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• W4309620761 abstract "Abstract SARS-CoV-2 can infect human cells through the recognition of the human angiotensin-converting enzyme 2 (ACE2) receptors. This affinity is given by six amino acid located in the receptor binding domain (RBD) region within the Spike protein. Genetic recombination involving bat and pangolin Sarbecoviruses , and natural selection have been proposed as possible explanations for the acquisition of these amino acids. In this study we employed Bayesian phylogenetics to jointly reconstruct the phylogeny of the RBD among human, bat and pangolin Sarbecoviruses and detect recombination events affecting this region of the genome. A recombination event involving RaTG13, the closest relative of SARS-CoV-2 that lacks five of the six residues, and an unsampled Sarbecovirus lineage was detected. This result suggests that the key amino acids were likely present in the common ancestor of SARS-CoV-2 and RaTG13, with the latter losing five of the amino acids as the result of recombination." @default.
• W4309620761 created "2022-11-28" @default.
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• W4309620761 date "2022-11-22" @default.
• W4309620761 modified "2023-09-26" @default.
• W4309620761 title "Recombination-aware phylogenetic analysis sheds light on the evolutionary origin of SARS-CoV-2" @default.
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• W4309620761 doi "https://doi.org/10.21203/rs.3.rs-2189993/v1" @default.
• W4309620761 hasPublicationYear "2022" @default.
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