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- W4309711816 abstract "Melanoma is the most common and serious malignant tumor among skin cancers. Although more and more studies have revolutionized the systematic treatment of advanced melanoma in recent years, access to innovative drugs for melanoma is still greatly restricted in many countries. IL-12 produced mainly by antigen-presenting cells regulates the immune response and affects the differentiation of T cells in the process of antigen presentation. However, the dose-limited toxicity of IL-12 limits its clinical application. The present review summarizes the basic biological functions and toxicity of IL-12 in the treatment of melanoma and discusses the clinical application of IL-12, especially the combination of IL-12 with immune checkpoint inhibitors, cytokines and other therapeutic drugs. We also summarize several promising technological approaches such as carriers that have been developed to improve the pharmacokinetics, efficacy and safety of IL-12 or IL-12 encoding plasmid application." @default.
- W4309711816 created "2022-11-29" @default.
- W4309711816 creator A5002032950 @default.
- W4309711816 creator A5007959136 @default.
- W4309711816 creator A5072342542 @default.
- W4309711816 date "2022-11-14" @default.
- W4309711816 modified "2023-10-17" @default.
- W4309711816 title "Antitumor Activities of Interleukin-12 in Melanoma" @default.
- W4309711816 cites W1500356886 @default.
- W4309711816 cites W1561485846 @default.
- W4309711816 cites W1755989131 @default.
- W4309711816 cites W1975109271 @default.
- W4309711816 cites W1976299217 @default.
- W4309711816 cites W2003371146 @default.
- W4309711816 cites W2006741811 @default.
- W4309711816 cites W2009043731 @default.
- W4309711816 cites W2009219530 @default.
- W4309711816 cites W2015703293 @default.
- W4309711816 cites W2024089785 @default.
- W4309711816 cites W2025459290 @default.
- W4309711816 cites W2071966111 @default.
- W4309711816 cites W2073783938 @default.
- W4309711816 cites W2074348188 @default.
- W4309711816 cites W2081527131 @default.
- W4309711816 cites W2082554712 @default.
- W4309711816 cites W2089223388 @default.
- W4309711816 cites W2090639530 @default.
- W4309711816 cites W2090831287 @default.
- W4309711816 cites W2093442991 @default.
- W4309711816 cites W2100510996 @default.
- W4309711816 cites W2109616567 @default.
- W4309711816 cites W2116089582 @default.
- W4309711816 cites W2120813964 @default.
- W4309711816 cites W2134756173 @default.
- W4309711816 cites W2150145041 @default.
- W4309711816 cites W2158224546 @default.
- W4309711816 cites W2179115666 @default.
- W4309711816 cites W2209893089 @default.
- W4309711816 cites W2347055022 @default.
- W4309711816 cites W2404515555 @default.
- W4309711816 cites W2415998022 @default.
- W4309711816 cites W2463120259 @default.
- W4309711816 cites W2510628170 @default.
- W4309711816 cites W2546927172 @default.
- W4309711816 cites W2559957079 @default.
- W4309711816 cites W2594586327 @default.
- W4309711816 cites W2606495925 @default.
- W4309711816 cites W2606506416 @default.
- W4309711816 cites W2611489266 @default.
- W4309711816 cites W2751194532 @default.
- W4309711816 cites W2766938216 @default.
- W4309711816 cites W2793142165 @default.
- W4309711816 cites W2793221955 @default.
- W4309711816 cites W2794250478 @default.
- W4309711816 cites W2805421814 @default.
- W4309711816 cites W2900954772 @default.
- W4309711816 cites W2904909560 @default.
- W4309711816 cites W2946500777 @default.
- W4309711816 cites W2947977483 @default.
- W4309711816 cites W2954927939 @default.
- W4309711816 cites W2995500002 @default.
- W4309711816 cites W2996282268 @default.
- W4309711816 cites W2997901161 @default.
- W4309711816 cites W3003520466 @default.
- W4309711816 cites W3004563347 @default.
- W4309711816 cites W3010464858 @default.
- W4309711816 cites W3016092372 @default.
- W4309711816 cites W3023565412 @default.
- W4309711816 cites W3046798806 @default.
- W4309711816 cites W3059021172 @default.
- W4309711816 cites W3097520735 @default.
- W4309711816 cites W3106005610 @default.
- W4309711816 cites W3109187365 @default.
- W4309711816 cites W3128471019 @default.
- W4309711816 cites W3131994556 @default.
- W4309711816 cites W3133025128 @default.
- W4309711816 cites W3135264947 @default.
- W4309711816 cites W3158241061 @default.
- W4309711816 cites W3161527971 @default.
- W4309711816 cites W3165585845 @default.
- W4309711816 cites W3166322270 @default.
- W4309711816 cites W3190984402 @default.
- W4309711816 cites W3201596046 @default.
- W4309711816 cites W3214304040 @default.
- W4309711816 cites W3214316454 @default.
- W4309711816 cites W3217106900 @default.
- W4309711816 cites W4200258848 @default.
- W4309711816 cites W4206280295 @default.
- W4309711816 cites W4220663685 @default.
- W4309711816 cites W4224037623 @default.
- W4309711816 cites W4226087030 @default.
- W4309711816 cites W4229452725 @default.
- W4309711816 cites W4236566686 @default.
- W4309711816 cites W4245231203 @default.
- W4309711816 doi "https://doi.org/10.3390/cancers14225592" @default.
- W4309711816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36428682" @default.
- W4309711816 hasPublicationYear "2022" @default.
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