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• W4309646574 abstract "Crohn's disease (CD) is an idiopathic inflammatory condition of the gastrointestinal tract with the primary method of diagnosis and follow-up being colonoscopy. A disturbed host-microbiome interaction, including the presence of pathobionts, is implicated in initiation and perpetuation of inflammation. As such, we hypothesized that bacterial quorum-sensing (QS) molecules (QSMs), small molecules bacteria generate to regulate gene expression, would be elevated in patients with CD. We collected serum at the time of colonoscopy from patients with CD and healthy controls, determining through biosensors for QSMs that patients with CD had significantly elevated levels of QSMs in serum. Expansion of these studies may allow for QSM levels in serum to serve as a biomarker for intestinal inflammation in patients with CD." @default.
• W4309646574 created "2022-11-29" @default.
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• W4309646574 date "2022-11-22" @default.
• W4309646574 modified "2023-09-25" @default.
• W4309646574 title "Bacterial Quorum-Sensing Molecules in Serum: A Potential Tool for Crohn's Disease Management" @default.
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• W4309646574 doi "https://doi.org/10.14309/ctg.0000000000000547" @default.
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