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- W4309698249 abstract "Following the Second Summit on Human Gene Editing in Hong Kong in 2018, where the birth of two girls with germline genome editing was revealed, the need for a responsible pathway to the clinical application of human germline genome editing has been repeatedly emphasised. This paper aims to contribute to the ongoing discussion on research ethics issues in germline genome editing by exploring key issues related to the initial applications of CRISPR in reproductive medicine. Following an overview of the current discussion on bringing germline genome editing into clinical practice, we outline the specific challenges associated with such interventions and the features that distinguish them from conventional clinical testing of new medical treatments. We then review proposed ethical requirements for initial heritable genome editing, such as the absence of reasonable alternatives, the existence of sufficient and reliable preclinical data, appropriate informed consent, requirements related to safety, and long-term follow-up." @default.
- W4309698249 created "2022-11-29" @default.
- W4309698249 creator A5024858656 @default.
- W4309698249 creator A5028211971 @default.
- W4309698249 creator A5051533802 @default.
- W4309698249 date "2022-11-22" @default.
- W4309698249 modified "2023-09-26" @default.
- W4309698249 title "Initial heritable genome editing: mapping a responsible pathway from basic research to the clinic" @default.
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- W4309698249 doi "https://doi.org/10.1007/s11019-022-10115-x" @default.
- W4309698249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36414813" @default.
- W4309698249 hasPublicationYear "2022" @default.