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- W4309665044 abstract "Abstract Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the ‘don’t-eat-me’ cell-surface molecule CD47 in small cell lung cancer (SCLC), a highly metastatic form of lung cancer. CD47 blockade potently enhances the local antitumor effects of radiotherapy in preclinical models of SCLC. Notably, CD47 blockade also stimulates off-target ‘abscopal’ effects inhibiting non-irradiated SCLC tumors in mice receiving radiation. These abscopal effects are independent of T cells but require macrophages that migrate into non-irradiated tumor sites in response to inflammatory signals produced by radiation and are locally activated by CD47 blockade to phagocytose cancer cells. Similar abscopal antitumor effects were observed in other cancer models treated with radiation and CD47 blockade. The systemic activation of antitumor macrophages following radiotherapy and CD47 blockade may be particularly important in patients with cancer who suffer from metastatic disease." @default.
- W4309665044 created "2022-11-29" @default.
- W4309665044 creator A5001069994 @default.
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- W4309665044 date "2022-11-21" @default.
- W4309665044 modified "2023-10-17" @default.
- W4309665044 title "Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect" @default.
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- W4309665044 doi "https://doi.org/10.1038/s43018-022-00456-0" @default.