Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309720108> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4309720108 endingPage "83" @default.
- W4309720108 startingPage "76" @default.
- W4309720108 abstract "Borderline ovarian tumors are a special class of ovarian tumors between benign and malignant, which are not sensitive to traditional chemotherapy regimens, and the development of target drugs is limited due to the lack of cell lines. Tumor organoids can well preserve the genetic characteristics of the primary tumor, but there are only a few reports of application in borderline tumors. In this study, we successfully generated 13 ovarian borderline tumor organoids and tested the antitumor activity of Bractoppin, a BRCA1 carboxy-terminal domain (BRCT) inhibitor. Bractoppin promotes organoid apoptosis. Mechanistically, Bractoppin can inhibit organoid cell cycle progression, inhibit the repair of DSB damage and promote tumor cell apoptosis. In addition, Bractoppin can also promote the apoptosis of ovarian cancer cell lines and inhibit the HR and NHEJ repair ability of tumor cells. We demonstrate the value of ovarian borderline tumor organoids in the exploration of molecular therapy drugs, and Bractoppin may be a valuable small molecule drug in the treatment of BOT." @default.
- W4309720108 created "2022-11-29" @default.
- W4309720108 creator A5021541475 @default.
- W4309720108 creator A5035998127 @default.
- W4309720108 creator A5043415973 @default.
- W4309720108 creator A5049203751 @default.
- W4309720108 creator A5067156462 @default.
- W4309720108 creator A5071931173 @default.
- W4309720108 creator A5088179022 @default.
- W4309720108 date "2023-01-01" @default.
- W4309720108 modified "2023-10-07" @default.
- W4309720108 title "Bractoppin, a BRCA1 carboxy-terminal domain (BRCT) inhibitor, suppresses tumor progression in ovarian borderline tumor organoids" @default.
- W4309720108 cites W1931471783 @default.
- W4309720108 cites W2073148121 @default.
- W4309720108 cites W2093640633 @default.
- W4309720108 cites W2109409755 @default.
- W4309720108 cites W2490467724 @default.
- W4309720108 cites W2794817016 @default.
- W4309720108 cites W2939543377 @default.
- W4309720108 cites W3002742562 @default.
- W4309720108 cites W3049256974 @default.
- W4309720108 cites W3139061246 @default.
- W4309720108 cites W3170879342 @default.
- W4309720108 cites W3184878554 @default.
- W4309720108 cites W3195557681 @default.
- W4309720108 cites W3204070988 @default.
- W4309720108 cites W4200034848 @default.
- W4309720108 cites W4206691856 @default.
- W4309720108 cites W4210762341 @default.
- W4309720108 cites W4285076881 @default.
- W4309720108 cites W4295030098 @default.
- W4309720108 cites W4295159834 @default.
- W4309720108 cites W4296161456 @default.
- W4309720108 cites W4296286093 @default.
- W4309720108 doi "https://doi.org/10.1016/j.bbrc.2022.11.063" @default.
- W4309720108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36442235" @default.
- W4309720108 hasPublicationYear "2023" @default.
- W4309720108 type Work @default.
- W4309720108 citedByCount "1" @default.
- W4309720108 countsByYear W43097201082023 @default.
- W4309720108 crossrefType "journal-article" @default.
- W4309720108 hasAuthorship W4309720108A5021541475 @default.
- W4309720108 hasAuthorship W4309720108A5035998127 @default.
- W4309720108 hasAuthorship W4309720108A5043415973 @default.
- W4309720108 hasAuthorship W4309720108A5049203751 @default.
- W4309720108 hasAuthorship W4309720108A5067156462 @default.
- W4309720108 hasAuthorship W4309720108A5071931173 @default.
- W4309720108 hasAuthorship W4309720108A5088179022 @default.
- W4309720108 hasBestOaLocation W43097201081 @default.
- W4309720108 hasConcept C121608353 @default.
- W4309720108 hasConcept C1491633281 @default.
- W4309720108 hasConcept C190283241 @default.
- W4309720108 hasConcept C2780084626 @default.
- W4309720108 hasConcept C2780427987 @default.
- W4309720108 hasConcept C31695470 @default.
- W4309720108 hasConcept C502942594 @default.
- W4309720108 hasConcept C54355233 @default.
- W4309720108 hasConcept C81885089 @default.
- W4309720108 hasConcept C86803240 @default.
- W4309720108 hasConcept C95444343 @default.
- W4309720108 hasConceptScore W4309720108C121608353 @default.
- W4309720108 hasConceptScore W4309720108C1491633281 @default.
- W4309720108 hasConceptScore W4309720108C190283241 @default.
- W4309720108 hasConceptScore W4309720108C2780084626 @default.
- W4309720108 hasConceptScore W4309720108C2780427987 @default.
- W4309720108 hasConceptScore W4309720108C31695470 @default.
- W4309720108 hasConceptScore W4309720108C502942594 @default.
- W4309720108 hasConceptScore W4309720108C54355233 @default.
- W4309720108 hasConceptScore W4309720108C81885089 @default.
- W4309720108 hasConceptScore W4309720108C86803240 @default.
- W4309720108 hasConceptScore W4309720108C95444343 @default.
- W4309720108 hasFunder F4320335443 @default.
- W4309720108 hasLocation W43097201081 @default.
- W4309720108 hasLocation W43097201082 @default.
- W4309720108 hasOpenAccess W4309720108 @default.
- W4309720108 hasPrimaryLocation W43097201081 @default.
- W4309720108 hasRelatedWork W1518035471 @default.
- W4309720108 hasRelatedWork W1975372488 @default.
- W4309720108 hasRelatedWork W2030883789 @default.
- W4309720108 hasRelatedWork W2069300823 @default.
- W4309720108 hasRelatedWork W2168388492 @default.
- W4309720108 hasRelatedWork W2370888976 @default.
- W4309720108 hasRelatedWork W2972524777 @default.
- W4309720108 hasRelatedWork W4313622594 @default.
- W4309720108 hasRelatedWork W4362545130 @default.
- W4309720108 hasRelatedWork W4362568092 @default.
- W4309720108 hasVolume "638" @default.
- W4309720108 isParatext "false" @default.
- W4309720108 isRetracted "false" @default.
- W4309720108 workType "article" @default.