FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309656490> ?p ?o ?g. }

• W4309656490 endingPage "39" @default.
• W4309656490 startingPage "32" @default.
• W4309656490 abstract "Antidepressant properties of melatonin and atorvastatin have been reported by clinical and experimental studies. Since both melatonin and atorvastatin possess antioxidant properties and considering the involvement of oxidative stress factors in depression, the aim of the present investigation was to study the possible role of oxidative stress factors in the antidepressant- like effect of melatonin and atorvastatin combination in mice forced swimming test.Following the induction of restraint stress, mice were randomly divided into eight groups including the non-stressed and stressed vehicle-treated groups, melatonin- and atorvastatintreated groups, a combination of melatonin and atorvastatin-treated group, and fluoxetineadministrated group. The open field test (OFT) and forced swimming test (FST) were carried out, and the hippocampus and prefrontal cortex were removed for the measurement of oxidative stress factors.Induction of restraint stress increased the immobility time in FST, and melatonin (10 mg/kg) significantly reduced it. Atorvastatin at both doses of 1 and 10 mg/kg could not alter the immobility time, significantly. Co-administration of melatonin and atorvastatin (10 mg/kg) exerted a significant antidepressant-like response and decreased the immobility time compared with melatonin or atorvastatin (10 mg/kg), alone. Induction of restraint stress elevated the malondialdehyde (MDA) levels in mice's hippocampus, while pretreatment of animals with atorvastatin (10 mg/kg) could reverse it. The co-administration of melatonin and atorvastatin (10 mg/kg) increased the cortical superoxide dismutase (SOD) activity compared with atorvastatin alone, but could not alter the catalase (CAT) activity.It is concluded that atorvastatin might augment the antidepressant-like properties of melatonin in FST." @default.
• W4309656490 created "2022-11-29" @default.
• W4309656490 creator A5014295822 @default.
• W4309656490 creator A5016985741 @default.
• W4309656490 creator A5054125131 @default.
• W4309656490 creator A5059877694 @default.
• W4309656490 creator A5073873190 @default.
• W4309656490 creator A5080007878 @default.
• W4309656490 date "2023-04-01" @default.
• W4309656490 modified "2023-09-23" @default.
• W4309656490 title "Antidepressant-like Properties of Melatonin and Atorvastatin Combination following the Restraint Stress in Mice: A Study of Oxidative Stress Factors" @default.
• W4309656490 cites W1531362368 @default.
• W4309656490 cites W1920770718 @default.
• W4309656490 cites W1956023723 @default.
• W4309656490 cites W1979420282 @default.
• W4309656490 cites W2011564583 @default.
• W4309656490 cites W2016292245 @default.
• W4309656490 cites W2044709062 @default.
• W4309656490 cites W2063799404 @default.
• W4309656490 cites W2064004368 @default.
• W4309656490 cites W2070411016 @default.
• W4309656490 cites W2073289400 @default.
• W4309656490 cites W2074602237 @default.
• W4309656490 cites W2082245790 @default.
• W4309656490 cites W2105160377 @default.
• W4309656490 cites W2107278158 @default.
• W4309656490 cites W2290977912 @default.
• W4309656490 cites W2342237972 @default.
• W4309656490 cites W2344294868 @default.
• W4309656490 cites W2430978158 @default.
• W4309656490 cites W2468086208 @default.
• W4309656490 cites W2485400532 @default.
• W4309656490 cites W2510495333 @default.
• W4309656490 cites W2520833064 @default.
• W4309656490 cites W2529409407 @default.
• W4309656490 cites W2537179835 @default.
• W4309656490 cites W2766059362 @default.
• W4309656490 cites W2771779479 @default.
• W4309656490 cites W2808555573 @default.
• W4309656490 cites W2890762615 @default.
• W4309656490 cites W2901740709 @default.
• W4309656490 cites W2913001463 @default.
• W4309656490 cites W2915510829 @default.
• W4309656490 cites W2924621954 @default.
• W4309656490 cites W2954936922 @default.
• W4309656490 cites W2970381305 @default.
• W4309656490 cites W2988542011 @default.
• W4309656490 cites W2992859425 @default.
• W4309656490 cites W2994246648 @default.
• W4309656490 cites W3037006406 @default.
• W4309656490 cites W3120208697 @default.
• W4309656490 cites W3132077375 @default.
• W4309656490 cites W3135193588 @default.
• W4309656490 cites W3164101471 @default.
• W4309656490 cites W3174932541 @default.
• W4309656490 cites W3174980559 @default.
• W4309656490 cites W4210761033 @default.
• W4309656490 cites W811442419 @default.
• W4309656490 doi "https://doi.org/10.2174/1871524923666221121111501" @default.
• W4309656490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36411564" @default.
• W4309656490 hasPublicationYear "2023" @default.
• W4309656490 type Work @default.
• W4309656490 citedByCount "0" @default.
• W4309656490 crossrefType "journal-article" @default.
• W4309656490 hasAuthorship W4309656490A5014295822 @default.
• W4309656490 hasAuthorship W4309656490A5016985741 @default.
• W4309656490 hasAuthorship W4309656490A5054125131 @default.
• W4309656490 hasAuthorship W4309656490A5059877694 @default.
• W4309656490 hasAuthorship W4309656490A5073873190 @default.
• W4309656490 hasAuthorship W4309656490A5080007878 @default.
• W4309656490 hasConcept C126322002 @default.
• W4309656490 hasConcept C134018914 @default.
• W4309656490 hasConcept C136569192 @default.
• W4309656490 hasConcept C185592680 @default.
• W4309656490 hasConcept C2775838275 @default.
• W4309656490 hasConcept C2776151105 @default.
• W4309656490 hasConcept C2777482532 @default.
• W4309656490 hasConcept C2778182776 @default.
• W4309656490 hasConcept C2778401633 @default.
• W4309656490 hasConcept C2778979269 @default.
• W4309656490 hasConcept C2779177272 @default.
• W4309656490 hasConcept C2781161787 @default.
• W4309656490 hasConcept C71924100 @default.
• W4309656490 hasConcept C98274493 @default.
• W4309656490 hasConceptScore W4309656490C126322002 @default.
• W4309656490 hasConceptScore W4309656490C134018914 @default.
• W4309656490 hasConceptScore W4309656490C136569192 @default.
• W4309656490 hasConceptScore W4309656490C185592680 @default.
• W4309656490 hasConceptScore W4309656490C2775838275 @default.
• W4309656490 hasConceptScore W4309656490C2776151105 @default.
• W4309656490 hasConceptScore W4309656490C2777482532 @default.
• W4309656490 hasConceptScore W4309656490C2778182776 @default.
• W4309656490 hasConceptScore W4309656490C2778401633 @default.
• W4309656490 hasConceptScore W4309656490C2778979269 @default.
• W4309656490 hasConceptScore W4309656490C2779177272 @default.
• W4309656490 hasConceptScore W4309656490C2781161787 @default.
• W4309656490 hasConceptScore W4309656490C71924100 @default.
• W4309656490 hasConceptScore W4309656490C98274493 @default.

• next