Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309751465> ?p ?o ?g. }
- W4309751465 abstract "Abstract Neutrophils are important components of innate immunity in the blood. They are the body's first line of defense against microbial pathogens, especially when suppurative bacteria invade. Since its function can be both beneficial and harmful to the pathogen and the surrounding host tissues, its functions must be tightly regulated. First discovered in red blood cells, the 4.1R protein is a membrane skeleton protein that plays an important role in regulating the deformation and stability of the membrane. Many lines of evidence suggest that 4.1R has the ability to regulate cellular pathways in a variety of immune cells, but its function in neutrophils has not yet been reported. Here, we investigated the function of 4.1R in neutrophils using 4.1R −/− mice. Our results showed that the chemotactic function, phagocytic function, ROS production ability, and the secretion of inflammatory factors were increased in the 4.1R −/− neutrophils. Furthermore, results from in vivo experiments demonstrated that 4.1R −/− mice recruited more neutrophils, secreted higher levels of inflammatory cytokines, and had a shorter life-span. Further mechanistic evaluation revealed that the protein phosphorylation of JAK2/STAT3 was increased in the 4.1R knockout neutrophils after their stimulation and activation. In summary, the expression of 4.1R protein has an important negative regulatory effect on neutrophil function, which may be mediated through the JAK2/STAT3 signaling pathway." @default.
- W4309751465 created "2022-11-29" @default.
- W4309751465 creator A5000154613 @default.
- W4309751465 creator A5017951067 @default.
- W4309751465 creator A5021557384 @default.
- W4309751465 creator A5049132248 @default.
- W4309751465 creator A5049236401 @default.
- W4309751465 creator A5055838125 @default.
- W4309751465 creator A5065973605 @default.
- W4309751465 creator A5074221408 @default.
- W4309751465 creator A5077322975 @default.
- W4309751465 creator A5077885898 @default.
- W4309751465 creator A5079647691 @default.
- W4309751465 creator A5084619384 @default.
- W4309751465 date "2022-11-21" @default.
- W4309751465 modified "2023-09-26" @default.
- W4309751465 title "Protein 4.1R regulates neutrophil function through the JAK2/STAT3 signaling pathway" @default.
- W4309751465 cites W1501028118 @default.
- W4309751465 cites W1506049383 @default.
- W4309751465 cites W1964484264 @default.
- W4309751465 cites W1976554265 @default.
- W4309751465 cites W1988201936 @default.
- W4309751465 cites W2005705806 @default.
- W4309751465 cites W2009454655 @default.
- W4309751465 cites W2009762249 @default.
- W4309751465 cites W2013376648 @default.
- W4309751465 cites W2014626116 @default.
- W4309751465 cites W2036177806 @default.
- W4309751465 cites W2037988884 @default.
- W4309751465 cites W2043934915 @default.
- W4309751465 cites W2044904185 @default.
- W4309751465 cites W2077399951 @default.
- W4309751465 cites W2079692165 @default.
- W4309751465 cites W2084291206 @default.
- W4309751465 cites W2084956094 @default.
- W4309751465 cites W2093748429 @default.
- W4309751465 cites W2099596517 @default.
- W4309751465 cites W2113974673 @default.
- W4309751465 cites W2114570899 @default.
- W4309751465 cites W2116274871 @default.
- W4309751465 cites W2119655833 @default.
- W4309751465 cites W2127715753 @default.
- W4309751465 cites W2133787519 @default.
- W4309751465 cites W2161551858 @default.
- W4309751465 cites W2301274664 @default.
- W4309751465 cites W2397316750 @default.
- W4309751465 cites W2500759813 @default.
- W4309751465 cites W2518357142 @default.
- W4309751465 cites W2566543153 @default.
- W4309751465 cites W2914524806 @default.
- W4309751465 cites W2990337693 @default.
- W4309751465 cites W3080683959 @default.
- W4309751465 cites W3122907323 @default.
- W4309751465 cites W3129785550 @default.
- W4309751465 cites W3158467383 @default.
- W4309751465 cites W3213054069 @default.
- W4309751465 cites W4200250643 @default.
- W4309751465 doi "https://doi.org/10.21203/rs.3.rs-2280909/v1" @default.
- W4309751465 hasPublicationYear "2022" @default.
- W4309751465 type Work @default.
- W4309751465 citedByCount "0" @default.
- W4309751465 crossrefType "posted-content" @default.
- W4309751465 hasAuthorship W4309751465A5000154613 @default.
- W4309751465 hasAuthorship W4309751465A5017951067 @default.
- W4309751465 hasAuthorship W4309751465A5021557384 @default.
- W4309751465 hasAuthorship W4309751465A5049132248 @default.
- W4309751465 hasAuthorship W4309751465A5049236401 @default.
- W4309751465 hasAuthorship W4309751465A5055838125 @default.
- W4309751465 hasAuthorship W4309751465A5065973605 @default.
- W4309751465 hasAuthorship W4309751465A5074221408 @default.
- W4309751465 hasAuthorship W4309751465A5077322975 @default.
- W4309751465 hasAuthorship W4309751465A5077885898 @default.
- W4309751465 hasAuthorship W4309751465A5079647691 @default.
- W4309751465 hasAuthorship W4309751465A5084619384 @default.
- W4309751465 hasBestOaLocation W43097514651 @default.
- W4309751465 hasConcept C11960822 @default.
- W4309751465 hasConcept C136449434 @default.
- W4309751465 hasConcept C14036430 @default.
- W4309751465 hasConcept C170493617 @default.
- W4309751465 hasConcept C203014093 @default.
- W4309751465 hasConcept C2776914184 @default.
- W4309751465 hasConcept C49039625 @default.
- W4309751465 hasConcept C54166955 @default.
- W4309751465 hasConcept C55493867 @default.
- W4309751465 hasConcept C62478195 @default.
- W4309751465 hasConcept C86803240 @default.
- W4309751465 hasConcept C8891405 @default.
- W4309751465 hasConcept C95444343 @default.
- W4309751465 hasConceptScore W4309751465C11960822 @default.
- W4309751465 hasConceptScore W4309751465C136449434 @default.
- W4309751465 hasConceptScore W4309751465C14036430 @default.
- W4309751465 hasConceptScore W4309751465C170493617 @default.
- W4309751465 hasConceptScore W4309751465C203014093 @default.
- W4309751465 hasConceptScore W4309751465C2776914184 @default.
- W4309751465 hasConceptScore W4309751465C49039625 @default.
- W4309751465 hasConceptScore W4309751465C54166955 @default.
- W4309751465 hasConceptScore W4309751465C55493867 @default.
- W4309751465 hasConceptScore W4309751465C62478195 @default.
- W4309751465 hasConceptScore W4309751465C86803240 @default.
- W4309751465 hasConceptScore W4309751465C8891405 @default.