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• W4309674003 abstract "A new andrographolide-based terminal alkyne 3 was synthesized in good yield from deoxy-andrographolide 2, obtained from a natural compound andrographolide 1, which in turn was isolated from the leaves of the plant Andrographis paniculata. Copper(I)-catalyzed azide-alkyne cycloaddition reaction of alkyne 3 with azido-sugars 4a-f furnished a library of andrographolide-fastened triazolyl glycoconjugates 5a-f in good yields. The structures of these semisynthetic andrographolide derivatives were established by Fourier transform infrared, NMR, and mass spectroscopy. The compounds 5a-f were further evaluated against Alzheimer's disease (AD) using a scopolamine (SCOP)-induced memory impairment mice model. It was observed that antioxidant and anticholinesterase properties of these compounds contribute significantly toward their remarkable potential to improve cognitive functioning." @default.
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• W4309674003 date "2022-11-22" @default.
• W4309674003 modified "2023-10-12" @default.
• W4309674003 title "Synthesis of <i>deoxy</i>-Andrographolide Triazolyl Glycoconjugates for the Treatment of Alzheimer’s Disease" @default.
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• W4309674003 doi "https://doi.org/10.1021/acschemneuro.2c00328" @default.
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