Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309621726> ?p ?o ?g. }
- W4309621726 abstract "The fungal cell wall is the initial barrier for the fungi against diverse external stresses, such as osmolarity changes, harmful drugs, and mechanical injuries. This study explores the roles of osmoregulation and the cell wall integrity (CWI) pathway in response to high hydrostatic pressure in the yeast Saccharomyces cerevisiae. We demonstrate the roles of the transmembrane mechanosensor Wsc1 and aquaglyceroporin Fps1 in a general mechanism to maintain cell growth under high-pressure regimes. The promotion of water influx into cells at 25 MPa, as evident by an increase in cell volume and a loss of the plasma membrane eisosome structure, promotes the activation of Wsc1, an activator of the CWI pathway. The downstream mitogen-activated protein kinase Slt2 was hyperphosphorylated at 25 MPa. Glycerol efflux increases via Fps1 phosphorylation, which is initiated by downstream components of the CWI pathway and contributes to the reduction in intracellular osmolarity under high pressure. The elucidation of the mechanisms underlying adaption to high pressure through the well-established CWI pathway could potentially translate to mammalian cells and provide novel insights into cellular mechanosensation." @default.
- W4309621726 created "2022-11-28" @default.
- W4309621726 creator A5021375901 @default.
- W4309621726 creator A5025763912 @default.
- W4309621726 creator A5035487851 @default.
- W4309621726 creator A5037067385 @default.
- W4309621726 creator A5040039190 @default.
- W4309621726 creator A5040292882 @default.
- W4309621726 creator A5048504646 @default.
- W4309621726 creator A5048509472 @default.
- W4309621726 creator A5065435169 @default.
- W4309621726 creator A5076243885 @default.
- W4309621726 creator A5088622044 @default.
- W4309621726 creator A5089133659 @default.
- W4309621726 date "2022-11-17" @default.
- W4309621726 modified "2023-09-27" @default.
- W4309621726 title "The CWI pathway is activated through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae" @default.
- W4309621726 cites W1504082382 @default.
- W4309621726 cites W1522874816 @default.
- W4309621726 cites W1572472250 @default.
- W4309621726 cites W1623463470 @default.
- W4309621726 cites W1911402980 @default.
- W4309621726 cites W1921722373 @default.
- W4309621726 cites W1946074731 @default.
- W4309621726 cites W1966768888 @default.
- W4309621726 cites W1967390330 @default.
- W4309621726 cites W1970247880 @default.
- W4309621726 cites W1978888709 @default.
- W4309621726 cites W1978945721 @default.
- W4309621726 cites W1991352534 @default.
- W4309621726 cites W2007653122 @default.
- W4309621726 cites W2008062150 @default.
- W4309621726 cites W2015644221 @default.
- W4309621726 cites W2019805225 @default.
- W4309621726 cites W2025785314 @default.
- W4309621726 cites W2026154475 @default.
- W4309621726 cites W2031475382 @default.
- W4309621726 cites W2032482025 @default.
- W4309621726 cites W2032977708 @default.
- W4309621726 cites W2036297475 @default.
- W4309621726 cites W2037766522 @default.
- W4309621726 cites W2038352464 @default.
- W4309621726 cites W2040838736 @default.
- W4309621726 cites W2041572922 @default.
- W4309621726 cites W2042623726 @default.
- W4309621726 cites W2046172331 @default.
- W4309621726 cites W2048500913 @default.
- W4309621726 cites W2051598609 @default.
- W4309621726 cites W2052288194 @default.
- W4309621726 cites W2056747087 @default.
- W4309621726 cites W2057857646 @default.
- W4309621726 cites W2068617170 @default.
- W4309621726 cites W2069706217 @default.
- W4309621726 cites W2071468845 @default.
- W4309621726 cites W2073573051 @default.
- W4309621726 cites W2074165115 @default.
- W4309621726 cites W2074743540 @default.
- W4309621726 cites W2088908073 @default.
- W4309621726 cites W2090306001 @default.
- W4309621726 cites W2093885105 @default.
- W4309621726 cites W2100572021 @default.
- W4309621726 cites W2106406948 @default.
- W4309621726 cites W2109497034 @default.
- W4309621726 cites W2110862328 @default.
- W4309621726 cites W2113541813 @default.
- W4309621726 cites W2113674051 @default.
- W4309621726 cites W2114410111 @default.
- W4309621726 cites W2123256370 @default.
- W4309621726 cites W2125049470 @default.
- W4309621726 cites W2125781144 @default.
- W4309621726 cites W2128753174 @default.
- W4309621726 cites W2129725997 @default.
- W4309621726 cites W2129999012 @default.
- W4309621726 cites W2132448980 @default.
- W4309621726 cites W2137031771 @default.
- W4309621726 cites W2140948740 @default.
- W4309621726 cites W2142161768 @default.
- W4309621726 cites W2146503498 @default.
- W4309621726 cites W2148361044 @default.
- W4309621726 cites W2149747871 @default.
- W4309621726 cites W2150856219 @default.
- W4309621726 cites W2151665495 @default.
- W4309621726 cites W2152482111 @default.
- W4309621726 cites W2154835210 @default.
- W4309621726 cites W2156041732 @default.
- W4309621726 cites W2157937554 @default.
- W4309621726 cites W2158944498 @default.
- W4309621726 cites W2159100436 @default.
- W4309621726 cites W2161923873 @default.
- W4309621726 cites W2167347342 @default.
- W4309621726 cites W2170780149 @default.
- W4309621726 cites W2172227367 @default.
- W4309621726 cites W2172266573 @default.
- W4309621726 cites W2242048740 @default.
- W4309621726 cites W2417182268 @default.
- W4309621726 cites W2475287802 @default.
- W4309621726 cites W2525169609 @default.
- W4309621726 cites W2598347507 @default.
- W4309621726 cites W2606980407 @default.
- W4309621726 cites W2738479860 @default.