Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309657968> ?p ?o ?g. }
- W4309657968 abstract "Abstract Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-cells themselves. Restoration of regulated insulin production is a predominant goal of translational diabetes research. Here, we provide a brief overview of recent advances in the fields of β-cell proliferation, regeneration, and replacement. The discovery of therapeutic targets and associated small molecules has been enabled by improved understanding of β-cell development and cell cycle regulation, as well as advanced high-throughput screening methodologies. Important findings in β-cell transdifferentiation, neogenesis, and stem cell differentiation have nucleated multiple promising therapeutic strategies. In particular, clinical trials are underway using in vitro–generated β-like cells from human pluripotent stem cells. Significant challenges remain for each of these strategies, but continued support for efforts in these research areas will be critical for the generation of distinct diabetes therapies." @default.
- W4309657968 created "2022-11-29" @default.
- W4309657968 creator A5004184923 @default.
- W4309657968 creator A5018767671 @default.
- W4309657968 creator A5035037342 @default.
- W4309657968 date "2022-11-14" @default.
- W4309657968 modified "2023-09-26" @default.
- W4309657968 title "Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement" @default.
- W4309657968 cites W1493922188 @default.
- W4309657968 cites W1502350494 @default.
- W4309657968 cites W1526229661 @default.
- W4309657968 cites W1598254642 @default.
- W4309657968 cites W1655026638 @default.
- W4309657968 cites W1697523131 @default.
- W4309657968 cites W1721336579 @default.
- W4309657968 cites W1828613304 @default.
- W4309657968 cites W1838707203 @default.
- W4309657968 cites W1966143184 @default.
- W4309657968 cites W1971926341 @default.
- W4309657968 cites W1973453325 @default.
- W4309657968 cites W1975817243 @default.
- W4309657968 cites W1980585800 @default.
- W4309657968 cites W1982391086 @default.
- W4309657968 cites W1982756407 @default.
- W4309657968 cites W1983596329 @default.
- W4309657968 cites W1985508368 @default.
- W4309657968 cites W1987959164 @default.
- W4309657968 cites W1991201281 @default.
- W4309657968 cites W1997106678 @default.
- W4309657968 cites W1999123584 @default.
- W4309657968 cites W1999726467 @default.
- W4309657968 cites W2003454094 @default.
- W4309657968 cites W2006919788 @default.
- W4309657968 cites W2010561590 @default.
- W4309657968 cites W2011450045 @default.
- W4309657968 cites W2022106893 @default.
- W4309657968 cites W2032033851 @default.
- W4309657968 cites W2032472678 @default.
- W4309657968 cites W2034264501 @default.
- W4309657968 cites W2035280048 @default.
- W4309657968 cites W2037486173 @default.
- W4309657968 cites W2038404321 @default.
- W4309657968 cites W2040207288 @default.
- W4309657968 cites W2040692229 @default.
- W4309657968 cites W2043204562 @default.
- W4309657968 cites W2049148428 @default.
- W4309657968 cites W2049846760 @default.
- W4309657968 cites W2051567027 @default.
- W4309657968 cites W2052721366 @default.
- W4309657968 cites W2054050767 @default.
- W4309657968 cites W2054361177 @default.
- W4309657968 cites W2055843287 @default.
- W4309657968 cites W2059729638 @default.
- W4309657968 cites W2060351580 @default.
- W4309657968 cites W2060591168 @default.
- W4309657968 cites W2061380383 @default.
- W4309657968 cites W2063535842 @default.
- W4309657968 cites W2063944873 @default.
- W4309657968 cites W2064663954 @default.
- W4309657968 cites W2065459869 @default.
- W4309657968 cites W2069065093 @default.
- W4309657968 cites W2074463323 @default.
- W4309657968 cites W2079088793 @default.
- W4309657968 cites W2080580057 @default.
- W4309657968 cites W2081490620 @default.
- W4309657968 cites W2083457624 @default.
- W4309657968 cites W2084089742 @default.
- W4309657968 cites W2086057553 @default.
- W4309657968 cites W2086943348 @default.
- W4309657968 cites W2089919712 @default.
- W4309657968 cites W2090827556 @default.
- W4309657968 cites W2092489985 @default.
- W4309657968 cites W2095577197 @default.
- W4309657968 cites W2098954537 @default.
- W4309657968 cites W2101526674 @default.
- W4309657968 cites W2102670449 @default.
- W4309657968 cites W2103391067 @default.
- W4309657968 cites W2103986580 @default.
- W4309657968 cites W2106593894 @default.
- W4309657968 cites W2106709311 @default.
- W4309657968 cites W2107471483 @default.
- W4309657968 cites W2107818841 @default.
- W4309657968 cites W2110760195 @default.
- W4309657968 cites W2113278846 @default.
- W4309657968 cites W2113544353 @default.
- W4309657968 cites W2114058685 @default.
- W4309657968 cites W2114552310 @default.
- W4309657968 cites W2115383202 @default.
- W4309657968 cites W2118688616 @default.
- W4309657968 cites W2121147154 @default.
- W4309657968 cites W2121274450 @default.
- W4309657968 cites W2125987139 @default.
- W4309657968 cites W2126780067 @default.
- W4309657968 cites W2128711027 @default.
- W4309657968 cites W2131863955 @default.
- W4309657968 cites W2131932336 @default.
- W4309657968 cites W2131933743 @default.
- W4309657968 cites W2133222023 @default.
- W4309657968 cites W2133741976 @default.
- W4309657968 cites W2134703404 @default.