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• W4309697728 abstract "Introduction Gestational chronodisruption impact maternal circadian rhythms, inhibiting the nocturnal increase of melatonin, a critical hormone that contributes to maternal changes adaptation, entrains circadian rhythms, and prepares the fetus for birth and successful health in adulthood. In rats, we know that gestational chronodisruption by maternal chronic photoperiod shifting (CPS) impaired maternal melatonin levels and resulted in long-term metabolic and cardiovascular effects in adult male offspring. Here, we investigated the consequences of CPS on mother and adult female offspring and explored the effects of melatonin maternal supplementation. Also, we tested whether maternal melatonin administration during gestational chronodisruption rescues maternal circadian rhythms, pregnancy outcomes, and transcriptional functions in adult female offspring. Methods Female rats raised and maintained in photoperiod 12:12 light: dark were mated and separated into three groups: (a) Control photoperiod 12:12 (LD); (b) CPS photoperiod; and (c) CPS+Mel mothers supplemented with melatonin in the drinking water throughout gestation. In the mother, we evaluated maternal circadian rhythms by telemetry and pregnancy outcomes, in the long-term, we study adult female offspring by evaluating endocrine and inflammatory markers and the mRNA expression of functional genes involved in adrenal, cardiac, and renal function. Results In the mothers, CPS disrupted circadian rhythms of locomotor activity, body temperature, and heart rate and increased gestational length by almost 12-h and birth weight by 12%, all of which were rescued by maternal melatonin administration. In the female offspring, we found blunted day/night differences in circulating levels of melatonin and corticosterone, abnormal patterns of pro-inflammatory cytokines Interleukin-1a (IL1a), Interleukin-6 (IL6), and Interleukin-10 (IL10); and differential expression in 18 out of 24 adrenal, cardiac, and renal mRNAs evaluated. Conclusion Maternal melatonin contributed to maintaining the maternal circadian rhythms in mothers exposed to CPS, and the re-establishing the expression of 60% of the altered mRNAs to control levels in the female offspring. Although we did not analyze the effects on kidney, adrenal, and heart physiology, our results reinforce the idea that altered maternal circadian rhythms, resulting from exposure to light at night, should be a mechanism involved in the programming of Non-Communicable Diseases." @default.
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• W4309697728 date "2022-11-23" @default.
• W4309697728 modified "2023-10-18" @default.
• W4309697728 title "Maternal melatonin treatment rescues endocrine, inflammatory, and transcriptional deregulation in the adult rat female offspring from gestational chronodisruption" @default.
• W4309697728 cites W1554079895 @default.
• W4309697728 cites W1884935709 @default.
• W4309697728 cites W1965304139 @default.
• W4309697728 cites W1966954824 @default.
• W4309697728 cites W1970062746 @default.
• W4309697728 cites W1973909420 @default.
• W4309697728 cites W1974960190 @default.
• W4309697728 cites W1982863473 @default.
• W4309697728 cites W1983973828 @default.
• W4309697728 cites W1985843653 @default.
• W4309697728 cites W1987171082 @default.
• W4309697728 cites W1990662781 @default.
• W4309697728 cites W2003458674 @default.
• W4309697728 cites W2003702559 @default.
• W4309697728 cites W2009479213 @default.
• W4309697728 cites W2017344107 @default.
• W4309697728 cites W2062286859 @default.
• W4309697728 cites W2073151950 @default.
• W4309697728 cites W2075657917 @default.
• W4309697728 cites W2079394987 @default.
• W4309697728 cites W2092406748 @default.
• W4309697728 cites W2116214322 @default.
• W4309697728 cites W2124550061 @default.
• W4309697728 cites W2133425478 @default.
• W4309697728 cites W2135819461 @default.
• W4309697728 cites W2157611470 @default.
• W4309697728 cites W2160945331 @default.
• W4309697728 cites W2162878054 @default.
• W4309697728 cites W2168035958 @default.
• W4309697728 cites W2169935996 @default.
• W4309697728 cites W2201789641 @default.
• W4309697728 cites W2546860066 @default.
• W4309697728 cites W2588084912 @default.
• W4309697728 cites W2588433543 @default.
• W4309697728 cites W2611050635 @default.
• W4309697728 cites W2612301460 @default.
• W4309697728 cites W2621586893 @default.
• W4309697728 cites W2737780923 @default.
• W4309697728 cites W2750800356 @default.
• W4309697728 cites W2751315423 @default.
• W4309697728 cites W2754433702 @default.
• W4309697728 cites W2788136668 @default.
• W4309697728 cites W2803464764 @default.
• W4309697728 cites W2889020112 @default.
• W4309697728 cites W2892098973 @default.
• W4309697728 cites W2895739947 @default.
• W4309697728 cites W2917177171 @default.
• W4309697728 cites W2922219401 @default.
• W4309697728 cites W2940226152 @default.
• W4309697728 cites W2953495471 @default.
• W4309697728 cites W2970402804 @default.
• W4309697728 cites W2977623584 @default.
• W4309697728 cites W2982058388 @default.
• W4309697728 cites W2984342284 @default.
• W4309697728 cites W2989834267 @default.
• W4309697728 cites W3012790961 @default.
• W4309697728 cites W3016520871 @default.
• W4309697728 cites W3024789729 @default.
• W4309697728 cites W3026166554 @default.
• W4309697728 cites W3033000669 @default.
• W4309697728 cites W3058036789 @default.
• W4309697728 cites W3089912312 @default.
• W4309697728 cites W3119824083 @default.
• W4309697728 cites W3144975504 @default.
• W4309697728 cites W3188178914 @default.
• W4309697728 cites W3189296672 @default.
• W4309697728 cites W3195012800 @default.
• W4309697728 doi "https://doi.org/10.3389/fnins.2022.1039977" @default.
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• W4309697728 hasPublicationYear "2022" @default.
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