Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309667648> ?p ?o ?g. }
- W4309667648 endingPage "e31013" @default.
- W4309667648 startingPage "e31013" @default.
- W4309667648 abstract "Chronic widespread pain (CWP), including fibromyalgia (FM), is characterized by generalized musculoskeletal pain and hyperalgesia. Plasma proteins from proteomics (non-targeted) and from targeted inflammatory panels (cytokines/chemokines) differentiate CWP/FM from controls. The importance of proteins obtained from these two sources, the protein-protein association network, and the biological processes involved were investigated. Plasma proteins from women with CWP (n = 15) and CON (n = 23) were analyzed using two-dimensional gel electrophoresis analysis and a multiplex proximity extension assay for analysis of cytokines/chemokines. Associations between the proteins and group were multivarietly analyzed. The protein-protein association network and the biological processes according to the Gene Ontology were investigated. Proteins from both sources were important for group differentiation; the majority from the two-dimensional gel electrophoresis analysis. 58 proteins significantly differentiated the two groups (R2 = 0.83). A significantly enriched network was found; biological processes were acute phase response, complement activation, and innate immune response. As with other studies, this study shows that plasma proteins can differentiate CWP from healthy subjects. Focusing on cytokines/chemokines is not sufficient to grasp the peripheral biological processes that maintain CWP/FM since our results show that other components of the immune and inflammation systems are also highly significant." @default.
- W4309667648 created "2022-11-29" @default.
- W4309667648 creator A5042420125 @default.
- W4309667648 creator A5048017178 @default.
- W4309667648 creator A5053825989 @default.
- W4309667648 creator A5054183848 @default.
- W4309667648 creator A5078576085 @default.
- W4309667648 creator A5084884436 @default.
- W4309667648 date "2022-11-18" @default.
- W4309667648 modified "2023-09-26" @default.
- W4309667648 title "Plasma proteins from several components of the immune system differentiate chronic widespread pain patients from healthy controls – an exploratory case-control study combining targeted and non-targeted protein identification" @default.
- W4309667648 cites W1440648612 @default.
- W4309667648 cites W1964744961 @default.
- W4309667648 cites W2036908922 @default.
- W4309667648 cites W2050718087 @default.
- W4309667648 cites W2059634785 @default.
- W4309667648 cites W2060053586 @default.
- W4309667648 cites W2061843589 @default.
- W4309667648 cites W2065028487 @default.
- W4309667648 cites W2076756153 @default.
- W4309667648 cites W2081210528 @default.
- W4309667648 cites W2086134310 @default.
- W4309667648 cites W2091291518 @default.
- W4309667648 cites W2103654910 @default.
- W4309667648 cites W2105786999 @default.
- W4309667648 cites W2152611039 @default.
- W4309667648 cites W2166281097 @default.
- W4309667648 cites W2206572452 @default.
- W4309667648 cites W2253364553 @default.
- W4309667648 cites W2268320933 @default.
- W4309667648 cites W2326319948 @default.
- W4309667648 cites W2331413527 @default.
- W4309667648 cites W2331694814 @default.
- W4309667648 cites W2414635989 @default.
- W4309667648 cites W2415752306 @default.
- W4309667648 cites W2488237492 @default.
- W4309667648 cites W2568687592 @default.
- W4309667648 cites W2592360091 @default.
- W4309667648 cites W2593025118 @default.
- W4309667648 cites W2596033074 @default.
- W4309667648 cites W2605189579 @default.
- W4309667648 cites W2605909806 @default.
- W4309667648 cites W2625123770 @default.
- W4309667648 cites W2738410425 @default.
- W4309667648 cites W2786697307 @default.
- W4309667648 cites W2790063417 @default.
- W4309667648 cites W2793188940 @default.
- W4309667648 cites W2793570991 @default.
- W4309667648 cites W2797510283 @default.
- W4309667648 cites W2800458841 @default.
- W4309667648 cites W2806352063 @default.
- W4309667648 cites W2883715294 @default.
- W4309667648 cites W2884937801 @default.
- W4309667648 cites W2885870007 @default.
- W4309667648 cites W2891285073 @default.
- W4309667648 cites W2892426195 @default.
- W4309667648 cites W2900569176 @default.
- W4309667648 cites W2901443756 @default.
- W4309667648 cites W2902019439 @default.
- W4309667648 cites W2913527157 @default.
- W4309667648 cites W2913543761 @default.
- W4309667648 cites W2921726292 @default.
- W4309667648 cites W2922032042 @default.
- W4309667648 cites W2924236478 @default.
- W4309667648 cites W2931155919 @default.
- W4309667648 cites W2940735269 @default.
- W4309667648 cites W2942513301 @default.
- W4309667648 cites W2946958006 @default.
- W4309667648 cites W2948075606 @default.
- W4309667648 cites W2964507930 @default.
- W4309667648 cites W2970499521 @default.
- W4309667648 cites W2973744419 @default.
- W4309667648 cites W2997757166 @default.
- W4309667648 cites W3008279131 @default.
- W4309667648 cites W3018877629 @default.
- W4309667648 cites W3029952204 @default.
- W4309667648 cites W3044024306 @default.
- W4309667648 cites W3044078674 @default.
- W4309667648 cites W3044900990 @default.
- W4309667648 cites W3046945465 @default.
- W4309667648 cites W3110917833 @default.
- W4309667648 cites W3128368348 @default.
- W4309667648 cites W3136284627 @default.
- W4309667648 cites W3159008831 @default.
- W4309667648 cites W3161575893 @default.
- W4309667648 cites W3174972846 @default.
- W4309667648 cites W3194051943 @default.
- W4309667648 cites W819018147 @default.
- W4309667648 doi "https://doi.org/10.1097/md.0000000000031013" @default.
- W4309667648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36401429" @default.
- W4309667648 hasPublicationYear "2022" @default.
- W4309667648 type Work @default.
- W4309667648 citedByCount "0" @default.
- W4309667648 crossrefType "journal-article" @default.
- W4309667648 hasAuthorship W4309667648A5042420125 @default.
- W4309667648 hasAuthorship W4309667648A5048017178 @default.
- W4309667648 hasAuthorship W4309667648A5053825989 @default.
- W4309667648 hasAuthorship W4309667648A5054183848 @default.