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- W4309762013 abstract "Summary Certain serum proteins, including CRP and D-dimer, have prognostic value in patients with SARS-CoV-2 infection. Nonetheless, these factors are non-specific, and provide limited mechanistic insight into the peripheral blood mononuclear cell (PBMC) populations which drive the pathogenesis of severe COVID-19. To identify novel cellular phenotypes associated with disease progression, we here describe a comprehensive, unbiased analysis of the total and plasma membrane proteomes of PBMCs from a cohort of 40 unvaccinated individuals with SARS-CoV-2 infection, spanning the whole spectrum of disease severity. Combined with RNA-seq and flow cytometry data from the same donors, we define a comprehensive multi-omic profile for each severity level, revealing cumulative immune cell dysregulation in progressive disease. In particular, the cell surface proteins CEACAMs1, 6 and 8, CD177, CD63 and CD89 are strongly associated with severe COVID-19, corresponding to the emergence of atypical CD3 + CD4 + CD177 + and CD16 + CEACAM1/6/8 + mononuclear cells. Utilisation of these markers may facilitate real-time patient assessment by flow cytometry, and identify immune cell populations that could be targeted to ameliorate immunopathology." @default.
- W4309762013 created "2022-11-29" @default.
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- W4309762013 date "2022-11-18" @default.
- W4309762013 modified "2023-10-07" @default.
- W4309762013 title "Proteomic analysis of circulating immune cells identifies novel cellular phenotypes associated with COVID-19 severity" @default.
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- W4309762013 doi "https://doi.org/10.1101/2022.11.16.22282338" @default.
- W4309762013 hasPublicationYear "2022" @default.
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