Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309734558> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4309734558 abstract "ABSTRACT Understanding the thermodynamics that drives liquid-liquid phase separation (LLPS) is quite important given the many numbers of diverse biomolecular systems undergoing this phenomenon. Regardless of the diversity, the processes underlying the formation of condensates exhibit physical similarities. Many studies have focused on condensates of long polymers, but very few systems of short polymer condensates have been observed and yet studied. Here we study a short polymer system of various lengths of poly-Adenine RNA and peptide formed by the RGRGG sequence repeats to understand the underlying thermodynamics of LLPS. We carried out MD simulations using the recently developed COCOMO coarse-grained (CG) model which revealed the possibility of condensates for lengths as short as 5-10 residues, which was then confirmed by experiment, making this one of the smallest LLPS systems yet observed. Condensation depends on polymer length and concentration, and phase boundaries were identified. A free energy model was also developed. Results show that the length dependent condensation is driven solely by entropy of confinement and identifies a negative free energy ( -ΔG ) of phase separation, indicating the stability of the condensates. The simplicity of this system will provide the basis for understanding more biologically realistic systems." @default.
- W4309734558 created "2022-11-29" @default.
- W4309734558 creator A5011006181 @default.
- W4309734558 creator A5039874521 @default.
- W4309734558 creator A5047133042 @default.
- W4309734558 creator A5061800523 @default.
- W4309734558 creator A5075856537 @default.
- W4309734558 creator A5082388300 @default.
- W4309734558 date "2022-11-21" @default.
- W4309734558 modified "2023-10-17" @default.
- W4309734558 title "The Effect of Polymer Length in Phase Separation" @default.
- W4309734558 cites W1938908576 @default.
- W4309734558 cites W2041278780 @default.
- W4309734558 cites W2077168920 @default.
- W4309734558 cites W2111796925 @default.
- W4309734558 cites W2117226853 @default.
- W4309734558 cites W2139066576 @default.
- W4309734558 cites W2461977200 @default.
- W4309734558 cites W2566070701 @default.
- W4309734558 cites W2590568317 @default.
- W4309734558 cites W2743471889 @default.
- W4309734558 cites W2755105920 @default.
- W4309734558 cites W2953933961 @default.
- W4309734558 cites W2969788883 @default.
- W4309734558 cites W3003547858 @default.
- W4309734558 cites W3035241254 @default.
- W4309734558 cites W3087691776 @default.
- W4309734558 cites W3093248066 @default.
- W4309734558 cites W3114906816 @default.
- W4309734558 cites W3122883665 @default.
- W4309734558 cites W3124093787 @default.
- W4309734558 cites W3126441452 @default.
- W4309734558 cites W3163603304 @default.
- W4309734558 cites W3171719575 @default.
- W4309734558 cites W3201009248 @default.
- W4309734558 cites W3212759171 @default.
- W4309734558 cites W4200346882 @default.
- W4309734558 cites W4220831698 @default.
- W4309734558 cites W4220925195 @default.
- W4309734558 cites W4220929593 @default.
- W4309734558 cites W4247272913 @default.
- W4309734558 cites W4292978476 @default.
- W4309734558 doi "https://doi.org/10.1101/2022.11.21.517354" @default.
- W4309734558 hasPublicationYear "2022" @default.
- W4309734558 type Work @default.
- W4309734558 citedByCount "0" @default.
- W4309734558 crossrefType "posted-content" @default.
- W4309734558 hasAuthorship W4309734558A5011006181 @default.
- W4309734558 hasAuthorship W4309734558A5039874521 @default.
- W4309734558 hasAuthorship W4309734558A5047133042 @default.
- W4309734558 hasAuthorship W4309734558A5061800523 @default.
- W4309734558 hasAuthorship W4309734558A5075856537 @default.
- W4309734558 hasAuthorship W4309734558A5082388300 @default.
- W4309734558 hasBestOaLocation W43097345581 @default.
- W4309734558 hasConcept C106301342 @default.
- W4309734558 hasConcept C121332964 @default.
- W4309734558 hasConcept C121864883 @default.
- W4309734558 hasConcept C159467904 @default.
- W4309734558 hasConcept C178790620 @default.
- W4309734558 hasConcept C185592680 @default.
- W4309734558 hasConcept C192562407 @default.
- W4309734558 hasConcept C200093464 @default.
- W4309734558 hasConcept C521977710 @default.
- W4309734558 hasConcept C97355855 @default.
- W4309734558 hasConceptScore W4309734558C106301342 @default.
- W4309734558 hasConceptScore W4309734558C121332964 @default.
- W4309734558 hasConceptScore W4309734558C121864883 @default.
- W4309734558 hasConceptScore W4309734558C159467904 @default.
- W4309734558 hasConceptScore W4309734558C178790620 @default.
- W4309734558 hasConceptScore W4309734558C185592680 @default.
- W4309734558 hasConceptScore W4309734558C192562407 @default.
- W4309734558 hasConceptScore W4309734558C200093464 @default.
- W4309734558 hasConceptScore W4309734558C521977710 @default.
- W4309734558 hasConceptScore W4309734558C97355855 @default.
- W4309734558 hasLocation W43097345581 @default.
- W4309734558 hasOpenAccess W4309734558 @default.
- W4309734558 hasPrimaryLocation W43097345581 @default.
- W4309734558 hasRelatedWork W2320589942 @default.
- W4309734558 hasRelatedWork W2347176820 @default.
- W4309734558 hasRelatedWork W2398328584 @default.
- W4309734558 hasRelatedWork W2402555317 @default.
- W4309734558 hasRelatedWork W2899084033 @default.
- W4309734558 hasRelatedWork W2949206020 @default.
- W4309734558 hasRelatedWork W2949985046 @default.
- W4309734558 hasRelatedWork W2951501612 @default.
- W4309734558 hasRelatedWork W2952154574 @default.
- W4309734558 hasRelatedWork W2952223385 @default.
- W4309734558 isParatext "false" @default.
- W4309734558 isRetracted "false" @default.
- W4309734558 workType "article" @default.