Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309717870> ?p ?o ?g. }
- W4309717870 endingPage "14465" @default.
- W4309717870 startingPage "14465" @default.
- W4309717870 abstract "Polybrominated diphenyl ethers (PBDEs) are persistent organic chemicals implied as flame retardants. Humans are mainly exposed to BDE-47, -99, and -209 congeners by diet. PBDEs are metabolic disruptors with the liver as the main target organ. To investigate their mode of action at a human-relevant concentration, we exposed HepG2 cells to these congeners and their mixture at 1 nM, analyzing their transcriptomic and proteomic profiles. KEGG pathways and GSEA Hallmarks enrichment analyses evidenced that BDE-47 disrupted the glucose metabolism and hypoxia pathway; all the congeners and the MIX affected lipid metabolism and signaling Hallmarks regulating metabolism as mTORC1 and PI3K/AKT/MTOR. These results were confirmed by glucose secretion depletion and increased lipid accumulation, especially in BDE-47 and -209 treated cells. These congeners also affected the EGFR/MAPK signaling; further, BDE-47 enriched the estrogen pathway. Interestingly, BDE-209 and the MIX increased ERα gene expression, whereas all the congeners and the MIX induced ERβ and PPARα. We also found that PBDEs modulated several lncRNAs and that HNRNAP1 represented a central hub in all the four interaction networks. Overall, the PBDEs investigated affected glucose and lipid metabolism with different underlying modes of action, as highlighted by the integrated omics analysis, at a dietary relevant concentration. These results may support the mechanism-based risk assessment of these compounds in relation to liver metabolism disruption." @default.
- W4309717870 created "2022-11-29" @default.
- W4309717870 creator A5017143275 @default.
- W4309717870 creator A5021120994 @default.
- W4309717870 creator A5032606033 @default.
- W4309717870 creator A5049238364 @default.
- W4309717870 creator A5063868414 @default.
- W4309717870 date "2022-11-21" @default.
- W4309717870 modified "2023-10-18" @default.
- W4309717870 title "BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis" @default.
- W4309717870 cites W1499466382 @default.
- W4309717870 cites W1549595167 @default.
- W4309717870 cites W1883584254 @default.
- W4309717870 cites W1901793168 @default.
- W4309717870 cites W1968156993 @default.
- W4309717870 cites W1980550534 @default.
- W4309717870 cites W1983491513 @default.
- W4309717870 cites W1991561031 @default.
- W4309717870 cites W2039521726 @default.
- W4309717870 cites W2041295749 @default.
- W4309717870 cites W2045949302 @default.
- W4309717870 cites W2063670062 @default.
- W4309717870 cites W2077421274 @default.
- W4309717870 cites W2078594804 @default.
- W4309717870 cites W2080127092 @default.
- W4309717870 cites W2084519280 @default.
- W4309717870 cites W2091437304 @default.
- W4309717870 cites W2098628437 @default.
- W4309717870 cites W2100492886 @default.
- W4309717870 cites W2114104545 @default.
- W4309717870 cites W2116178342 @default.
- W4309717870 cites W2116764114 @default.
- W4309717870 cites W2117977572 @default.
- W4309717870 cites W2132024398 @default.
- W4309717870 cites W2144656637 @default.
- W4309717870 cites W2145635871 @default.
- W4309717870 cites W2159675211 @default.
- W4309717870 cites W2161770087 @default.
- W4309717870 cites W2169589032 @default.
- W4309717870 cites W2198153867 @default.
- W4309717870 cites W2264544500 @default.
- W4309717870 cites W2302285932 @default.
- W4309717870 cites W2407632835 @default.
- W4309717870 cites W2410865989 @default.
- W4309717870 cites W2420632344 @default.
- W4309717870 cites W2534819383 @default.
- W4309717870 cites W2596220853 @default.
- W4309717870 cites W2601826006 @default.
- W4309717870 cites W2738688133 @default.
- W4309717870 cites W2738744324 @default.
- W4309717870 cites W2751870801 @default.
- W4309717870 cites W2767336741 @default.
- W4309717870 cites W2787895864 @default.
- W4309717870 cites W2803179488 @default.
- W4309717870 cites W2884486379 @default.
- W4309717870 cites W2889283221 @default.
- W4309717870 cites W2889675607 @default.
- W4309717870 cites W2902151049 @default.
- W4309717870 cites W2914321491 @default.
- W4309717870 cites W2915075022 @default.
- W4309717870 cites W2916375280 @default.
- W4309717870 cites W2918274969 @default.
- W4309717870 cites W2947924979 @default.
- W4309717870 cites W2951766797 @default.
- W4309717870 cites W2970515629 @default.
- W4309717870 cites W2971246387 @default.
- W4309717870 cites W2978689227 @default.
- W4309717870 cites W2989046486 @default.
- W4309717870 cites W2997764977 @default.
- W4309717870 cites W3000568989 @default.
- W4309717870 cites W3008861511 @default.
- W4309717870 cites W3008893235 @default.
- W4309717870 cites W3014299867 @default.
- W4309717870 cites W3026956956 @default.
- W4309717870 cites W3093278688 @default.
- W4309717870 cites W3096145675 @default.
- W4309717870 cites W3108874111 @default.
- W4309717870 cites W3109159825 @default.
- W4309717870 cites W3117948483 @default.
- W4309717870 cites W3119481659 @default.
- W4309717870 cites W3167591013 @default.
- W4309717870 cites W3191200190 @default.
- W4309717870 cites W3198591104 @default.
- W4309717870 cites W3199110160 @default.
- W4309717870 cites W3202059766 @default.
- W4309717870 cites W4210289220 @default.
- W4309717870 cites W4211132165 @default.
- W4309717870 doi "https://doi.org/10.3390/ijms232214465" @default.
- W4309717870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36430946" @default.
- W4309717870 hasPublicationYear "2022" @default.
- W4309717870 type Work @default.
- W4309717870 citedByCount "1" @default.
- W4309717870 countsByYear W43097178702023 @default.
- W4309717870 crossrefType "journal-article" @default.
- W4309717870 hasAuthorship W4309717870A5017143275 @default.
- W4309717870 hasAuthorship W4309717870A5021120994 @default.
- W4309717870 hasAuthorship W4309717870A5032606033 @default.
- W4309717870 hasAuthorship W4309717870A5049238364 @default.