FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309693813> ?p ?o ?g. }

• W4309693813 endingPage "100629" @default.
• W4309693813 startingPage "100629" @default.
• W4309693813 abstract "When listing for liver transplantation, one can transplant as soon as possible or introduce a test-of-time to better select patients, as the tumor's biological behavior is observed. Knowing the degree of harm caused by time itself is essential to advise patients and decide on the maximum duration of the test-of-time. Therefore, we investigated the causal effect of waiting time on post-transplant survival for patients with hepatocellular carcinoma.We analyzed the UNOS-OPTN dataset and exploited a natural experiment created by blood groups. Relations between variables and assumptions were described in a causal graph. Selection bias was addressed by inverse probability weighting. Confounding was avoided using instrumental variable analysis, with an additive hazards model in the second stage. The causal effect was evaluated by estimating the difference in 5-year overall survival if all patients waited 2 months instead of 12 months. Upper bounds of the test-of-time were evaluated for probable scenarios by means of simulation.The F-statistic of the first stage was 86.3. The effect of waiting 12 months vs. 2 months corresponded with a drop in overall survival rate of 5.07% (95% CI 0.277-9.69) and 8.33% (95% CI 0.47-15.60) at 5- and 10-years post-transplant, respectively. The median survival dropped by 3.41 years from 16.21 years (95% CI 15.98-16.60) for those waiting 2 months to 12.80 years (95% CI 10.72-15.90) for those waiting 12 months.From a patient's perspective, the choice between ablate-and-wait vs. immediate transplantation is in favor of immediate transplantation. From a policy perspective, the extra waiting time can be used to increase the utility of scarce donor livers. However, the duration of the test-of-time is bounded, and it likely should not exceed 8 months.When listing patients with liver cancer for transplantation, it is unclear whether a test-of-time or immediate transplantation offer better outcomes at the population level. In this study, we found that increased liver transplant waiting times are detrimental in patients with liver cancer. Furthermore, our simulation showed that a pre-operative observational period can be useful to ensure good donor liver allocation, but that its duration should not exceed 8 months." @default.
• W4309693813 created "2022-11-29" @default.
• W4309693813 creator A5001948901 @default.
• W4309693813 creator A5004074611 @default.
• W4309693813 creator A5005200745 @default.
• W4309693813 creator A5055559412 @default.
• W4309693813 creator A5060612208 @default.
• W4309693813 creator A5068166194 @default.
• W4309693813 creator A5086856138 @default.
• W4309693813 date "2023-02-01" @default.
• W4309693813 modified "2023-10-14" @default.
• W4309693813 title "Impact of waiting time on post-transplant survival for recipients with hepatocellular carcinoma: A natural experiment randomized by blood group" @default.
• W4309693813 cites W1976534836 @default.
• W4309693813 cites W1978209044 @default.
• W4309693813 cites W1985804894 @default.
• W4309693813 cites W198665498 @default.
• W4309693813 cites W2009933870 @default.
• W4309693813 cites W2025099514 @default.
• W4309693813 cites W2030177538 @default.
• W4309693813 cites W2030347107 @default.
• W4309693813 cites W2039064487 @default.
• W4309693813 cites W2059796825 @default.
• W4309693813 cites W2106459311 @default.
• W4309693813 cites W2115448469 @default.
• W4309693813 cites W2117676461 @default.
• W4309693813 cites W2125264268 @default.
• W4309693813 cites W2130862142 @default.
• W4309693813 cites W2133494987 @default.
• W4309693813 cites W2146317473 @default.
• W4309693813 cites W2160579250 @default.
• W4309693813 cites W2183370948 @default.
• W4309693813 cites W2194364505 @default.
• W4309693813 cites W2295447825 @default.
• W4309693813 cites W2597503617 @default.
• W4309693813 cites W2603017800 @default.
• W4309693813 cites W2743587886 @default.
• W4309693813 cites W2801778185 @default.
• W4309693813 cites W3012048972 @default.
• W4309693813 cites W4246239836 @default.
• W4309693813 doi "https://doi.org/10.1016/j.jhepr.2022.100629" @default.
• W4309693813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36654943" @default.
• W4309693813 hasPublicationYear "2023" @default.
• W4309693813 type Work @default.
• W4309693813 citedByCount "0" @default.
• W4309693813 crossrefType "journal-article" @default.
• W4309693813 hasAuthorship W4309693813A5001948901 @default.
• W4309693813 hasAuthorship W4309693813A5004074611 @default.
• W4309693813 hasAuthorship W4309693813A5005200745 @default.
• W4309693813 hasAuthorship W4309693813A5055559412 @default.
• W4309693813 hasAuthorship W4309693813A5060612208 @default.
• W4309693813 hasAuthorship W4309693813A5068166194 @default.
• W4309693813 hasAuthorship W4309693813A5086856138 @default.
• W4309693813 hasBestOaLocation W43096938131 @default.
• W4309693813 hasConcept C126322002 @default.
• W4309693813 hasConcept C2778019345 @default.
• W4309693813 hasConcept C71924100 @default.
• W4309693813 hasConcept C77350462 @default.
• W4309693813 hasConceptScore W4309693813C126322002 @default.
• W4309693813 hasConceptScore W4309693813C2778019345 @default.
• W4309693813 hasConceptScore W4309693813C71924100 @default.
• W4309693813 hasConceptScore W4309693813C77350462 @default.
• W4309693813 hasIssue "2" @default.
• W4309693813 hasLocation W43096938131 @default.
• W4309693813 hasLocation W43096938132 @default.
• W4309693813 hasLocation W43096938133 @default.
• W4309693813 hasLocation W43096938134 @default.
• W4309693813 hasLocation W43096938135 @default.
• W4309693813 hasOpenAccess W4309693813 @default.
• W4309693813 hasPrimaryLocation W43096938131 @default.
• W4309693813 hasRelatedWork W1506200166 @default.
• W4309693813 hasRelatedWork W1995515455 @default.
• W4309693813 hasRelatedWork W2080531066 @default.
• W4309693813 hasRelatedWork W2748952813 @default.
• W4309693813 hasRelatedWork W2766588635 @default.
• W4309693813 hasRelatedWork W2899084033 @default.
• W4309693813 hasRelatedWork W3029422704 @default.
• W4309693813 hasRelatedWork W3031052312 @default.
• W4309693813 hasRelatedWork W3032375762 @default.
• W4309693813 hasRelatedWork W3108674512 @default.
• W4309693813 hasVolume "5" @default.
• W4309693813 isParatext "false" @default.
• W4309693813 isRetracted "false" @default.
• W4309693813 workType "article" @default.