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• W4309697704 abstract "Abstract While altered protein glycosylation is regarded a trait of oral squamous cell carcinoma (OSCC), its heterogeneous glycoproteome and dynamics with disease progression remain unmapped. To this end, we here employ an integrated multi-omics approach comprising unbiased and quantitative glycomics and glycoproteomics applied to a valuable cohort of resected tumour tissues from OSCC patients with (n = 19) and without (n = 12) lymph node metastasis. While all tumour tissues displayed uniform N -glycome profiles suggesting relatively stable global N -glycosylation during lymph node metastasis, glycoproteomics and advanced correlation analysis notably uncovered altered site-specific N -glycosylation and previously unknown associations with several key clinicopathological features. Importantly, focused analyses of the multi-omics data unveiled two N -glycans and three N -glycopeptides that were closely associated with patient survival. This study provides novel insight into the complex OSCC tissue N -glycoproteome forming an important resource to further explore the underpinning disease mechanisms and uncover new prognostic glyco-markers for OSCC. Teaser Deep survey of the dynamic landscape of complex sugars in oral tumours paves a way for new prognostic disease markers." @default.
• W4309697704 created "2022-11-29" @default.
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• W4309697704 date "2022-11-22" @default.
• W4309697704 modified "2023-10-17" @default.
• W4309697704 title "Comprehensive glycoprofiling of oral tumours associates<i>N</i>-glycosylation with lymph node metastasis and patient survival" @default.
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• W4309697704 doi "https://doi.org/10.1101/2022.11.21.517331" @default.
• W4309697704 hasPublicationYear "2022" @default.
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