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- W4309659052 startingPage "101805" @default.
- W4309659052 abstract "Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity and outcome. In recent years, several lines of evidence have suggested that individuals with MDD have an elevated risk of age-related adverse outcomes across the lifespan. This review provided evidence of a significant overlap between the biological abnormalities in MDD and biological changes commonly observed during the aging process (i.e., hallmarks of biological aging). Based on such evidence, we formulate a mechanistic model showing how abnormalities in the hallmarks of biological aging can be a common denominator and mediate the elevated risk of age-related health outcomes commonly observed in MDD. Finally, we proposed a roadmap for novel studies to investigate the intersection between the biology of aging and MDD, including the use of geroscience-guided interventions, such as senolytics, to delay or improve major depression by targeting biological aging." @default.
- W4309659052 created "2022-11-29" @default.
- W4309659052 creator A5000839362 @default.
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- W4309659052 creator A5027515586 @default.
- W4309659052 creator A5086396866 @default.
- W4309659052 date "2023-01-01" @default.
- W4309659052 modified "2023-10-16" @default.
- W4309659052 title "Major depression and the biological hallmarks of aging" @default.
- W4309659052 cites W1524549603 @default.
- W4309659052 cites W1627352250 @default.
- W4309659052 cites W1857587085 @default.
- W4309659052 cites W1894734502 @default.
- W4309659052 cites W1918135542 @default.
- W4309659052 cites W1922605075 @default.
- W4309659052 cites W1957468587 @default.
- W4309659052 cites W1970924670 @default.
- W4309659052 cites W1973683611 @default.
- W4309659052 cites W1980825524 @default.
- W4309659052 cites W1984615306 @default.
- W4309659052 cites W1985745132 @default.
- W4309659052 cites W1992949421 @default.
- W4309659052 cites W1996952541 @default.
- W4309659052 cites W1998417918 @default.
- W4309659052 cites W2001686534 @default.
- W4309659052 cites W2004724834 @default.
- W4309659052 cites W2008293484 @default.
- W4309659052 cites W2010417927 @default.
- W4309659052 cites W2016986234 @default.
- W4309659052 cites W2027042725 @default.
- W4309659052 cites W2031784014 @default.
- W4309659052 cites W2036555834 @default.
- W4309659052 cites W2037104078 @default.
- W4309659052 cites W2040649786 @default.
- W4309659052 cites W2042518400 @default.
- W4309659052 cites W2045407457 @default.
- W4309659052 cites W2048673557 @default.
- W4309659052 cites W2051379856 @default.
- W4309659052 cites W2057065562 @default.
- W4309659052 cites W2058647415 @default.
- W4309659052 cites W2062172666 @default.
- W4309659052 cites W2063963078 @default.
- W4309659052 cites W2065136366 @default.
- W4309659052 cites W2070272094 @default.
- W4309659052 cites W2076363539 @default.
- W4309659052 cites W2083099355 @default.
- W4309659052 cites W2086139571 @default.
- W4309659052 cites W2093120074 @default.
- W4309659052 cites W2099096938 @default.
- W4309659052 cites W2109216246 @default.
- W4309659052 cites W2112882050 @default.
- W4309659052 cites W2120423982 @default.
- W4309659052 cites W2126104386 @default.
- W4309659052 cites W2126525177 @default.
- W4309659052 cites W2130458932 @default.
- W4309659052 cites W2133466547 @default.
- W4309659052 cites W2134586420 @default.
- W4309659052 cites W2142827889 @default.
- W4309659052 cites W2143527146 @default.
- W4309659052 cites W2156150528 @default.
- W4309659052 cites W2159040523 @default.
- W4309659052 cites W2159914115 @default.
- W4309659052 cites W2165201727 @default.
- W4309659052 cites W2167579130 @default.
- W4309659052 cites W2194304382 @default.
- W4309659052 cites W2200719748 @default.
- W4309659052 cites W2203784432 @default.
- W4309659052 cites W2263275869 @default.
- W4309659052 cites W2289624033 @default.
- W4309659052 cites W2339734077 @default.
- W4309659052 cites W2342464430 @default.
- W4309659052 cites W2369595387 @default.
- W4309659052 cites W2406537281 @default.
- W4309659052 cites W2466989152 @default.
- W4309659052 cites W2468924201 @default.
- W4309659052 cites W2507936136 @default.
- W4309659052 cites W2512388909 @default.
- W4309659052 cites W2531991917 @default.
- W4309659052 cites W2557893886 @default.
- W4309659052 cites W2560494659 @default.
- W4309659052 cites W2582903515 @default.
- W4309659052 cites W2601221505 @default.
- W4309659052 cites W2601429811 @default.
- W4309659052 cites W2617171469 @default.
- W4309659052 cites W2624213438 @default.
- W4309659052 cites W2738794221 @default.
- W4309659052 cites W2755786988 @default.
- W4309659052 cites W2765525885 @default.
- W4309659052 cites W2788548733 @default.
- W4309659052 cites W2789034326 @default.
- W4309659052 cites W2789855059 @default.
- W4309659052 cites W2790995577 @default.
- W4309659052 cites W2800301228 @default.
- W4309659052 cites W2802563891 @default.
- W4309659052 cites W2803458146 @default.
- W4309659052 cites W2806974828 @default.
- W4309659052 cites W2884761043 @default.