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- W4309721406 endingPage "3723" @default.
- W4309721406 startingPage "3723" @default.
- W4309721406 abstract "Nucleotide excision repair (NER) is a central DNA repair pathway responsible for removing a wide variety of DNA-distorting lesions from the genome. The highly choreographed cascade of core NER reactions requires more than 30 polypeptides. The xeroderma pigmentosum group A (XPA) protein plays an essential role in the NER process. XPA interacts with almost all NER participants and organizes the correct NER repair complex. In the absence of XPA’s scaffolding function, no repair process occurs. In this review, we briefly summarize our current knowledge about the XPA protein structure and analyze the formation of contact with its protein partners during NER complex assembling. We focus on different ways of regulation of the XPA protein’s activity and expression and pay special attention to the network of post-translational modifications. We also discuss the data that is not in line with the currently accepted hypothesis about the functioning of the XPA protein." @default.
- W4309721406 created "2022-11-29" @default.
- W4309721406 creator A5001007906 @default.
- W4309721406 creator A5016778652 @default.
- W4309721406 creator A5085712207 @default.
- W4309721406 date "2022-11-22" @default.
- W4309721406 modified "2023-09-26" @default.
- W4309721406 title "The XPA Protein—Life under Precise Control" @default.
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