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- W4309685823 abstract "The accumulation of oxidative DNA base damage can severely disrupt the integrity of the genome and is strongly associated with the development of cancer. DNA glycosylase is the critical enzyme that initiates the base excision repair (BER) pathway, recognizing and excising damaged bases. The Nei endonuclease VIII-like 3 (NEIL3) is an emerging DNA glycosylase essential in maintaining genome stability. With an in-depth study of the structure and function of NEIL3, we found that it has properties related to the process of base damage repair. For example, it not only prefers the base damage of single-stranded DNA (ssDNA), G-quadruplex and DNA interstrand crosslinks (ICLs), but also participates in the maintenance of replication fork stability and telomere integrity. In addition, NEIL3 is strongly associated with the progression of cancers and cardiovascular and neurological diseases, is incredibly significantly overexpressed in cancers, and may become an independent prognostic marker for cancer patients. Interestingly, circNEIL3, a circular RNA of exon-encoded origin by NEIL3, also promotes the development of multiple cancers. In this review, we have summarized the structure and the characteristics of NEIL3 to repair base damage. We have focused on NEIL3 and circNEIL3 in cancer development, progression and prognosis." @default.
- W4309685823 created "2022-11-29" @default.
- W4309685823 creator A5006346410 @default.
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- W4309685823 creator A5091603789 @default.
- W4309685823 date "2022-11-22" @default.
- W4309685823 modified "2023-10-12" @default.
- W4309685823 title "Biological Functions of the DNA Glycosylase NEIL3 and Its Role in Disease Progression Including Cancer" @default.
- W4309685823 cites W1614551514 @default.
- W4309685823 cites W1914649288 @default.
- W4309685823 cites W1949858629 @default.
- W4309685823 cites W1976987484 @default.
- W4309685823 cites W1984309374 @default.
- W4309685823 cites W1984373702 @default.
- W4309685823 cites W1989400378 @default.
- W4309685823 cites W1992410391 @default.
- W4309685823 cites W1994873752 @default.
- W4309685823 cites W1998546184 @default.
- W4309685823 cites W2003667713 @default.
- W4309685823 cites W2004125597 @default.
- W4309685823 cites W2010339813 @default.
- W4309685823 cites W2013499563 @default.
- W4309685823 cites W2015174754 @default.
- W4309685823 cites W2015626135 @default.
- W4309685823 cites W2021711239 @default.
- W4309685823 cites W2026273332 @default.
- W4309685823 cites W2026370504 @default.
- W4309685823 cites W2037023386 @default.
- W4309685823 cites W2047276247 @default.
- W4309685823 cites W2049757552 @default.
- W4309685823 cites W2059306569 @default.
- W4309685823 cites W2061764665 @default.
- W4309685823 cites W2061919040 @default.
- W4309685823 cites W2069357463 @default.
- W4309685823 cites W2070888848 @default.
- W4309685823 cites W2073469597 @default.
- W4309685823 cites W2078705269 @default.
- W4309685823 cites W2079658347 @default.
- W4309685823 cites W2083597940 @default.
- W4309685823 cites W2084505555 @default.
- W4309685823 cites W2087753682 @default.
- W4309685823 cites W2090219305 @default.
- W4309685823 cites W2092243219 @default.
- W4309685823 cites W2092883271 @default.
- W4309685823 cites W2093815328 @default.
- W4309685823 cites W2094204421 @default.
- W4309685823 cites W2102829872 @default.
- W4309685823 cites W2104584181 @default.
- W4309685823 cites W2114578754 @default.
- W4309685823 cites W2132747764 @default.
- W4309685823 cites W2146997637 @default.
- W4309685823 cites W2172060739 @default.
- W4309685823 cites W2195613597 @default.
- W4309685823 cites W2203735107 @default.
- W4309685823 cites W2288234973 @default.
- W4309685823 cites W2340502977 @default.
- W4309685823 cites W2407591950 @default.
- W4309685823 cites W2472114891 @default.
- W4309685823 cites W2513005555 @default.
- W4309685823 cites W2525711566 @default.
- W4309685823 cites W2531428131 @default.
- W4309685823 cites W2556496438 @default.
- W4309685823 cites W2568817474 @default.
- W4309685823 cites W2590140128 @default.
- W4309685823 cites W2590327834 @default.
- W4309685823 cites W2605152472 @default.
- W4309685823 cites W2648905444 @default.
- W4309685823 cites W2733153170 @default.
- W4309685823 cites W2751221573 @default.
- W4309685823 cites W2754241980 @default.
- W4309685823 cites W2755156122 @default.
- W4309685823 cites W2773622363 @default.
- W4309685823 cites W2775504460 @default.
- W4309685823 cites W2797633816 @default.
- W4309685823 cites W2806267204 @default.
- W4309685823 cites W2919113889 @default.
- W4309685823 cites W2920607742 @default.
- W4309685823 cites W2940512444 @default.
- W4309685823 cites W2947780266 @default.
- W4309685823 cites W2954614079 @default.
- W4309685823 cites W2963850569 @default.
- W4309685823 cites W2967043226 @default.
- W4309685823 cites W2987058388 @default.
- W4309685823 cites W3002698677 @default.
- W4309685823 cites W3023297147 @default.
- W4309685823 cites W3049724160 @default.
- W4309685823 cites W3081765743 @default.
- W4309685823 cites W3106706416 @default.
- W4309685823 cites W3120621442 @default.
- W4309685823 cites W3126741142 @default.
- W4309685823 cites W3128142356 @default.
- W4309685823 cites W3128646645 @default.
- W4309685823 cites W3129421182 @default.