FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309718296> ?p ?o ?g. }

• W4309718296 endingPage "8095" @default.
• W4309718296 startingPage "8095" @default.
• W4309718296 abstract "Diabetes, a prevalent metabolic condition with a wide range of complications, is fast becoming a global health crisis. Herbal medicine and enhanced extracts are some of the therapeutic options used in the management of diabetes mellitus. The plant-derived molecules and their suitable structure modification have given many leads or drugs to the world such as metformin used as an antidiabetic drug. The stem extract of Sclerocarya birrea has been reported as a potent antidiabetic (glucose uptake) agent. However, the bioactive compounds have not been reported from S. birrea for treatment of diabetes. In this study, the spray-dried aqueous leaf extracts of S. birrea were investigated as an antidiabetic agent using a 2-deoxy-glucose (2DG) technique showing good stimulatory effect on glucose uptake in differentiated C2C12 myocytes with % 2DG uptake ranging from 110-180% that was comparable to the positive control insulin. Three compounds were isolated and identified using bioassay-guided fractionation of the spray-dried aqueous extract of S. birrea leaves: myricetin (1), myricetin-3-O-β-D-glucuronide (2) and quercetin-3-O-β-D-glucuronide (3). Their chemical structures were determined using NMR and mass spectrometric analyses, as well as a comparison of experimentally obtained data to those reported in the literature. The isolated compounds (1-3) were studied for their stimulatory actions on glucose uptake in differentiated C2C12 myocytes. The three compounds (1, 2 and 3) showed stimulatory effects on the uptake of 2DG in C2C12 myocytes with % 2DG uptake ranging from 43.9-109.1% that was better compared to the positive control insulin. Additionally, this is the first report of the flavonoid glycosides (myricetin-3-O-β-D-glucuronide) for antidiabetic activity and they are the main bioactive compound in the extract responsible for the antidiabetic activity. This result suggests that the S. birrea leaves have the potential to be developed for treatment of diabetes." @default.
• W4309718296 created "2022-11-29" @default.
• W4309718296 creator A5006611112 @default.
• W4309718296 creator A5006765823 @default.
• W4309718296 creator A5013113551 @default.
• W4309718296 creator A5023584525 @default.
• W4309718296 creator A5039869724 @default.
• W4309718296 date "2022-11-21" @default.
• W4309718296 modified "2023-10-16" @default.
• W4309718296 title "Identification of Antidiabetic Compounds from the Aqueous Extract of Sclerocarya birrea Leaves" @default.
• W4309718296 cites W115848702 @default.
• W4309718296 cites W1975223160 @default.
• W4309718296 cites W1993318456 @default.
• W4309718296 cites W2001881599 @default.
• W4309718296 cites W2002691923 @default.
• W4309718296 cites W2040789867 @default.
• W4309718296 cites W2048557976 @default.
• W4309718296 cites W2059311791 @default.
• W4309718296 cites W2072105294 @default.
• W4309718296 cites W2103214429 @default.
• W4309718296 cites W2114918609 @default.
• W4309718296 cites W2119803202 @default.
• W4309718296 cites W2142405801 @default.
• W4309718296 cites W2149322480 @default.
• W4309718296 cites W2157304833 @default.
• W4309718296 cites W2164642636 @default.
• W4309718296 cites W2254168655 @default.
• W4309718296 cites W2292936772 @default.
• W4309718296 cites W2299857967 @default.
• W4309718296 cites W2578656048 @default.
• W4309718296 cites W2728621008 @default.
• W4309718296 cites W2735943888 @default.
• W4309718296 cites W2884202462 @default.
• W4309718296 cites W2886186722 @default.
• W4309718296 cites W2888538492 @default.
• W4309718296 cites W2888814360 @default.
• W4309718296 cites W2901187797 @default.
• W4309718296 cites W2901252003 @default.
• W4309718296 cites W2901273331 @default.
• W4309718296 cites W2909848347 @default.
• W4309718296 cites W2919472220 @default.
• W4309718296 cites W2926830849 @default.
• W4309718296 cites W2955990239 @default.
• W4309718296 cites W2964989731 @default.
• W4309718296 cites W2980639864 @default.
• W4309718296 cites W2999318444 @default.
• W4309718296 cites W3014010933 @default.
• W4309718296 cites W3042750145 @default.
• W4309718296 cites W3080135308 @default.
• W4309718296 cites W3093469110 @default.
• W4309718296 cites W3123002967 @default.
• W4309718296 cites W3177909977 @default.
• W4309718296 cites W3185702348 @default.
• W4309718296 cites W3196213304 @default.
• W4309718296 cites W4221105402 @default.
• W4309718296 doi "https://doi.org/10.3390/molecules27228095" @default.
• W4309718296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36432195" @default.
• W4309718296 hasPublicationYear "2022" @default.
• W4309718296 type Work @default.
• W4309718296 citedByCount "0" @default.
• W4309718296 crossrefType "journal-article" @default.
• W4309718296 hasAuthorship W4309718296A5006611112 @default.
• W4309718296 hasAuthorship W4309718296A5006765823 @default.
• W4309718296 hasAuthorship W4309718296A5013113551 @default.
• W4309718296 hasAuthorship W4309718296A5023584525 @default.
• W4309718296 hasAuthorship W4309718296A5039869724 @default.
• W4309718296 hasBestOaLocation W43097182961 @default.
• W4309718296 hasConcept C126322002 @default.
• W4309718296 hasConcept C134018914 @default.
• W4309718296 hasConcept C185592680 @default.
• W4309718296 hasConcept C2777810353 @default.
• W4309718296 hasConcept C2777866211 @default.
• W4309718296 hasConcept C2778004101 @default.
• W4309718296 hasConcept C2778173338 @default.
• W4309718296 hasConcept C2779306644 @default.
• W4309718296 hasConcept C2781263971 @default.
• W4309718296 hasConcept C55493867 @default.
• W4309718296 hasConcept C555293320 @default.
• W4309718296 hasConcept C556039675 @default.
• W4309718296 hasConcept C71924100 @default.
• W4309718296 hasConcept C98274493 @default.
• W4309718296 hasConceptScore W4309718296C126322002 @default.
• W4309718296 hasConceptScore W4309718296C134018914 @default.
• W4309718296 hasConceptScore W4309718296C185592680 @default.
• W4309718296 hasConceptScore W4309718296C2777810353 @default.
• W4309718296 hasConceptScore W4309718296C2777866211 @default.
• W4309718296 hasConceptScore W4309718296C2778004101 @default.
• W4309718296 hasConceptScore W4309718296C2778173338 @default.
• W4309718296 hasConceptScore W4309718296C2779306644 @default.
• W4309718296 hasConceptScore W4309718296C2781263971 @default.
• W4309718296 hasConceptScore W4309718296C55493867 @default.
• W4309718296 hasConceptScore W4309718296C555293320 @default.
• W4309718296 hasConceptScore W4309718296C556039675 @default.
• W4309718296 hasConceptScore W4309718296C71924100 @default.
• W4309718296 hasConceptScore W4309718296C98274493 @default.
• W4309718296 hasIssue "22" @default.
• W4309718296 hasLocation W43097182961 @default.
• W4309718296 hasLocation W43097182962 @default.

• next