FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309718537> ?p ?o ?g. }

• W4309718537 endingPage "3645" @default.
• W4309718537 startingPage "3645" @default.
• W4309718537 abstract "Despite the medico-surgical progress that has been made in the management of patients with colorectal cancer (CRC), the prognosis at five years remains poor. This resistance of cancer cells partly results from their phenotypic characteristics in connection with the epithelial-mesenchymal transition (EMT). In the present study, we have explored the ability of a polyphenol, tannic acid (TA), to counteract CRC cell proliferation and invasion through an action on the EMT. We highlight that TA decreases human SW480 and SW620 CRC cell and murine CT26 CRC cell viability, and TA inhibits their adhesion in the presence of important factors comprising the extracellular matrix, particularly in the presence of collagen type I and IV, and fibronectin. Moreover, these properties were associated with TA's ability to disrupt CRC cell migration and invasion, which are induced by transforming growth factor-β (TGF-β), as evidence in the video microscopy experiments showing that TA blocks the TGF-β1-induced migration of SW480 and CT26 cells. At the molecular level, TA promotes a reversal of the epithelial-mesenchymal transition by repressing the mesenchymal markers (i.e., Slug, Snail, ZEB1, and N-cadherin) and re-expressing the epithelial markers (i.e., E-cadherin and β-catenin). These effects could result from a disruption of the non-canonical signaling pathway that is induced by TGF-β1, where TA strongly decreases the phosphorylation of extracellular-signal regulated kinase ERK1/2, P38 and the AKT proteins that are well known to contribute to the EMT, the cell motility, and the acquisition of invasive properties by tumor cells. Very interestingly, a preclinical study of mice with subcutaneous murine tumor colon CT26 cells has shown that TA was able to significantly delay the growth of tumors without hepato- and nephrotoxicities." @default.
• W4309718537 created "2022-11-29" @default.
• W4309718537 creator A5000395347 @default.
• W4309718537 creator A5025991443 @default.
• W4309718537 creator A5027979637 @default.
• W4309718537 creator A5039436465 @default.
• W4309718537 creator A5050830295 @default.
• W4309718537 creator A5051412023 @default.
• W4309718537 creator A5059372884 @default.
• W4309718537 creator A5065446278 @default.
• W4309718537 creator A5073249471 @default.
• W4309718537 date "2022-11-17" @default.
• W4309718537 modified "2023-10-18" @default.
• W4309718537 title "Tannic Acid, A Hydrolysable Tannin, Prevents Transforming Growth Factor-β-Induced Epithelial–Mesenchymal Transition to Counteract Colorectal Tumor Growth" @default.
• W4309718537 cites W1565561072 @default.
• W4309718537 cites W1766690133 @default.
• W4309718537 cites W1806683388 @default.
• W4309718537 cites W1964847767 @default.
• W4309718537 cites W1973064781 @default.
• W4309718537 cites W1973892250 @default.
• W4309718537 cites W1979988883 @default.
• W4309718537 cites W1988824459 @default.
• W4309718537 cites W1994242450 @default.
• W4309718537 cites W2000154460 @default.
• W4309718537 cites W2016360721 @default.
• W4309718537 cites W2018819150 @default.
• W4309718537 cites W2024919757 @default.
• W4309718537 cites W2025647419 @default.
• W4309718537 cites W2026260372 @default.
• W4309718537 cites W2034109502 @default.
• W4309718537 cites W2035653659 @default.
• W4309718537 cites W2037583144 @default.
• W4309718537 cites W2042965279 @default.
• W4309718537 cites W2046987897 @default.
• W4309718537 cites W2075093878 @default.
• W4309718537 cites W2086692663 @default.
• W4309718537 cites W2086756946 @default.
• W4309718537 cites W2087367170 @default.
• W4309718537 cites W2097642044 @default.
• W4309718537 cites W2099384309 @default.
• W4309718537 cites W2106411439 @default.
• W4309718537 cites W2116719283 @default.
• W4309718537 cites W2132018812 @default.
• W4309718537 cites W2137280750 @default.
• W4309718537 cites W2142928449 @default.
• W4309718537 cites W2145606620 @default.
• W4309718537 cites W2156626705 @default.
• W4309718537 cites W2165901622 @default.
• W4309718537 cites W2317582029 @default.
• W4309718537 cites W2338192894 @default.
• W4309718537 cites W2463615816 @default.
• W4309718537 cites W2743491871 @default.
• W4309718537 cites W2765878450 @default.
• W4309718537 cites W2771136768 @default.
• W4309718537 cites W2790084239 @default.
• W4309718537 cites W2803823272 @default.
• W4309718537 cites W2887029183 @default.
• W4309718537 cites W2911188335 @default.
• W4309718537 cites W2941350045 @default.
• W4309718537 cites W2965216369 @default.
• W4309718537 cites W3004517392 @default.
• W4309718537 cites W3011336139 @default.
• W4309718537 cites W3012863471 @default.
• W4309718537 cites W3017767374 @default.
• W4309718537 cites W3026178022 @default.
• W4309718537 cites W3118450549 @default.
• W4309718537 cites W3133917975 @default.
• W4309718537 cites W4280556363 @default.
• W4309718537 cites W4283657619 @default.
• W4309718537 doi "https://doi.org/10.3390/cells11223645" @default.
• W4309718537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36429073" @default.
• W4309718537 hasPublicationYear "2022" @default.
• W4309718537 type Work @default.
• W4309718537 citedByCount "2" @default.
• W4309718537 countsByYear W43097185372023 @default.
• W4309718537 crossrefType "journal-article" @default.
• W4309718537 hasAuthorship W4309718537A5000395347 @default.
• W4309718537 hasAuthorship W4309718537A5025991443 @default.
• W4309718537 hasAuthorship W4309718537A5027979637 @default.
• W4309718537 hasAuthorship W4309718537A5039436465 @default.
• W4309718537 hasAuthorship W4309718537A5050830295 @default.
• W4309718537 hasAuthorship W4309718537A5051412023 @default.
• W4309718537 hasAuthorship W4309718537A5059372884 @default.
• W4309718537 hasAuthorship W4309718537A5065446278 @default.
• W4309718537 hasAuthorship W4309718537A5073249471 @default.
• W4309718537 hasBestOaLocation W43097185371 @default.
• W4309718537 hasConcept C118131993 @default.
• W4309718537 hasConcept C121608353 @default.
• W4309718537 hasConcept C137738243 @default.
• W4309718537 hasConcept C1491633281 @default.
• W4309718537 hasConcept C149402561 @default.
• W4309718537 hasConcept C185592680 @default.
• W4309718537 hasConcept C189165786 @default.
• W4309718537 hasConcept C198826908 @default.
• W4309718537 hasConcept C2779013556 @default.
• W4309718537 hasConcept C502942594 @default.
• W4309718537 hasConcept C54355233 @default.
• W4309718537 hasConcept C55493867 @default.

• next