Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309732821> ?p ?o ?g. }
- W4309732821 abstract "Intracranial hematomas (ICH) are a frequent condition in neurosurgical and neurological practices, with several mechanisms of primary and secondary injury. Experimental research has been fundamental for the understanding of the pathophysiology implicated with ICH and the development of therapeutic interventions. To date, a variety of different animal approaches have been described that consider, for example, the ICH evolutive phase, molecular implications and hemodynamic changes. Therefore, choosing a test protocol should consider the scope of each particular study. The present review summarized investigational protocols in experimental research on the subject of ICH. With this subject, injection of autologous blood or bacterial collagenase, inflation of intracranial balloon and avulsion of cerebral vessels were the models identified. Rodents (mice) and swine were the most frequent species used. These different models allowed improvements on the understanding of intracranial hypertension establishment, neuroinflammation, immunology, brain hemodynamics and served to the development of therapeutic strategies." @default.
- W4309732821 created "2022-11-29" @default.
- W4309732821 creator A5004815769 @default.
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- W4309732821 creator A5083263956 @default.
- W4309732821 date "2022-11-22" @default.
- W4309732821 modified "2023-10-01" @default.
- W4309732821 title "Animal models for the study of intracranial hematomas (Review)" @default.
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