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• W4309658112 endingPage "e31791" @default.
• W4309658112 startingPage "e31791" @default.
• W4309658112 abstract "Restless legs syndrome (RLS) is a neurological motor disorder with a high prevalence. The treatment efficacy of RLS is unsatisfactory. Radix Paeoniae Alba (RPA) can effectively treat RLS symptoms such as the discomfort of the legs. RPA has great potential for the development of new medications for RLS. Hence, we explored the mechanism of RPA in the treatment of RLS using network pharmacology and molecular docking. The active components and targets of RPA were obtained from the Traditional Chinese Medicine System Pharmacology database and analysis platform and PharmMapper platform. The RLS-related targets were found in GeneCards, OMIM, DrugBank, and DisGeNET databases. The overlapping targets of RPA and RLS were then collected. The active components-overlapping targets network was built, and network topology analysis was performed. Furthermore, Cytoscape 3.9.1 software was used to screen the key components of RPA in the treatment of RLS. Protein-protein interaction was performed using the Search Tool for the Retrieval of Interacting Genes. The gene ontology functions and Kyoto Encyclopedia of Genes and Genomes signaling pathways were analyzed using ClusterProfiler, PathView, and other R packages to reveal the main mechanism of RPA in treating RLS. Component and protein structures were downloaded from the Traditional Chinese Medicine System Pharmacology and Protein Data Bank databases, respectively. The AutoDock 4.2.6 software was used for molecular docking. A total of 12 active components and 109 targets of RPA, as well as 2387 RLS-related targets, were collected. Following that, 47 overlapping targets were obtained. Furthermore, 5 key components and 12 core targets were screened. The results of gene ontology functions were as follows: 2368 biological processes, 264 molecular functions, and 164 cellular components. A total of 207 Kyoto Encyclopedia of Genes and Genomes signaling pathways were obtained, including the lipid and atherosclerosis pathway, the endocrine resistance pathway, the prolactin signaling pathway, and the IL-17 signaling pathway. The components and the core targets completed molecular docking stably. RPA has multi-component, multi-target, and multi-pathway characteristics in treating RLS, which could provide a basis for future research and improve clinical efficacy." @default.
• W4309658112 created "2022-11-29" @default.
• W4309658112 creator A5027835055 @default.
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• W4309658112 date "2022-11-18" @default.
• W4309658112 modified "2023-10-01" @default.
• W4309658112 title "Uncovering the mechanism of Radix Paeoniae Alba in the treatment of restless legs syndrome based on network pharmacology and molecular docking" @default.
• W4309658112 cites W112900471 @default.
• W4309658112 cites W1538332611 @default.
• W4309658112 cites W1581528307 @default.
• W4309658112 cites W1587104475 @default.
• W4309658112 cites W1966468003 @default.
• W4309658112 cites W1967214848 @default.
• W4309658112 cites W1975620728 @default.
• W4309658112 cites W1981352341 @default.
• W4309658112 cites W1987176816 @default.
• W4309658112 cites W1990497776 @default.
• W4309658112 cites W1991393893 @default.
• W4309658112 cites W1995695334 @default.
• W4309658112 cites W1998798504 @default.
• W4309658112 cites W2001560701 @default.
• W4309658112 cites W2004527670 @default.
• W4309658112 cites W2007114641 @default.
• W4309658112 cites W2019653334 @default.
• W4309658112 cites W2022377540 @default.
• W4309658112 cites W2027299312 @default.
• W4309658112 cites W2028145119 @default.
• W4309658112 cites W2033602484 @default.
• W4309658112 cites W2034004540 @default.
• W4309658112 cites W2036820118 @default.
• W4309658112 cites W2042199990 @default.
• W4309658112 cites W2043448072 @default.
• W4309658112 cites W2051061512 @default.
• W4309658112 cites W2053368222 @default.
• W4309658112 cites W2056378510 @default.
• W4309658112 cites W2057995083 @default.
• W4309658112 cites W2060153187 @default.
• W4309658112 cites W2062784137 @default.
• W4309658112 cites W2070265035 @default.
• W4309658112 cites W2083376136 @default.
• W4309658112 cites W2118728043 @default.
• W4309658112 cites W2123128199 @default.
• W4309658112 cites W2124679671 @default.
• W4309658112 cites W2124932341 @default.
• W4309658112 cites W2125015567 @default.
• W4309658112 cites W2136679351 @default.
• W4309658112 cites W2141224543 @default.
• W4309658112 cites W2144033595 @default.
• W4309658112 cites W2146736665 @default.
• W4309658112 cites W2147694941 @default.
• W4309658112 cites W2162151166 @default.
• W4309658112 cites W2183562867 @default.
• W4309658112 cites W2375765155 @default.
• W4309658112 cites W2474747771 @default.
• W4309658112 cites W2577580516 @default.
• W4309658112 cites W2583201344 @default.
• W4309658112 cites W2589691481 @default.
• W4309658112 cites W2611425558 @default.
• W4309658112 cites W2742965033 @default.
• W4309658112 cites W2767891136 @default.
• W4309658112 cites W2770403954 @default.
• W4309658112 cites W2899070097 @default.
• W4309658112 cites W2946412700 @default.
• W4309658112 cites W2965405792 @default.
• W4309658112 cites W2965734876 @default.
• W4309658112 cites W2968300883 @default.
• W4309658112 cites W2969695455 @default.
• W4309658112 cites W2995560263 @default.
• W4309658112 cites W2998733518 @default.
• W4309658112 cites W3015329862 @default.
• W4309658112 cites W3097522053 @default.
• W4309658112 cites W3104537585 @default.
• W4309658112 cites W3107527779 @default.
• W4309658112 cites W3114303272 @default.
• W4309658112 cites W3116657439 @default.
• W4309658112 cites W3154756336 @default.
• W4309658112 cites W3162538759 @default.
• W4309658112 cites W3187020603 @default.
• W4309658112 cites W4200101355 @default.
• W4309658112 cites W4225935536 @default.
• W4309658112 cites W4233120011 @default.
• W4309658112 cites W4280637160 @default.
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• W4309658112 doi "https://doi.org/10.1097/md.0000000000031791" @default.
• W4309658112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36401463" @default.
• W4309658112 hasPublicationYear "2022" @default.
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