FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309762531> ?p ?o ?g. }

• W4309762531 endingPage "100375" @default.
• W4309762531 startingPage "100375" @default.
• W4309762531 abstract "Anxiety is one of the psychiatric disorders that disturbs routine life including moods and motivation. Excessive anxiety causes mental illnesses or anxiety disorders, which are commonly treated by synthetic medicines. Recently, there is a substantial increase in the studies of phytochemicals as alternatives to first-line conventional anxiolytic drugs. Yet there is insufficient information about the mechanisms of how these bioactive constitutes from plants manage anxiety disorders. This systematic review aims to answer the following research questions: 1) Which plant extracts and phytochemicals have anxiolytic effect? what is the mechanism of action? 2) Have human trials been conducted to confirm their anxiolytic effect? 3) If not, which plants/phytochemicals are recommended for further human trials? To define and summarize such information, this systematic review consolidated in vitro, preclinical, and clinical studies that examine the anti-anxiety activity of plant extracts via oral administration, conducted through three scientific databases including PubMed, Scopus, and Google Scholar following the PRISMA protocol. Similar to synthetic drugs, most bioactive phytochemical compounds modulate anxiolytic activity through six main neurotransmitter pathways including acetylcholine (ACh), γ-aminobutyric acid (GABA), glutamate, serotonin (5-HT), dopamine (DA), and norepinephrine (NE). These bioactive compounds mainly belong to phenolics, alkaloids, and terpenoids, and they demonstrated effective therapeutic benefits against anxiety symptoms. Four plants, including Aloysia polystachya, Lavandula angustifolia, Matricaria chamomilla L. and Humulus lupulus, have been evaluated in human trials. However, studies on majority plants were performed using animal models, and among them, Tanacetum parthenium L. Schultz-Bip (Asreraceae), demethoxysudachitin, Albizzia julibrissin, Nelumbo nucifera Gaertn. leaves, Zizyphi spinosi semen seed extract, obovatol, Mangifera indica stem barks, Nectandra grandiflora Ness and Lavandula angustifolia, Bupleurum yinchowense roots, Citrus aurantium L. and Foeniculum vulgare exhibited the most significant anxiolytic effect at dosage of 30 mg/kg/day or lower. Further human trials are recommended to validate the efficacy and safety of these plants/plant extracts/phytochemicals in managing psychiatric disorders." @default.
• W4309762531 created "2022-11-29" @default.
• W4309762531 creator A5000439234 @default.
• W4309762531 creator A5018390432 @default.
• W4309762531 creator A5035857696 @default.
• W4309762531 creator A5079876716 @default.
• W4309762531 creator A5082824330 @default.
• W4309762531 date "2022-11-01" @default.
• W4309762531 modified "2023-10-16" @default.
• W4309762531 title "Plants and phytochemicals potentials in tackling anxiety: A systematic review" @default.
• W4309762531 cites W1519746197 @default.
• W4309762531 cites W1662638861 @default.
• W4309762531 cites W1855716997 @default.
• W4309762531 cites W1879721258 @default.
• W4309762531 cites W1963601419 @default.
• W4309762531 cites W1968572762 @default.
• W4309762531 cites W1970277162 @default.
• W4309762531 cites W1970956725 @default.
• W4309762531 cites W1974145637 @default.
• W4309762531 cites W1977000940 @default.
• W4309762531 cites W1980032765 @default.
• W4309762531 cites W1983668791 @default.
• W4309762531 cites W1985871295 @default.
• W4309762531 cites W1989531578 @default.
• W4309762531 cites W1989578288 @default.
• W4309762531 cites W1989870541 @default.
• W4309762531 cites W1990429945 @default.
• W4309762531 cites W1991155688 @default.
• W4309762531 cites W1994136305 @default.
• W4309762531 cites W1999471342 @default.
• W4309762531 cites W2006065882 @default.
• W4309762531 cites W2008143143 @default.
• W4309762531 cites W2008929007 @default.
• W4309762531 cites W2010391271 @default.
• W4309762531 cites W2011041824 @default.
• W4309762531 cites W2012575249 @default.
• W4309762531 cites W2016526231 @default.
• W4309762531 cites W2019768085 @default.
• W4309762531 cites W2023253074 @default.
• W4309762531 cites W2025858585 @default.
• W4309762531 cites W2026569432 @default.
• W4309762531 cites W2026605955 @default.
• W4309762531 cites W2028835636 @default.
• W4309762531 cites W2032610103 @default.
• W4309762531 cites W2038355081 @default.
• W4309762531 cites W2040837188 @default.
• W4309762531 cites W2043904891 @default.
• W4309762531 cites W2044061877 @default.
• W4309762531 cites W2044255919 @default.
• W4309762531 cites W2046259073 @default.
• W4309762531 cites W2049302266 @default.
• W4309762531 cites W2050995627 @default.
• W4309762531 cites W2052111346 @default.
• W4309762531 cites W2053368505 @default.
• W4309762531 cites W2053583475 @default.
• W4309762531 cites W2053642263 @default.
• W4309762531 cites W2058116214 @default.
• W4309762531 cites W2059848053 @default.
• W4309762531 cites W2060855069 @default.
• W4309762531 cites W2064438779 @default.
• W4309762531 cites W2070290419 @default.
• W4309762531 cites W2078974273 @default.
• W4309762531 cites W2080674400 @default.
• W4309762531 cites W2091881469 @default.
• W4309762531 cites W2105031628 @default.
• W4309762531 cites W2105916826 @default.
• W4309762531 cites W2111604034 @default.
• W4309762531 cites W2112121431 @default.
• W4309762531 cites W2117036846 @default.
• W4309762531 cites W2126143811 @default.
• W4309762531 cites W2134565601 @default.
• W4309762531 cites W2147289447 @default.
• W4309762531 cites W2163413605 @default.
• W4309762531 cites W2168367599 @default.
• W4309762531 cites W2177596836 @default.
• W4309762531 cites W2257619691 @default.
• W4309762531 cites W2281355237 @default.
• W4309762531 cites W2297698540 @default.
• W4309762531 cites W2320804095 @default.
• W4309762531 cites W2327535145 @default.
• W4309762531 cites W2340236550 @default.
• W4309762531 cites W2409668979 @default.
• W4309762531 cites W2410167174 @default.
• W4309762531 cites W2417192837 @default.
• W4309762531 cites W2468299890 @default.
• W4309762531 cites W2536500264 @default.
• W4309762531 cites W2536739553 @default.
• W4309762531 cites W2587034260 @default.
• W4309762531 cites W2588357968 @default.
• W4309762531 cites W2763910528 @default.
• W4309762531 cites W2770399954 @default.
• W4309762531 cites W2771915844 @default.
• W4309762531 cites W2772336755 @default.
• W4309762531 cites W2775266718 @default.
• W4309762531 cites W2791683483 @default.
• W4309762531 cites W2794175039 @default.
• W4309762531 cites W2795555410 @default.
• W4309762531 cites W2804552154 @default.

• next