FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309713079> ?p ?o ?g. }

• W4309713079 abstract "Hemophilia A is an X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice, and the development of immunoglobulins against FVIII (inhibitors) remains the major challenge in clinical management of the disease. Here, we investigated the effect of co-administration of FVIII with intravenous immunoglobulin (IVIG) on the development of inhibitors in previously untreated hemophilia A mice. A group of hemophilia A mice (C57BL/6FVIII-/-) received weekly injections of recombinant human FVIII (rFVIII) for twelve consecutive weeks while a second group received co-injections of rFVIII + IVIG. An in-house enzyme-linked immunosorbent assay (ELISA) was designed to detect antibodies to rFVIII. Every mouse in the first group developed antibodies to rFVIII. In contrast, mice treated with rFVIII + IVIG showed significantly lower antibody titers. Interestingly, when co-administration of IVIG was discontinued after 12 weeks in some mice (rFVIII continued), these mice experienced an increase in antibody titer. In contrast, mice that continued to receive rFVIII + IVIG retained significantly lower titers. In conclusion, prophylactic rFVIII co-administration with IVIG modulated the immune response to FVIII and resulted in decreased anti-FVIII antibody titer. These findings suggest that co-injection therapy with IVIG could potentially be effective in the management of hemophilia A patients at risk of inhibitor development." @default.
• W4309713079 created "2022-11-29" @default.
• W4309713079 creator A5011451693 @default.
• W4309713079 creator A5049209739 @default.
• W4309713079 creator A5052615178 @default.
• W4309713079 creator A5054754431 @default.
• W4309713079 creator A5055696031 @default.
• W4309713079 creator A5076794588 @default.
• W4309713079 creator A5083740122 @default.
• W4309713079 date "2022-11-22" @default.
• W4309713079 modified "2023-09-30" @default.
• W4309713079 title "Co-administration of FVIII with IVIG reduces immune response to FVIII in hemophilia A mice" @default.
• W4309713079 cites W1568084954 @default.
• W4309713079 cites W1586003096 @default.
• W4309713079 cites W1816484928 @default.
• W4309713079 cites W1870763707 @default.
• W4309713079 cites W1966038367 @default.
• W4309713079 cites W1971160711 @default.
• W4309713079 cites W1980979476 @default.
• W4309713079 cites W1982034991 @default.
• W4309713079 cites W1993002849 @default.
• W4309713079 cites W1993159801 @default.
• W4309713079 cites W2004028083 @default.
• W4309713079 cites W2010725648 @default.
• W4309713079 cites W2028137697 @default.
• W4309713079 cites W2031882870 @default.
• W4309713079 cites W2046053621 @default.
• W4309713079 cites W2050130951 @default.
• W4309713079 cites W2052895859 @default.
• W4309713079 cites W2056974529 @default.
• W4309713079 cites W2067687662 @default.
• W4309713079 cites W2067865546 @default.
• W4309713079 cites W2081187509 @default.
• W4309713079 cites W2086676349 @default.
• W4309713079 cites W2087685677 @default.
• W4309713079 cites W2092412656 @default.
• W4309713079 cites W2094655231 @default.
• W4309713079 cites W2099872624 @default.
• W4309713079 cites W2116168381 @default.
• W4309713079 cites W2129481996 @default.
• W4309713079 cites W2145213708 @default.
• W4309713079 cites W2149564822 @default.
• W4309713079 cites W2150217442 @default.
• W4309713079 cites W2150585340 @default.
• W4309713079 cites W2153389047 @default.
• W4309713079 cites W2165658843 @default.
• W4309713079 cites W2274569134 @default.
• W4309713079 cites W2319468786 @default.
• W4309713079 cites W2326857555 @default.
• W4309713079 cites W2472337076 @default.
• W4309713079 cites W2569946296 @default.
• W4309713079 cites W2616639792 @default.
• W4309713079 cites W2734287351 @default.
• W4309713079 cites W2752104921 @default.
• W4309713079 cites W2761090763 @default.
• W4309713079 cites W2935499421 @default.
• W4309713079 cites W2944993744 @default.
• W4309713079 cites W4206411476 @default.
• W4309713079 cites W4211138062 @default.
• W4309713079 doi "https://doi.org/10.1038/s41598-022-19392-1" @default.
• W4309713079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36418333" @default.
• W4309713079 hasPublicationYear "2022" @default.
• W4309713079 type Work @default.
• W4309713079 citedByCount "0" @default.
• W4309713079 crossrefType "journal-article" @default.
• W4309713079 hasAuthorship W4309713079A5011451693 @default.
• W4309713079 hasAuthorship W4309713079A5049209739 @default.
• W4309713079 hasAuthorship W4309713079A5052615178 @default.
• W4309713079 hasAuthorship W4309713079A5054754431 @default.
• W4309713079 hasAuthorship W4309713079A5055696031 @default.
• W4309713079 hasAuthorship W4309713079A5076794588 @default.
• W4309713079 hasAuthorship W4309713079A5083740122 @default.
• W4309713079 hasBestOaLocation W43097130791 @default.
• W4309713079 hasConcept C104317684 @default.
• W4309713079 hasConcept C126322002 @default.
• W4309713079 hasConcept C159654299 @default.
• W4309713079 hasConcept C203014093 @default.
• W4309713079 hasConcept C22889606 @default.
• W4309713079 hasConcept C3018913218 @default.
• W4309713079 hasConcept C32611913 @default.
• W4309713079 hasConcept C40767141 @default.
• W4309713079 hasConcept C55493867 @default.
• W4309713079 hasConcept C71924100 @default.
• W4309713079 hasConcept C85663871 @default.
• W4309713079 hasConcept C86803240 @default.
• W4309713079 hasConcept C8891405 @default.
• W4309713079 hasConcept C98274493 @default.
• W4309713079 hasConceptScore W4309713079C104317684 @default.
• W4309713079 hasConceptScore W4309713079C126322002 @default.
• W4309713079 hasConceptScore W4309713079C159654299 @default.
• W4309713079 hasConceptScore W4309713079C203014093 @default.
• W4309713079 hasConceptScore W4309713079C22889606 @default.
• W4309713079 hasConceptScore W4309713079C3018913218 @default.
• W4309713079 hasConceptScore W4309713079C32611913 @default.
• W4309713079 hasConceptScore W4309713079C40767141 @default.
• W4309713079 hasConceptScore W4309713079C55493867 @default.
• W4309713079 hasConceptScore W4309713079C71924100 @default.
• W4309713079 hasConceptScore W4309713079C85663871 @default.
• W4309713079 hasConceptScore W4309713079C86803240 @default.
• W4309713079 hasConceptScore W4309713079C8891405 @default.

• next