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- W4309754106 abstract "Abstract Spatial embryo profiling (STEP) combines laser capture microdissection (LCM)-assisted sample collection for Smart-Seq2 profiling with virtual reconstruction of stereological immunofluorescence images of implanted primate embryos. Frozen, unfixed embryos O.C.T.-embedded in utero are cryosectioned, with every second to third embryo-containing section subjected to LCM for collection of tissue samples of one-to-three cells and processed individually for full-length transcriptome profiling. Remaining sections are fixed and processed for immunofluorescence staining, followed by stereological confocal microscopy, image registration, tissue segmentation and surface generation to create virtual 3D embryo models. Gaussian process regression following the integration of discrete, spatially defined transcriptome samples allows modelling of 3D gene expression patterns across the entire embryo model." @default.
- W4309754106 created "2022-11-29" @default.
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- W4309754106 date "2022-11-21" @default.
- W4309754106 modified "2023-10-17" @default.
- W4309754106 title "Spatial embryo profiling (STEP) of primate implantation stages" @default.
- W4309754106 doi "https://doi.org/10.21203/rs.3.pex-1899/v1" @default.
- W4309754106 hasPublicationYear "2022" @default.
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