- W4309613376 cites W2169435545 @default.
- W4309613376 cites W2175751692 @default.
- W4309613376 cites W2211731027 @default.
- W4309613376 cites W2280099094 @default.
- W4309613376 cites W2298626553 @default.
- W4309613376 cites W2399245969 @default.
- W4309613376 cites W2465309696 @default.
- W4309613376 cites W2507880739 @default.
- W4309613376 cites W2520597008 @default.
- W4309613376 cites W2531373072 @default.
- W4309613376 cites W2560005855 @default.
- W4309613376 cites W2581747126 @default.
- W4309613376 cites W2592014993 @default.
- W4309613376 cites W2614537806 @default.
- W4309613376 cites W2765224588 @default.
- W4309613376 cites W2774484554 @default.
- W4309613376 cites W2776709082 @default.
- W4309613376 cites W2784093632 @default.
- W4309613376 cites W2791477629 @default.
- W4309613376 cites W2794708707 @default.
- W4309613376 cites W2795561878 @default.
- W4309613376 cites W2799441834 @default.
- W4309613376 cites W2801248003 @default.
- W4309613376 cites W2888470526 @default.
- W4309613376 cites W2894477715 @default.
- W4309613376 cites W2896149243 @default.
- W4309613376 cites W2900046418 @default.
- W4309613376 cites W2914673480 @default.
- W4309613376 cites W2919041616 @default.
- W4309613376 cites W2923548794 @default.
- W4309613376 cites W2936375023 @default.
- W4309613376 cites W2990269792 @default.
- W4309613376 cites W2994409610 @default.
- W4309613376 cites W3005258006 @default.
- W4309613376 cites W3007182235 @default.
- W4309613376 cites W3014876791 @default.
- W4309613376 cites W3022149235 @default.
- W4309613376 cites W3027286012 @default.
- W4309613376 cites W3036384505 @default.
- W4309613376 cites W3081073774 @default.
- W4309613376 cites W3087691354 @default.
- W4309613376 cites W3093221119 @default.
- W4309613376 cites W3105672863 @default.
- W4309613376 cites W3107446921 @default.
- W4309613376 cites W3111826740 @default.
- W4309613376 cites W3122049048 @default.
- W4309613376 cites W3132155386 @default.
- W4309613376 doi "https://doi.org/10.3390/ijms232214164" @default.
- W4309613376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36430641" @default.
- W4309613376 hasPublicationYear "2022" @default.
- W4309613376 type Work @default.
- W4309613376 citedByCount "0" @default.
- W4309613376 crossrefType "journal-article" @default.
- W4309613376 hasAuthorship W4309613376A5010102166 @default.
- W4309613376 hasAuthorship W4309613376A5021856789 @default.
- W4309613376 hasAuthorship W4309613376A5031189811 @default.
- W4309613376 hasAuthorship W4309613376A5039857861 @default.