Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309698906> ?p ?o ?g. }
- W4309698906 abstract "Severe acute and chronic graft versus host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. Historically, cord blood and matched sibling transplantation has been associated with the lowest rates of GVHD. Newer methods have modified the lymphocyte components to minimize alloimmunity, including: anti-thymocyte globulin, post-transplant cyclophosphamide, alpha/beta T cell depletion, and abatacept. These agents have shown promise in reducing severe GVHD, however, can be associated with increased risks of relapse, graft failure, infections, and delayed immune reconstitution. Nonetheless, these GVHD prophylaxis strategies have permitted expansion of donor sources, especially critical for those of non-Caucasian decent who previously lacked transplant options. This review will focus on the biologic mechanisms driving GVHD, the method by which each agent impacts these activated pathways, and the clinical consequences of these modern prophylaxis approaches. In addition, emerging novel targeted strategies will be described. These GVHD prophylaxis approaches have revolutionized our ability to increase access to transplant and have provided important insights into the biology of GVHD and immune reconstitution." @default.
- W4309698906 created "2022-11-29" @default.
- W4309698906 creator A5003061271 @default.
- W4309698906 creator A5036788225 @default.
- W4309698906 date "2022-11-23" @default.
- W4309698906 modified "2023-09-30" @default.
- W4309698906 title "Controversies and expectations for the prevention of GVHD: A biological and clinical perspective" @default.
- W4309698906 cites W1274344746 @default.
- W4309698906 cites W1444277189 @default.
- W4309698906 cites W1555868151 @default.
- W4309698906 cites W1603504083 @default.
- W4309698906 cites W1795844187 @default.
- W4309698906 cites W1965249571 @default.
- W4309698906 cites W1970070684 @default.
- W4309698906 cites W1971059638 @default.
- W4309698906 cites W1974981956 @default.
- W4309698906 cites W1975370283 @default.
- W4309698906 cites W1976959601 @default.
- W4309698906 cites W1980288572 @default.
- W4309698906 cites W1980914191 @default.
- W4309698906 cites W1988718803 @default.
- W4309698906 cites W1993798847 @default.
- W4309698906 cites W1993860179 @default.
- W4309698906 cites W1995326684 @default.
- W4309698906 cites W1996852376 @default.
- W4309698906 cites W1997563789 @default.
- W4309698906 cites W2001175629 @default.
- W4309698906 cites W2001322181 @default.
- W4309698906 cites W2004237567 @default.
- W4309698906 cites W2008138572 @default.
- W4309698906 cites W2010732369 @default.
- W4309698906 cites W2010832266 @default.
- W4309698906 cites W2011605963 @default.
- W4309698906 cites W2014400250 @default.
- W4309698906 cites W2017467835 @default.
- W4309698906 cites W2019068469 @default.
- W4309698906 cites W2023528665 @default.
- W4309698906 cites W2028795322 @default.
- W4309698906 cites W2033205664 @default.
- W4309698906 cites W2033477706 @default.
- W4309698906 cites W2036032096 @default.
- W4309698906 cites W2036749000 @default.
- W4309698906 cites W2036872637 @default.
- W4309698906 cites W2039334806 @default.
- W4309698906 cites W2041355950 @default.
- W4309698906 cites W2042030389 @default.
- W4309698906 cites W2042513876 @default.
- W4309698906 cites W2043896629 @default.
- W4309698906 cites W2044560944 @default.
- W4309698906 cites W2053653773 @default.
- W4309698906 cites W2054710330 @default.
- W4309698906 cites W2055808408 @default.
- W4309698906 cites W2059249274 @default.
- W4309698906 cites W2060741445 @default.
- W4309698906 cites W2060947850 @default.
- W4309698906 cites W2061800382 @default.
- W4309698906 cites W2066886754 @default.
- W4309698906 cites W2068021983 @default.
- W4309698906 cites W2068699102 @default.
- W4309698906 cites W2069209063 @default.
- W4309698906 cites W2070414796 @default.
- W4309698906 cites W2071416131 @default.
- W4309698906 cites W2071812113 @default.
- W4309698906 cites W2078346968 @default.
- W4309698906 cites W2079023050 @default.
- W4309698906 cites W2089818775 @default.
- W4309698906 cites W2091305961 @default.
- W4309698906 cites W2093964518 @default.
- W4309698906 cites W2097157063 @default.
- W4309698906 cites W2100088787 @default.
- W4309698906 cites W2100412095 @default.
- W4309698906 cites W2106781384 @default.
- W4309698906 cites W2110255986 @default.
- W4309698906 cites W2110475255 @default.
- W4309698906 cites W2111276737 @default.
- W4309698906 cites W2117206796 @default.
- W4309698906 cites W2122385038 @default.
- W4309698906 cites W2126021331 @default.
- W4309698906 cites W2126128896 @default.
- W4309698906 cites W2130663466 @default.
- W4309698906 cites W2134219545 @default.
- W4309698906 cites W2145860233 @default.
- W4309698906 cites W2148233118 @default.
- W4309698906 cites W2159433435 @default.
- W4309698906 cites W2167372595 @default.
- W4309698906 cites W2168717833 @default.
- W4309698906 cites W2169530433 @default.
- W4309698906 cites W2170923796 @default.
- W4309698906 cites W2209448786 @default.
- W4309698906 cites W2233354089 @default.
- W4309698906 cites W2234309584 @default.
- W4309698906 cites W2296735127 @default.
- W4309698906 cites W2325022056 @default.
- W4309698906 cites W2331997915 @default.
- W4309698906 cites W2333162405 @default.
- W4309698906 cites W2336455608 @default.
- W4309698906 cites W2337931770 @default.
- W4309698906 cites W2394869820 @default.
- W4309698906 cites W2413651842 @default.
- W4309698906 cites W2474261728 @default.