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- W4309728736 abstract "Comprehensive genomic profiling examinations (CGPs) have recently been developed, and a variety of tumor-agnostic mutations have been detected, leading to the development of new molecular-targetable therapies across solid tumors. In addition, the elucidation of hereditary tumors, such as breast and ovarian cancer, has pioneered a new age marked by the development of new treatments and lifetime management strategies required for patients with potential or presented hereditary cancers. In acute myeloid leukemia (AML), however, few tumor-agnostic or hereditary mutations have been the focus of investigation, with associated molecular-targeted therapies remaining poorly developed. We focused on representative tumor-agnostic mutations such as the TP53, KIT, KRAS, BRCA1, ATM, JAK2, NTRK3, FGFR3 and EGFR genes, referring to a CGP study conducted in Japan, and we considered the possibility of developing molecular-targeted therapies for AML with tumor-agnostic mutations. We summarized the frequency, the prognosis, the structure and the function of these mutations as well as the current treatment strategies in solid tumors, revealed the genetical relationships between solid tumors and AML and developed tumor-agnostic molecular-targeted therapies and lifetime management strategies in AML." @default.
- W4309728736 created "2022-11-29" @default.
- W4309728736 creator A5004170848 @default.
- W4309728736 creator A5018883124 @default.
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- W4309728736 creator A5069675532 @default.
- W4309728736 creator A5072956865 @default.
- W4309728736 creator A5089308854 @default.
- W4309728736 date "2022-11-22" @default.
- W4309728736 modified "2023-10-06" @default.
- W4309728736 title "Molecular-Targeted Therapy for Tumor-Agnostic Mutations in Acute Myeloid Leukemia" @default.
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