Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309658840> ?p ?o ?g. }
- W4309658840 endingPage "62" @default.
- W4309658840 startingPage "51" @default.
- W4309658840 abstract "Compared to subcutaneous injections, oral administration of insulin would be a preferred route of drug administration for diabetic patients. For oral delivery, both liposomes and alginate hydrogels face many challenges, including early burst release of the encapsulated drug and poor intestinal drug absorption. Also, adhesion to the intestinal mucosa remains weak, which all result in a low bioavailability of the payload. This study reports on an alginate hydrogel loaded with liposomes for oral insulin administration. Liposomes (Lip) loaded with arginine-insulin complexes (AINS) were incorporated into a hydrogel prepared from cysteine modified alginate (Cys-Alg) to form liposome-in-alginate hydrogels (AINS-Lip-Gel). An ex vivo study proves that intestinal permeation of AINS and AINS-Lip is approximately 2.0 and 6.0-fold, respectively, higher than that of free insulin. The hydrogel retarded early release of insulin (∼30%) from the liposomes and enhanced the intestinal mucosal retention. In vivo experiments revealed that the AINS-Lip-Gel released insulin in a controlled manner and possessed strong hypoglycemic effects. We conclude that liposome-in-alginate hydrogels loaded with AINS represent an attractive strategy for the oral delivery of insulin." @default.
- W4309658840 created "2022-11-29" @default.
- W4309658840 creator A5032211872 @default.
- W4309658840 creator A5045940535 @default.
- W4309658840 creator A5047103780 @default.
- W4309658840 creator A5082892848 @default.
- W4309658840 creator A5084293545 @default.
- W4309658840 date "2023-01-01" @default.
- W4309658840 modified "2023-10-17" @default.
- W4309658840 title "Insulin-loaded liposomes packaged in alginate hydrogels promote the oral bioavailability of insulin" @default.
- W4309658840 cites W1504114827 @default.
- W4309658840 cites W1963853765 @default.
- W4309658840 cites W1982459820 @default.
- W4309658840 cites W1984839032 @default.
- W4309658840 cites W1990832891 @default.
- W4309658840 cites W1996498300 @default.
- W4309658840 cites W2015071666 @default.
- W4309658840 cites W2020678484 @default.
- W4309658840 cites W2021307619 @default.
- W4309658840 cites W2022905205 @default.
- W4309658840 cites W2027344717 @default.
- W4309658840 cites W2052563319 @default.
- W4309658840 cites W2055955443 @default.
- W4309658840 cites W2059453747 @default.
- W4309658840 cites W2061471987 @default.
- W4309658840 cites W2063115767 @default.
- W4309658840 cites W2073217307 @default.
- W4309658840 cites W2075872138 @default.
- W4309658840 cites W2090888546 @default.
- W4309658840 cites W2091742793 @default.
- W4309658840 cites W2094278454 @default.
- W4309658840 cites W2116265317 @default.
- W4309658840 cites W2118978641 @default.
- W4309658840 cites W2130371762 @default.
- W4309658840 cites W2148665822 @default.
- W4309658840 cites W2169448926 @default.
- W4309658840 cites W2314987493 @default.
- W4309658840 cites W2347002449 @default.
- W4309658840 cites W2463538241 @default.
- W4309658840 cites W2572613335 @default.
- W4309658840 cites W2589570306 @default.
- W4309658840 cites W2599276599 @default.
- W4309658840 cites W2760821910 @default.
- W4309658840 cites W2810098751 @default.
- W4309658840 cites W2891457650 @default.
- W4309658840 cites W2897095887 @default.
- W4309658840 cites W2940852958 @default.
- W4309658840 cites W2989121776 @default.
- W4309658840 cites W2990286351 @default.
- W4309658840 cites W2994218670 @default.
- W4309658840 cites W3000520379 @default.
- W4309658840 cites W3006560769 @default.
- W4309658840 cites W3082424886 @default.
- W4309658840 cites W3092580975 @default.
- W4309658840 cites W3103861847 @default.
- W4309658840 cites W3135523241 @default.
- W4309658840 cites W3136858840 @default.
- W4309658840 cites W3197120099 @default.
- W4309658840 cites W3197671491 @default.
- W4309658840 cites W3211513612 @default.
- W4309658840 cites W4200304640 @default.
- W4309658840 cites W4213134076 @default.
- W4309658840 cites W4284964894 @default.
- W4309658840 cites W958869794 @default.
- W4309658840 doi "https://doi.org/10.1016/j.jconrel.2022.11.032" @default.
- W4309658840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36410613" @default.
- W4309658840 hasPublicationYear "2023" @default.
- W4309658840 type Work @default.
- W4309658840 citedByCount "13" @default.
- W4309658840 countsByYear W43096588402023 @default.
- W4309658840 crossrefType "journal-article" @default.
- W4309658840 hasAuthorship W4309658840A5032211872 @default.
- W4309658840 hasAuthorship W4309658840A5045940535 @default.
- W4309658840 hasAuthorship W4309658840A5047103780 @default.
- W4309658840 hasAuthorship W4309658840A5082892848 @default.
- W4309658840 hasAuthorship W4309658840A5084293545 @default.
- W4309658840 hasConcept C108586683 @default.
- W4309658840 hasConcept C126322002 @default.
- W4309658840 hasConcept C13245373 @default.
- W4309658840 hasConcept C150903083 @default.
- W4309658840 hasConcept C163588942 @default.
- W4309658840 hasConcept C178790620 @default.
- W4309658840 hasConcept C181389837 @default.
- W4309658840 hasConcept C185154212 @default.
- W4309658840 hasConcept C185592680 @default.
- W4309658840 hasConcept C202751555 @default.
- W4309658840 hasConcept C207001950 @default.
- W4309658840 hasConcept C26291073 @default.
- W4309658840 hasConcept C2777056448 @default.
- W4309658840 hasConcept C2779306644 @default.
- W4309658840 hasConcept C2779820397 @default.
- W4309658840 hasConcept C2780035454 @default.
- W4309658840 hasConcept C55493867 @default.
- W4309658840 hasConcept C71924100 @default.
- W4309658840 hasConcept C77281830 @default.
- W4309658840 hasConcept C86803240 @default.
- W4309658840 hasConcept C98274493 @default.
- W4309658840 hasConceptScore W4309658840C108586683 @default.