Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309664593> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4309664593 endingPage "1616" @default.
- W4309664593 startingPage "1616" @default.
- W4309664593 abstract "Background: Malignant transformation (MT) of low-grade astrocytoma (LGA) produces a poor prognosis in benign tumors. Currently, variables linked with MT of LGA have proven equivocal. The present study aims to evaluate the risk variables, indicating that LGA gradually differentiates to malignant astrocytoma.Methods: Retrospective cohort analysis of LGA patients was performed. Both univariate and multivariate studies were used to discover variables connected to MT using the Cox regression method. As a result, the cumulative incidence of MT for each covariate survival curve was built after the final model.Results: In the current study, 115 individuals with LGA were included in the analysis, and MT was found in 16.5% of cases. In the case of MT, 68.4% of patients progressed to glioblastoma, whereas 31.6% progressed to anaplastic astrocytoma. Significant factors included supratentorial tumor (hazard ratio (HR) 3.41, 95% CI 1.18–12.10), midline shift > 5 mm (HR 7.15, 95% CI 2.28–34.33), and non-total resection as follows: subtotal resection (HR 5.09, 95% CI 0.07–24.02), partial resection (HR 1.61, 95% CI 1.09–24.11), and biopsy (HR 2.80, 95% CI 1.18–32.52).Conclusion: In individuals with LGA, MT dramatically altered the disease's natural history to a poor prognosis. The present study's analysis of the clinical features of patients indicated supratentorial LGA, a midline shift greater than 5 mm, and the degree of resection as risk factors for MT. The more extensive the resection, the greater the reduction in tumor load and MT. In addition, more molecular study is necessary to elucidate the pathophysiology of MT." @default.
- W4309664593 created "2022-11-29" @default.
- W4309664593 creator A5030784119 @default.
- W4309664593 date "2022-01-01" @default.
- W4309664593 modified "2023-10-14" @default.
- W4309664593 title "Malignant transformation in low-grade astrocytoma for long-term monitoring" @default.
- W4309664593 cites W2620142324 @default.
- W4309664593 cites W2783930020 @default.
- W4309664593 cites W2982723770 @default.
- W4309664593 cites W3005208085 @default.
- W4309664593 cites W3007870678 @default.
- W4309664593 cites W3023634639 @default.
- W4309664593 cites W4283768632 @default.
- W4309664593 doi "https://doi.org/10.4103/jcrt.jcrt_1469_20" @default.
- W4309664593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36412420" @default.
- W4309664593 hasPublicationYear "2022" @default.
- W4309664593 type Work @default.
- W4309664593 citedByCount "1" @default.
- W4309664593 countsByYear W43096645932023 @default.
- W4309664593 crossrefType "journal-article" @default.
- W4309664593 hasAuthorship W4309664593A5030784119 @default.
- W4309664593 hasBestOaLocation W43096645931 @default.
- W4309664593 hasConcept C10515644 @default.
- W4309664593 hasConcept C120665830 @default.
- W4309664593 hasConcept C121332964 @default.
- W4309664593 hasConcept C126322002 @default.
- W4309664593 hasConcept C141071460 @default.
- W4309664593 hasConcept C143998085 @default.
- W4309664593 hasConcept C144301174 @default.
- W4309664593 hasConcept C167135981 @default.
- W4309664593 hasConcept C207103383 @default.
- W4309664593 hasConcept C2778227246 @default.
- W4309664593 hasConcept C2778880634 @default.
- W4309664593 hasConcept C2779083369 @default.
- W4309664593 hasConcept C38180746 @default.
- W4309664593 hasConcept C44249647 @default.
- W4309664593 hasConcept C502942594 @default.
- W4309664593 hasConcept C50382708 @default.
- W4309664593 hasConcept C61511704 @default.
- W4309664593 hasConcept C71924100 @default.
- W4309664593 hasConcept C72563966 @default.
- W4309664593 hasConcept C88879693 @default.
- W4309664593 hasConcept C90924648 @default.
- W4309664593 hasConceptScore W4309664593C10515644 @default.
- W4309664593 hasConceptScore W4309664593C120665830 @default.
- W4309664593 hasConceptScore W4309664593C121332964 @default.
- W4309664593 hasConceptScore W4309664593C126322002 @default.
- W4309664593 hasConceptScore W4309664593C141071460 @default.
- W4309664593 hasConceptScore W4309664593C143998085 @default.
- W4309664593 hasConceptScore W4309664593C144301174 @default.
- W4309664593 hasConceptScore W4309664593C167135981 @default.
- W4309664593 hasConceptScore W4309664593C207103383 @default.
- W4309664593 hasConceptScore W4309664593C2778227246 @default.
- W4309664593 hasConceptScore W4309664593C2778880634 @default.
- W4309664593 hasConceptScore W4309664593C2779083369 @default.
- W4309664593 hasConceptScore W4309664593C38180746 @default.
- W4309664593 hasConceptScore W4309664593C44249647 @default.
- W4309664593 hasConceptScore W4309664593C502942594 @default.
- W4309664593 hasConceptScore W4309664593C50382708 @default.
- W4309664593 hasConceptScore W4309664593C61511704 @default.
- W4309664593 hasConceptScore W4309664593C71924100 @default.
- W4309664593 hasConceptScore W4309664593C72563966 @default.
- W4309664593 hasConceptScore W4309664593C88879693 @default.
- W4309664593 hasConceptScore W4309664593C90924648 @default.
- W4309664593 hasIssue "6" @default.
- W4309664593 hasLocation W43096645931 @default.
- W4309664593 hasLocation W43096645932 @default.
- W4309664593 hasOpenAccess W4309664593 @default.
- W4309664593 hasPrimaryLocation W43096645931 @default.
- W4309664593 hasRelatedWork W2088206352 @default.
- W4309664593 hasRelatedWork W2126210286 @default.
- W4309664593 hasRelatedWork W2130909087 @default.
- W4309664593 hasRelatedWork W2145587586 @default.
- W4309664593 hasRelatedWork W2361700749 @default.
- W4309664593 hasRelatedWork W2394214356 @default.
- W4309664593 hasRelatedWork W2770409748 @default.
- W4309664593 hasRelatedWork W3032885188 @default.
- W4309664593 hasRelatedWork W3086255011 @default.
- W4309664593 hasRelatedWork W4384497977 @default.
- W4309664593 hasVolume "18" @default.
- W4309664593 isParatext "false" @default.
- W4309664593 isRetracted "false" @default.
- W4309664593 workType "article" @default.