Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309658577> ?p ?o ?g. }
- W4309658577 abstract "In different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks lymphatic circulation, the drainage and cleaning function is performed by the glymphatic system, called so for its dependence on glial cells and its similar function to that of the lymphatic system. In the present article, we define glymphatic insufficiency as the inability of the glymphatic system to properly perform the brain cleaning function. Furthermore, we propose that corpora amylacea or wasteosomes, which are protective structures that act as waste containers and accumulate waste products, are, in fact, a manifestation of chronic glymphatic insufficiency. Assuming this premise, we provide an explanation that coherently links the formation, distribution, structure, and function of these bodies in the human brain. Moreover, we open up new perspectives in the study of the glymphatic system since wasteosomes can provide information about which variables have the greatest impact on the glymphatic system and which diseases occur with chronic glymphatic insufficiency. For example, based on the presence of wasteosomes, it seems that aging, sleep disorders, and cerebrovascular pathologies have the highest impact on the glymphatic system, whereas neurodegenerative diseases have a more limited impact. Furthermore, as glymphatic insufficiency is a risk factor for neurodegenerative diseases, information provided by wasteosomes could help to define the strategies and actions that can prevent glymphatic disruptions, thus limiting the risk of developing neurodegenerative diseases." @default.
- W4309658577 created "2022-11-29" @default.
- W4309658577 creator A5004049437 @default.
- W4309658577 creator A5005549219 @default.
- W4309658577 creator A5006814614 @default.
- W4309658577 creator A5044956154 @default.
- W4309658577 creator A5045328350 @default.
- W4309658577 date "2022-11-21" @default.
- W4309658577 modified "2023-10-12" @default.
- W4309658577 title "Wasteosomes ( <i>corpora amylacea</i> ) as a hallmark of chronic glymphatic insufficiency" @default.
- W4309658577 cites W1480060118 @default.
- W4309658577 cites W1525770627 @default.
- W4309658577 cites W1584056801 @default.
- W4309658577 cites W1602860458 @default.
- W4309658577 cites W1965968238 @default.
- W4309658577 cites W1967397867 @default.
- W4309658577 cites W1971176454 @default.
- W4309658577 cites W1971431899 @default.
- W4309658577 cites W1974966760 @default.
- W4309658577 cites W1976048862 @default.
- W4309658577 cites W1976449735 @default.
- W4309658577 cites W1976965104 @default.
- W4309658577 cites W1978579966 @default.
- W4309658577 cites W1980991301 @default.
- W4309658577 cites W1984307826 @default.
- W4309658577 cites W1985790212 @default.
- W4309658577 cites W1986179029 @default.
- W4309658577 cites W1986229796 @default.
- W4309658577 cites W1987158399 @default.
- W4309658577 cites W1992014046 @default.
- W4309658577 cites W1995807446 @default.
- W4309658577 cites W2000482773 @default.
- W4309658577 cites W2000647838 @default.
- W4309658577 cites W2006045265 @default.
- W4309658577 cites W2006156063 @default.
- W4309658577 cites W2009308901 @default.
- W4309658577 cites W2012196633 @default.
- W4309658577 cites W2015092131 @default.
- W4309658577 cites W2016631802 @default.
- W4309658577 cites W2016731602 @default.
- W4309658577 cites W2021493191 @default.
- W4309658577 cites W2023272535 @default.
- W4309658577 cites W2024169050 @default.
- W4309658577 cites W2024955728 @default.
- W4309658577 cites W2027789182 @default.
- W4309658577 cites W2027825307 @default.
- W4309658577 cites W2028498586 @default.
- W4309658577 cites W2028623620 @default.
- W4309658577 cites W2029427618 @default.
- W4309658577 cites W2030757203 @default.
- W4309658577 cites W2030820643 @default.
- W4309658577 cites W2031212282 @default.
- W4309658577 cites W2031540193 @default.
- W4309658577 cites W2033882290 @default.
- W4309658577 cites W2034401693 @default.
- W4309658577 cites W2035415084 @default.
- W4309658577 cites W2042683896 @default.
- W4309658577 cites W2045345982 @default.
- W4309658577 cites W2047315806 @default.
- W4309658577 cites W2051154050 @default.
- W4309658577 cites W2054887329 @default.
- W4309658577 cites W2057990380 @default.
- W4309658577 cites W2061008485 @default.
- W4309658577 cites W2063593314 @default.
- W4309658577 cites W2066623204 @default.
- W4309658577 cites W2070734902 @default.
- W4309658577 cites W2074906210 @default.
- W4309658577 cites W2080890849 @default.
- W4309658577 cites W2081668607 @default.
- W4309658577 cites W2083548652 @default.
- W4309658577 cites W2085203441 @default.
- W4309658577 cites W2085425672 @default.
- W4309658577 cites W2085496213 @default.
- W4309658577 cites W2100314515 @default.
- W4309658577 cites W2100416353 @default.
- W4309658577 cites W2104135033 @default.
- W4309658577 cites W2109120242 @default.
- W4309658577 cites W2110601384 @default.
- W4309658577 cites W2113123671 @default.
- W4309658577 cites W2115632183 @default.
- W4309658577 cites W211905087 @default.
- W4309658577 cites W2125236750 @default.
- W4309658577 cites W2126722763 @default.
- W4309658577 cites W2127147815 @default.
- W4309658577 cites W2127700718 @default.
- W4309658577 cites W2131872983 @default.
- W4309658577 cites W2137181909 @default.
- W4309658577 cites W2144469764 @default.
- W4309658577 cites W2147540668 @default.
- W4309658577 cites W2153524819 @default.
- W4309658577 cites W2155626577 @default.
- W4309658577 cites W2157796001 @default.
- W4309658577 cites W2163225965 @default.
- W4309658577 cites W2163562064 @default.
- W4309658577 cites W2164924935 @default.
- W4309658577 cites W2167127477 @default.
- W4309658577 cites W2167183660 @default.
- W4309658577 cites W2170435537 @default.
- W4309658577 cites W2175580779 @default.
- W4309658577 cites W2296427521 @default.