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- W4309744790 abstract "Inspired by the natural intercellular material-transfer process of trans-endocytosis or trogocytosis, we proposed that targeted farnesylated chemically self-assembled nanorings (f-CSANs) could serve as a biomimetic trogocytosis vehicle for engineering directional cargo transfer between cells, thus allowing cell-cell interactions to be monitored and facilitating cell-cell communications. The membranes of sender cells were stably modified by hydrophobic insertion with the targeted f-CSANs, which were efficiently transferred to receiver cells expressing the appropriate receptors by endocytosis. CSAN-assisted cell-cell cargo transfer (C4T) was demonstrated to be receptor specific and dependent on direct cell-cell interactions, the rate of receptor internalization, and the level of receptor expression. In addition, C4T was shown to facilitate cell-to-cell delivery of an apoptosis inducing drug, as wells as antisense oligonucleotides. Taken together, the C4T approach is a potentially versatile biomimetic trogocytosis platform that can be deployed as a macro-chemical biological tool for monitoring cell-cell interactions and engineering cell-cell communications." @default.
- W4309744790 created "2022-11-29" @default.
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- W4309744790 date "2022-11-23" @default.
- W4309744790 modified "2023-10-15" @default.
- W4309744790 title "Engineering Biomimetic Trogocytosis with Farnesylated Chemically Self-Assembled Nanorings" @default.
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- W4309744790 doi "https://doi.org/10.1021/acs.biomac.2c00837" @default.
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