FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309683984> ?p ?o ?g. }

• W4309683984 endingPage "5038" @default.
• W4309683984 startingPage "5038" @default.
• W4309683984 abstract "In this study, a novel polymeric nanomaterial was synthesized and characterized, and it its potential usability in hypertension treatment was demonstrated. For these purposes, a poly(hydroxyethyl methacrylate-methacryloylamidophenylalanine)-based polymeric nanomaterial (p(HEMPA)) was synthesized using a mini-emulsion polymerization technique. The nanomaterials were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and zeta size analysis. The synthesized p(HEMPA) nanomaterial had a diameter of about 113 nm. Amlodipine-binding studies were optimized by changing the reaction conditions. Under optimum conditions, amlodipine's maximum adsorption value (Qmax) of the p(HEMPA) nanopolymer was found to be 145.8 mg/g. In vitro controlled drug release rates of amlodipine, bound to the nanopolymer at the optimum conditions, were studied with the dialysis method in a simulated gastrointestinal system with pH values of 1.2, 6.8 and 7.4. It was found that 99.5% of amlodipine loaded on the nanomaterial was released at pH 7.4 and 72 h. Even after 72 h, no difference was observed in the release of AML. It can be said that the synthesized nanomaterial is suitable for oral amlodipine release. In conclusion, the synthesized nanomaterial was studied for the first time in the literature as a drug delivery system for use in the treatment of hypertension. In addition, AML-p(HEMPA) nanomaterials may enable less frequent drug uptake, have higher bioavailability, and allow for prolonged release with minimal side effects." @default.
• W4309683984 created "2022-11-29" @default.
• W4309683984 creator A5031103937 @default.
• W4309683984 creator A5034325185 @default.
• W4309683984 creator A5043112650 @default.
• W4309683984 creator A5046860311 @default.
• W4309683984 creator A5059728120 @default.
• W4309683984 creator A5070678346 @default.
• W4309683984 creator A5071755485 @default.
• W4309683984 creator A5079634366 @default.
• W4309683984 creator A5081068525 @default.
• W4309683984 date "2022-11-21" @default.
• W4309683984 modified "2023-09-30" @default.
• W4309683984 title "Novel Polymeric Nanomaterial Based on Poly(Hydroxyethyl Methacrylate-Methacryloylamidophenylalanine) for Hypertension Treatment: Properties and Drug Release Characteristics" @default.
• W4309683984 cites W1967422125 @default.
• W4309683984 cites W1972581049 @default.
• W4309683984 cites W1979155410 @default.
• W4309683984 cites W1992797567 @default.
• W4309683984 cites W2010654277 @default.
• W4309683984 cites W2025631096 @default.
• W4309683984 cites W2043894518 @default.
• W4309683984 cites W2054100802 @default.
• W4309683984 cites W2068548780 @default.
• W4309683984 cites W2085987399 @default.
• W4309683984 cites W2086912531 @default.
• W4309683984 cites W2087761646 @default.
• W4309683984 cites W2090083795 @default.
• W4309683984 cites W2123933804 @default.
• W4309683984 cites W2167122213 @default.
• W4309683984 cites W2251264873 @default.
• W4309683984 cites W2317217624 @default.
• W4309683984 cites W2398744072 @default.
• W4309683984 cites W2463873154 @default.
• W4309683984 cites W2548963507 @default.
• W4309683984 cites W2884740957 @default.
• W4309683984 cites W2899667629 @default.
• W4309683984 cites W2900376430 @default.
• W4309683984 cites W2911995450 @default.
• W4309683984 cites W2923209191 @default.
• W4309683984 cites W2924617004 @default.
• W4309683984 cites W2949564053 @default.
• W4309683984 cites W3004465995 @default.
• W4309683984 cites W3039646636 @default.
• W4309683984 cites W3112035152 @default.
• W4309683984 cites W3119040830 @default.
• W4309683984 cites W3176197627 @default.
• W4309683984 cites W333747931 @default.
• W4309683984 cites W85616151 @default.
• W4309683984 doi "https://doi.org/10.3390/polym14225038" @default.
• W4309683984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36433166" @default.
• W4309683984 hasPublicationYear "2022" @default.
• W4309683984 type Work @default.
• W4309683984 citedByCount "0" @default.
• W4309683984 crossrefType "journal-article" @default.
• W4309683984 hasAuthorship W4309683984A5031103937 @default.
• W4309683984 hasAuthorship W4309683984A5034325185 @default.
• W4309683984 hasAuthorship W4309683984A5043112650 @default.
• W4309683984 hasAuthorship W4309683984A5046860311 @default.
• W4309683984 hasAuthorship W4309683984A5059728120 @default.
• W4309683984 hasAuthorship W4309683984A5070678346 @default.
• W4309683984 hasAuthorship W4309683984A5071755485 @default.
• W4309683984 hasAuthorship W4309683984A5079634366 @default.
• W4309683984 hasAuthorship W4309683984A5081068525 @default.
• W4309683984 hasBestOaLocation W43096839841 @default.
• W4309683984 hasConcept C127413603 @default.
• W4309683984 hasConcept C132050475 @default.
• W4309683984 hasConcept C138631740 @default.
• W4309683984 hasConcept C13965031 @default.
• W4309683984 hasConcept C155672457 @default.
• W4309683984 hasConcept C159985019 @default.
• W4309683984 hasConcept C160892712 @default.
• W4309683984 hasConcept C171250308 @default.
• W4309683984 hasConcept C181389837 @default.
• W4309683984 hasConcept C185592680 @default.
• W4309683984 hasConcept C192562407 @default.
• W4309683984 hasConcept C2779820397 @default.
• W4309683984 hasConcept C42360764 @default.
• W4309683984 hasConcept C44228677 @default.
• W4309683984 hasConcept C521977710 @default.
• W4309683984 hasConcept C71924100 @default.
• W4309683984 hasConcept C86181022 @default.
• W4309683984 hasConcept C98274493 @default.
• W4309683984 hasConceptScore W4309683984C127413603 @default.
• W4309683984 hasConceptScore W4309683984C132050475 @default.
• W4309683984 hasConceptScore W4309683984C138631740 @default.
• W4309683984 hasConceptScore W4309683984C13965031 @default.
• W4309683984 hasConceptScore W4309683984C155672457 @default.
• W4309683984 hasConceptScore W4309683984C159985019 @default.
• W4309683984 hasConceptScore W4309683984C160892712 @default.
• W4309683984 hasConceptScore W4309683984C171250308 @default.
• W4309683984 hasConceptScore W4309683984C181389837 @default.
• W4309683984 hasConceptScore W4309683984C185592680 @default.
• W4309683984 hasConceptScore W4309683984C192562407 @default.
• W4309683984 hasConceptScore W4309683984C2779820397 @default.
• W4309683984 hasConceptScore W4309683984C42360764 @default.
• W4309683984 hasConceptScore W4309683984C44228677 @default.
• W4309683984 hasConceptScore W4309683984C521977710 @default.
• W4309683984 hasConceptScore W4309683984C71924100 @default.

• next