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- W4309686052 endingPage "14503" @default.
- W4309686052 startingPage "14503" @default.
- W4309686052 abstract "As a widely prescribed anti-diabetic drug, metformin has been receiving novel attention for its analgesic potential. In the study of the complex etiology of neuropathic pain (NeP), male and female individuals exhibit quite different responses characterized by higher pain sensitivity and greater NeP incidence in women. This “gender gap” in our knowledge of sex differences in pain processing strongly limits the sex-oriented treatment of patients suffering from NeP. Besides, the current investigation of the analgesic potential of metformin has not addressed the “gender gap” problem. Hence, this study focuses on metformin and sex-dependent analgesia in a murine model of NeP induced by chronic constriction injury of the sciatic nerve. We investigated sexual dimorphism in signaling pathways involved by 7 days of metformin administration, such as changes in AMP-activated protein kinase and the positive regulation of autophagy machinery, discovering that metformin affected in a sexually dimorphic manner the immunological and inflammatory response to nerve lesion. These effects were complemented by morphological and adaptive changes occurring after peripheral nerve injury. Altogether these data can contribute to explaining a number of potential mechanisms responsible for the complete recovery from NeP found in male mice, as opposed to the failure of long-lasting recovery in female animals." @default.
- W4309686052 created "2022-11-29" @default.
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- W4309686052 date "2022-11-22" @default.
- W4309686052 modified "2023-10-18" @default.
- W4309686052 title "Sex Differences in Neuropathy: The Paradigmatic Case of MetFormin" @default.
- W4309686052 cites W1523693806 @default.
- W4309686052 cites W1603046163 @default.
- W4309686052 cites W1784352764 @default.
- W4309686052 cites W1926156811 @default.
- W4309686052 cites W1965357024 @default.
- W4309686052 cites W1970637701 @default.
- W4309686052 cites W1974613322 @default.
- W4309686052 cites W1974642534 @default.
- W4309686052 cites W1978130724 @default.
- W4309686052 cites W1980687166 @default.
- W4309686052 cites W1984680773 @default.
- W4309686052 cites W1985208991 @default.
- W4309686052 cites W1987155536 @default.
- W4309686052 cites W1990445317 @default.
- W4309686052 cites W1995069275 @default.
- W4309686052 cites W2004478056 @default.
- W4309686052 cites W2027889563 @default.
- W4309686052 cites W2029227926 @default.
- W4309686052 cites W2036755369 @default.
- W4309686052 cites W2045032238 @default.
- W4309686052 cites W2055343760 @default.
- W4309686052 cites W2056763584 @default.
- W4309686052 cites W2057123987 @default.
- W4309686052 cites W2057674925 @default.
- W4309686052 cites W2058020736 @default.
- W4309686052 cites W2059396054 @default.
- W4309686052 cites W2077580553 @default.
- W4309686052 cites W2078852360 @default.
- W4309686052 cites W2080085015 @default.
- W4309686052 cites W2085462226 @default.
- W4309686052 cites W2087454739 @default.
- W4309686052 cites W2113935443 @default.
- W4309686052 cites W2126974532 @default.
- W4309686052 cites W2130330606 @default.
- W4309686052 cites W2131923927 @default.
- W4309686052 cites W2136882542 @default.
- W4309686052 cites W2138226825 @default.
- W4309686052 cites W2140406095 @default.
- W4309686052 cites W2142237270 @default.
- W4309686052 cites W2154798479 @default.
- W4309686052 cites W2162739063 @default.
- W4309686052 cites W2224283033 @default.
- W4309686052 cites W2473725818 @default.
- W4309686052 cites W2610769987 @default.
- W4309686052 cites W2613532744 @default.
- W4309686052 cites W2624598325 @default.
- W4309686052 cites W2748205638 @default.
- W4309686052 cites W2771826181 @default.
- W4309686052 cites W2874520653 @default.
- W4309686052 cites W2888308652 @default.
- W4309686052 cites W2888775081 @default.
- W4309686052 cites W2899070315 @default.
- W4309686052 cites W2900519886 @default.
- W4309686052 cites W2904291679 @default.
- W4309686052 cites W2905289338 @default.
- W4309686052 cites W2906336301 @default.
- W4309686052 cites W2918157477 @default.
- W4309686052 cites W2930966192 @default.
- W4309686052 cites W2937270878 @default.
- W4309686052 cites W2938758635 @default.
- W4309686052 cites W2969737775 @default.
- W4309686052 cites W2971332774 @default.
- W4309686052 cites W2998718682 @default.
- W4309686052 cites W3004807482 @default.
- W4309686052 cites W3010443092 @default.
- W4309686052 cites W3011875247 @default.
- W4309686052 cites W3019800544 @default.
- W4309686052 cites W3023170535 @default.
- W4309686052 cites W3049167578 @default.
- W4309686052 cites W3109152315 @default.
- W4309686052 cites W3127799913 @default.
- W4309686052 cites W3128643350 @default.
- W4309686052 cites W3145702068 @default.
- W4309686052 cites W3158428924 @default.
- W4309686052 cites W3169843530 @default.
- W4309686052 cites W3183294886 @default.
- W4309686052 cites W3187589847 @default.
- W4309686052 cites W3199510603 @default.
- W4309686052 cites W3202535675 @default.
- W4309686052 cites W3205027932 @default.
- W4309686052 cites W396067388 @default.
- W4309686052 cites W4320288039 @default.
- W4309686052 doi "https://doi.org/10.3390/ijms232314503" @default.
- W4309686052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36498830" @default.
- W4309686052 hasPublicationYear "2022" @default.