Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309653595> ?p ?o ?g. }
- W4309653595 abstract "Biomolecular condensates are compartmentalized communities of biomolecules, which unlike traditional organelles, are not enclosed by membranes. Condensates play roles in diverse cellular processes, are dysfunctional in many disease states, and are often enriched in classically “undruggable” targets. In this review, we provide an overview for how drugs can modulate condensate structure and function by phenotypically classifying them as dissolvers (dissolve condensates), inducers (induce condensates), localizers (alter localization of the specific condensate community members) or morphers (alter the physiochemical properties). We discuss the growing list of bioactive molecules that function as condensate modifiers (c-mods), including small molecules, oligonucleotides, and peptides. We propose that understanding mechanisms of condensate perturbation of known c-mods will accelerate the discovery of a new class of therapies for difficult-to-treat diseases." @default.
- W4309653595 created "2022-11-29" @default.
- W4309653595 creator A5003635180 @default.
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- W4309653595 date "2022-11-22" @default.
- W4309653595 modified "2023-10-14" @default.
- W4309653595 title "Principles and functions of condensate modifying drugs" @default.
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- W4309653595 doi "https://doi.org/10.3389/fmolb.2022.1007744" @default.
- W4309653595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36483537" @default.
- W4309653595 hasPublicationYear "2022" @default.
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