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• W4309691364 endingPage "E408" @default.
• W4309691364 startingPage "E393" @default.
• W4309691364 abstract "<h3>Background:</h3> To study whether there is genetic overlap underlying the risk for schizophrenia spectrum disorders (SSDs) and low intelligence quotient (IQ), we reviewed and summarized the evidence on genetic variants associated with both traits. <h3>Methods:</h3> We performed this review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and preregistered it in PROSPERO. We searched the Medline databases via PubMed, PsycInfo, Web of Science and Scopus. We included studies in adults with a diagnosis of SSD that explored genetic variants (single nucleotide polymorphisms [SNPs], copy number variants [CNVs], genomic insertions or genomic deletions), estimated IQ and studied the relationship between genetic variability and both traits (SSD and IQ). We synthesized the results and assessed risk of bias using the Quality of Genetic Association Studies (Q-Genie) tool. <h3>Results:</h3> Fifty-five studies met the inclusion criteria (45 case–control, 9 cross-sectional, 1 cohort), of which 55% reported significant associations for genetic variants involved in IQ and SSD. The SNPs more frequently explored through candidate gene studies were in <i>COMT</i>, <i>DTNBP1</i>, <i>BDNF</i> and <i>TCF4</i>. Through genome-wide association studies, 2 SNPs in <i>CHD7</i> and <i>GATAD2A</i> were associated with IQ in patients with SSD. The studies on CNVs suggested significant associations between structural variants and low IQ in patients with SSD. <h3>Limitations:</h3> Overall, primary studies used heterogeneous IQ measurement tools and had small samples. Grey literature was not screened. <h3>Conclusion:</h3> Genetic overlap between SSD and IQ supports the neurodevelopmental hypothesis of schizophrenia. Most of the risk polymorphisms identified were in genes relevant to brain development, neural proliferation and differentiation, and synaptic plasticity." @default.
• W4309691364 created "2022-11-29" @default.
• W4309691364 creator A5008352300 @default.
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• W4309691364 creator A5075914744 @default.
• W4309691364 date "2022-11-22" @default.
• W4309691364 modified "2023-10-01" @default.
• W4309691364 title "Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review" @default.
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