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- W4309681929 abstract "Summary Anopheles mosquitoes, as vectors for the malaria parasite, are a global threat to human health. To find and bite a human, they utilize neurons within their sensory appendages. However, the identity and quantification of sensory appendage neurons are lacking. Here we use a neurogenetic approach to label all neurons in Anopheles coluzzii mosquitoes. We utilize the Homology Assisted CRISPR Knock-in (HACK) approach to generate a T2A-QF2 w knock-in of the synaptic gene bruchpilot . We use a membrane-targeted GFP reporter to visualize the neurons in the brain and to quantify neurons in all major chemosensory appendages (antenna, maxillary palp, labella, tarsi). By comparing labeling of brp>GFP and Orco>GFP mosquitoes, we predict the extent of neurons expressing Ionotropic Receptors or other chemosensory receptors. This work introduces a valuable genetic tool for the functional analysis of Anopheles mosquito neurobiology and initiates characterization of the sensory neurons that guide mosquito behavior. Graphical Abstract" @default.
- W4309681929 created "2022-11-29" @default.
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- W4309681929 date "2022-11-22" @default.
- W4309681929 modified "2023-10-16" @default.
- W4309681929 title "Neurogenetic identification of mosquito sensory neurons" @default.
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- W4309681929 doi "https://doi.org/10.1101/2022.11.22.517370" @default.
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