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- W4309762010 abstract "Brain metastasis occurs in approximately 30% of patients with lung adenocarcinoma (LUAD) and is closely associated with poor prognosis, recurrence, and death. However, dynamic gene regulation and molecular mechanism driving LUAD progression remain poorly understood. In this study, we performed a comprehensive single-cell transcriptome analysis using data from normal, early stage, advanced stage, and brain metastasis LUAD. Our single-cell-level analysis reveals the cellular composition heterogeneity at different stages during LUAD progression. We identified stage-specific risk genes that could contribute to LUAD progression and metastasis by reprogramming immune-related and metabolic-related functions. We constructed an early advanced metastatic dysregulated network and revealed the dynamic changes in gene regulations during LUAD progression. We identified 6 early advanced (HLA-DRB1, HLA-DQB1, SFTPB, SFTPC, PLA2G1B, and FOLR1), 8 advanced metastasis (RPS15, RPS11, RPL13A, RPS24, HLA-DRB5, LYPLA1, KCNJ15, and PSMA3), and 2 common risk genes in different stages (SFTPD and HLA-DRA) as prognostic markers in LUAD. Particularly, decreased expression of HLA-DRA, HLA-DRB1, HLA-DQB1, and HLA-DRB5 refer poor prognosis in LUAD by controlling antigen processing and presentation and T cell activation. Increased expression of PSMA3 and LYPLA1 refer poor prognosis by reprogramming fatty acid metabolism and RNA catabolic process. Our findings will help further understanding the pathobiology of brain metastases in LUAD." @default.
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- W4309762010 date "2022-12-01" @default.
- W4309762010 modified "2023-09-30" @default.
- W4309762010 title "The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis" @default.
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- W4309762010 cites W2035618305 @default.
- W4309762010 cites W2084388859 @default.
- W4309762010 cites W2105985721 @default.
- W4309762010 cites W2109621565 @default.
- W4309762010 cites W2129899548 @default.
- W4309762010 cites W2129992678 @default.
- W4309762010 cites W2137790111 @default.
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- W4309762010 cites W2140258573 @default.
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- W4309762010 cites W2159675211 @default.
- W4309762010 cites W2172195425 @default.
- W4309762010 cites W2335037156 @default.
- W4309762010 cites W2423277228 @default.
- W4309762010 cites W2537623931 @default.
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- W4309762010 cites W2794480084 @default.
- W4309762010 cites W2884310345 @default.
- W4309762010 cites W2886347923 @default.
- W4309762010 cites W2894216826 @default.
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- W4309762010 cites W3027384030 @default.
- W4309762010 cites W3033625547 @default.
- W4309762010 cites W305698754 @default.
- W4309762010 cites W3088774677 @default.
- W4309762010 cites W3096053481 @default.
- W4309762010 cites W3100072141 @default.
- W4309762010 cites W3108354267 @default.
- W4309762010 cites W3114797916 @default.
- W4309762010 cites W3132807981 @default.
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- W4309762010 doi "https://doi.org/10.1016/j.omtn.2022.11.019" @default.
- W4309762010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36514354" @default.
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